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A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma: a retrospective, prospective and multicenter study
BackgroundCurrently, there is no clinically relevant non-invasive biomarker for early detection of esophageal squamous cell carcinoma (ESCC). Herein,...
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Rational and design of prophylactic cranial irradiation (PCI) and brain MRI surveillance versus brain MRI surveillance alone in patients with limited-stage small cell lung cancer achieving complete remission (CR) of tumor after chemoradiotherapy: a multicenter prospective randomized study
BackgroundProphylactic cranial irradiation (PCI) is part of standard care in limited-stage small cell lung cancer (SCLC) at present. As evidence from...
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The Prospective Lynch Syndrome Database: background, design, main results and complete MySQL code
A brief description of why and for which purposes the Prospective Lynch Syndrome Database was established, the principles and design, and the main...
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Real-world economic evaluation of prospective rapid whole-genome sequencing compared to a matched retrospective cohort of critically ill pediatric patients in the United States
There is an increasing demand for supporting the adoption of rapid whole-genome sequencing (rWGS) by demonstrating its real-world value. We aimed to...
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From retrospective to prospective memory research: a framework for investigating the deactivation of intentions
The definition of episodic memory has evolved into a multifaceted concept that gathered great attention in several research areas in psychology and...
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Optimal sample selection applied to information rich, dense data
Dense data can be classified into superdense information-poor data (type 1 dense data) and dense information-rich data (type 2 dense data)....
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Global entrainment in the brain–body–environment: retrospective and prospective views
We celebrate the 60th anniversary of Biological Cybernetics . It has also been 30 years since “Self-organized control of bipedal locomotion by neural...
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Two decades of capacity building to support global malaria control and elimination: retrospective and prospective international trainings in Jiangsu Institute of Parasitic Diseases, China, 2002–2021
BackgroundMalaria is still one of the major infectious diseases affecting human health, and the World Health Organization (WHO) has attached special...
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Evaluation of CTRL: a web application for dynamic consent and engagement with individuals involved in a cardiovascular genetic disorders cohort
There has been keen interest in whether dynamic consent should be used in health research but few real-world studies have evaluated its use....
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Clinical trial design in the era of precision medicine
Recent rapid biotechnological breakthroughs have led to the identification of complex and unique molecular features that drive malignancies....
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Serum matrix metalloproteinase-7 for discriminating biliary atresia: a diagnostic accuracy and validation study
BackgroundPrompt and precise differential diagnosis of biliary atresia (BA) among cholestatic patients is of great importance. Matrix...
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Endovascular Thrombectomy for Acute Basilar Artery Occlusion: Latest Findings and Critical Thinking on Future Study Design
Randomized controlled trials (RCTs) have demonstrated powerful efficacy of endovascular thrombectomy (EVT) for large vessel occlusion in the anterior...
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Intravenous immunoglobulin for treatment of hospitalized COVID-19 patients: an evidence map** and meta-analysis
BackgroundThe clinical efficacy and safety of intravenous immunoglobulin (IVIg) treatment for COVID-19 remain controversial. This study aimed to map...
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Toxicity When Combining Immunotherapy and Radiotherapy
Background: Radiation toxicity in monotherapy has been widely studied, together with its possible combinations with...
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Rare subtypes of triple negative breast cancer: Current understanding and future directions
Rare subtypes of triple-negative breast cancers (TNBC) are a heterogenous group of tumors, comprising 5–10% of all TNBCs. Despite accounting for an...
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Efficacy of adding levofloxacin to gemcitabine and nanoparticle-albumin-binding paclitaxel combination therapy in patients with advanced pancreatic cancer: study protocol for a multicenter, randomized phase 2 trial (T-CORE2201)
BackgroundAdvanced pancreatic cancer is one of the leading causes of cancer-related deaths. For patients with advanced pancreatic cancer, gemcitabine...
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Real-World Evidence: A Primer
Real-world evidence (RWE) is clinical evidence on a medical product’s safety and efficacy that is generated using real-world data (RWD) resulting...
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Prospective analysis of sleep characteristics, chronotype, and risk of breast cancer in the california teachers study
PurposePoor sleep quality and evening chronotype were associated with increased risk of breast cancer in a previous retrospective study in the...
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Prospective phase II trial of preoperative hypofractionated proton therapy for extremity and truncal soft tissue sarcoma: the PRONTO study rationale and design
BackgroundOncologic surgical resection is the standard of care for extremity and truncal soft tissue sarcoma (STS), often accompanied by the addition...
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Genomic classifiers and prognosis of localized prostate cancer: a systematic review
BackgroundRefinement of the risk classification for localized prostate cancer is warranted to aid in clinical decision making. A systematic analysis...
