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Loss of MBNL1-mediated retrograde BDNF signaling in the myotonic dystrophy brain
Reduced brain volume including atrophy in grey and white matter is commonly seen in myotonic dystrophy type 1 (DM1). DM1 is caused by an expansion of...
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Mitochondrially mediated RNA interference, a retrograde signaling system affecting nuclear gene expression
Several functional classes of short noncoding RNAs are involved in manifold regulatory processes in eukaryotes, including, among the best...
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Analysis of Mitochondrial Retrograde Signaling in Yeast Model Systems
Mitochondrial retrograde signaling is a mitochondria-to-nucleus communication pathway, conserved from yeast to humans, by which dysfunctional...
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Retrograde Signaling Via Dendritic Activation of Glial-Neuronal Circuits
Neuroendocrine cells in the hypothalamus secrete neuropeptides from both their axon terminals and their dendrites to regulate homeostatic function....
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A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys
Retrograde adeno-associated viruses (AAVs) are capable of infecting the axons of projection neurons and serve as a powerful tool for the anatomical...
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HiRet/NeuRet Vectors: Lentiviral System for Highly Efficient Gene Transfer Through Retrograde Axonal Transport
Lentiviral vectors are used for a wide range of research applications in the field of neuroscience. Notably, lentiviral tropism can be manipulated by...
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Analysis of the spinal and vagal afferent innervation of the mouse colon using neuronal retrograde tracers
The gut-brain axis has received increasing attention recently due to evidence that colonic microbes can affect brain function and behavior. However,...
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GDNF synthesis, signaling, and retrograde transport in motor neurons
Glial cell line–derived neurotrophic factor (GDNF) is a 134 amino acid protein belonging in the GDNF family ligands (GFLs). GDNF was originally...
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Postsynaptic synucleins mediate endocannabinoid signaling
Endocannabinoids are among the most powerful modulators of synaptic transmission throughout the nervous system, and yet little is understood about...
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Joubert syndrome causing mutation in C2 domain of CC2D2A affects structural integrity of cilia and cellular signaling molecules
Cilia are organelles extend from cells to sense external signals for tuning intracellular signaling for optimal cellular functioning. They have...
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Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axons
RET (REarranged during Transfection) is a receptor tyrosine kinase that transduces various external stimuli into biological functions, such as...
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HIF-1 signaling: an emerging mechanism for mitochondrial dynamics
A growing emphasis has been paid to the function of mitochondria in tumors, neurodegenerative disorders (NDs), and cardiovascular diseases....
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NGF Signaling in Endosomes
During the development of the nervous system, neurons respond to diffusible cues secreted by target cells. Because such target-derived factors...
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TNFα-Induced Altered miRNA Expression Links to NF-κB Signaling Pathway in Endometriosis
Endometriosis is a common gynecological inflammatory disorder characterized by immune system dysregulation, which is involved in lesion initiation...
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Increased sympathetic outflow induced by emotional stress aggravates myocardial ischemia–reperfusion injury via activation of TLR7/MyD88/IRF5 signaling pathway
Background and objectiveEmotional stress substantially increases the risk of ischemic cardiovascular diseases. Previous study indicates that...
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SWI/SNF Complex Connects Signaling and Epigenetic State in Cells of Nervous System
SWI/SNF protein complexes are evolutionarily conserved epigenetic regulators described in all eukaryotes. In metameric animals, the complexes are...
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Combining network pharmacology and experimental verification to reveal the mechanism of Chaigui granules in the treatment of depression through PI3K/Akt/mTOR signaling pathways
IntroductionChaigui granules are a novel manufactured traditional Chinese antidepressant medicine, which is originated from the ancient classical...
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Gastrodin Ameliorates Post-Stroke Depressive-Like Behaviors Through Cannabinoid-1 Receptor-Dependent PKA/RhoA Signaling Pathway
Post-stroke depression (PSD) is a significant complication in stroke patients, increases long-term mortality, and exaggerates ischemia-induced brain...
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The RNA sequencing results revealed the expression of different genes and signaling pathways during chemotherapy resistance in peripheral T-cell lymphoma
BackgroundPeripheral T-cell lymphoma (PTCL) is a subtype of non-Hodgkin's lymphoma that occurs primarily at extranodal sites and is commonly treated...
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M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast–Schwann cell-signaling relay
BackgroundAlthough peripheral nerves have an intrinsic self-repair capacity following damage, functional recovery is limited in patients. It is a...
