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Fetal hemoglobin induction in azacytidine responders enlightens methylation patterns related to blast clearance in higher-risk MDS and CMML
BackgroundAs new treatment options for patients with higher-risk myelodysplastic syndromes are emerging, identification of prognostic markers for...
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High burden of clonal hematopoiesis in first responders exposed to the World Trade Center disaster
The terrorist attacks on the World Trade Center (WTC) created an unprecedented environmental exposure to aerosolized dust, gases and potential...
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Machine learning-based multiparametric MRI radiomics for predicting poor responders after neoadjuvant chemoradiotherapy in rectal Cancer patients
BackgroundThe purpose of this study was to investigate and validate multiparametric magnetic resonance imaging (MRI)-based machine learning...
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Dissecting immune cell stat regulation network reveals biomarkers to predict ICB therapy responders in melanoma
BackgroundImmunotherapy is a revolutionary strategy in cancer therapy, but the resistance of which is one of the important challenges. Detecting the...
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Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders
Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and viral infections. They are ‘first responders’ that can...
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No evidence of disease versus residual disease in long-term responders to first-line HER2-targeted therapy for metastatic breast cancer
BackgroundLong-term response to HER2-targeted therapies is infrequent in metastatic breast cancer (MBC). We evaluated clinical characteristics of...
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Characteristics of exceptional responders to autologous stem cell transplantation in multiple myeloma
Autologous stem cell transplantation (ASCT) is an important treatment modality in multiple myeloma (MM). However, relapse following ASCT is...
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Feasibility of combining functional near-infrared spectroscopy with electroencephalography to identify chronic stroke responders to cerebellar transcranial direct current stimulation—a computational modeling and portable neuroimaging methodological study
Feasibility of portable neuroimaging of cerebellar transcranial direct current stimulation (ctDCS) effects on the cerebral cortex has not been...
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Whole-exome sequencing of long-term, never relapse exceptional responders of trastuzumab-treated HER2+ metastatic breast cancer
Trastuzumab has significantly improved the overall survival of patients with HER2+ metastatic breast cancer (MBC). However, outcomes can vary, with...
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Circulating miR-21 as a prognostic biomarker in HCC treated by CT-guided high-dose rate brachytherapy
Background and aimsPrognostic biomarkers identifying patients with early tumor progression after local ablative therapy remain an unmet clinical...
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Prediction of treatment response in major depressive disorder using a hybrid of convolutional recurrent deep neural networks and effective connectivity based on EEG signal
In this study, we have developed a novel method based on deep learning and brain effective connectivity to classify responders and non-responders to...
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Outcomes of sentinel node biopsy according to MRI response in an association with the subtypes in cN1–3 breast cancer after neoadjuvant systemic therapy, multicenter cohort study
BackgroundThis study investigated the feasibility of sentinel lymph node biopsy (SLNB) after neoadjuvant systemic therapy (NAST) in patients with...
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Single-cell genomics of uncultured bacteria reveals dietary fiber responders in the mouse gut microbiota
Abstract BackgroundThe gut microbiota can have dramatic effects on host metabolism; however, current genomic strategies for uncultured bacteria have...
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The role of computed tomography features in assessing response to neoadjuvant chemotherapy in locally advanced gastric cancer
ObjectiveTo compare the computed tomography (CT) images of patients with locally advanced gastric cancer (GC) before and after neoadjuvant...
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Long-Term Effect of Switching From an Anti-CGRP Receptor to an Anti-CGRP Ligand Antibody in Treatment-Refractory Chronic Migraine: A Prospective Real-World Analysis
In migraine patients with a poor response to a calcitonin gene-related peptide monoclonal antibody against the receptor, switching to a calcitonin...
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Notch ligands are biomarkers of anti-TNF response in RA patients
Notch and its ligands play a critical role in rheumatoid arthritis (RA) pathogenesis. Hence, studies were conducted to delineate the functional...
