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A novel biomarker associated with EBV infection improves response prediction of immunotherapy in gastric cancer
BackgroundNovel biomarkers are required in gastric cancer (GC) treated by immunotherapy. Epstein-Barr virus (EBV) infection induces an immune-active...
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Soluble Periostin is a potential surveillance biomarker for early and long-term response to chemotherapy in advanced breast cancer
BackgroundNoninvasive biomarkers for the assessment of response to chemotherapy in advanced breast cancer (BCa) are essential for optimized...
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RNA-binding proteins signature is a favorable biomarker of prognosis, immunotherapy and chemotherapy response for cervical cancer
Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) still present a huge threaten to women’s health, especially the local...
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Mutational variant allele frequency profile as a biomarker of response to immune checkpoint blockade in non-small cell lung Cancer
IntroductionIdentifying new biomarkers for predicting immune checkpoint inhibitors (ICIs) response in non-small cell lung cancer (NSCLC) is crucial....
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Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response
BackgroundThe inability to predict treatment response of colorectal cancer patients results in unnecessary toxicity, decreased efficacy and survival....
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Evaluation of cross-platform compatibility of a DNA methylation-based glucocorticoid response biomarker
BackgroundIdentifying blood-based DNA methylation patterns is a minimally invasive way to detect biomarkers in predicting age, characteristics of...
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Fortilin as a Biomarker in Toxicity
Fortilin, the multifunctional protein, also known as translationally controlled tumor protein (TCTP), presents in most eukaryotic organisms. It is...
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Serum miRNA-1 may serve as a promising noninvasive biomarker for predicting treatment response in breast cancer patients receiving neoadjuvant chemotherapy
BackgroundMicroRNA-1 (miR-1) is a tumour suppressor that can inhibit cell proliferation and invasion in several cancer types. In addition, miR-1 was...
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Pan-cancer analysis of TASL: a novel immune infiltration-related biomarker for tumor prognosis and immunotherapy response prediction
BackgroundNew immunotherapeutic strategies based on predictors are urgently needed. Toll-like receptor adaptor interacting with SLC15A4 on the...
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CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response
BackgroundThe Alzheimer’s disease (AD) risk gene ABCA7 has suggested functions in lipid metabolism and the immune system. Rare premature termination...
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Detection of circulating cell-free HPV DNA of 13 HPV types for patients with cervical cancer as potential biomarker to monitor therapy response and to detect relapse
BackgroundHPV-related cervical cancer (CC) is the fourth most frequent cancer in women worldwide. Cell-free tumour DNA is a potent biomarker to...
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Proteomics in Huntington’s Disease Biomarker Discovery
Mass spectrometry (MS) and proteomics are continuously evolving methods in systems biology that carry enormous potential for accurately profiling the...
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Comprehensive analysis and validation of SNX7 as a novel biomarker for the diagnosis, prognosis, and prediction of chemotherapy and immunotherapy response in hepatocellular carcinoma
BackgroundStudies have demonstrated that Sorting nexin 7 (SNX7) functions as an anti-apoptotic protein in liver tissue and plays a crucial role in...
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Adult Stem Cells as a Biomarker in Diabetes
Obesity, diabetes, and cardiovascular diseases (CVD) are increasing rapidly worldwide. It is important to know the effect of exercise, medications...
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Serum Interleukin-6 Levels as a Biomarker in Trauma
The degree of injury that occurs after trauma is proportional to the exposure of trauma energy exceeding the threshold of physiological tolerance of...
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PCDH11X mutation as a potential biomarker for immune checkpoint therapies in lung adenocarcinoma
AbstractImmune checkpoint inhibitors (ICIs) have achieved impressive success in lung adenocarcinoma (LUAD). However, the response to ICIs varies...
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Is Methylglyoxal a Potential Biomarker for the Warburg Effect Induced by the Lipopolysaccharide Neuroinflammation Model?
Methylglyoxal (MG) is considered a classical biomarker of diabetes mellitus and its comorbidities. However, a role for this compound in exacerbated...
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Erythrocyte Acetylcholinesterase as a Biomarker of Environmental Lead Exposure
Lead is a prime, ubiquitous, environmental toxicant and multi-organ poison. One of the most recognized deleterious effects of lead exposure is...
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Cancer testis antigen burden (CTAB): a novel biomarker of tumor-associated antigens in lung cancer
BackgroundCancer-testis antigens (CTAs) are tumor antigens that are normally expressed in the testes but are aberrantly expressed in several cancers....
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S100A6: molecular function and biomarker role
S100A6 (also called calcyclin) is a Ca 2+ -binding protein that belongs to the S100 protein family. S100A6 has many functions related to the...
