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Latent neural population dynamics underlying breathing, opioid-induced respiratory depression and gas**
Breathing is vital and must be concurrently robust and flexible. This rhythmic behavior is generated and maintained within a rostrocaudally aligned...
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Mechanisms of opioid-induced respiratory depression
Opioid-induced respiratory depression (OIRD), the primary cause of opioid-induced death, is the neural depression of respiratory drive which,...
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Neonatal opioid toxicity: opioid withdrawal (abstinence) syndrome with emphasis on pharmacogenomics and respiratory depression
The increasing use of opioids in pregnant women has led to an alarming rise in the number of cases of neonates with drug-induced withdrawal symptoms...
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Toxicities of opioid analgesics: respiratory depression, histamine release, hemodynamic changes, hypersensitivity, serotonin toxicity
Opioid-induced respiratory depression is potentially life-threatening and often regarded as the main hazard of opioid use. Main cause of death is...
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Strong opioids-induced cardiac, neurologic, and respiratory disorders: a real-world study from 2004 to 2023 based on FAERS
Opioids are mainly used as adjuncts to the induction and maintenance of general anesthesia, postoperative analgesia, and treating moderate to severe...
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Respiratory effects of oral mitragynine and oxycodone in a rodent model
RationaleKratom derives from Mitragyna speciosa (Korth.), a tropical tree in the genus Mitragyna (Rubiaceae) that also includes the coffee tree....
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Application of a Biofeedback Method in the Treatment of Depression
With the aim of systematizing scientific data in the current Russian and foreign literature on the efficacy of biofeedback (BF) in the treatment of...
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Acute sodium bicarbonate administration improves ventilatory efficiency in experimental respiratory acidosis: clinical implications
Administering sodium bicarbonate (NaHCO 3 ) to patients with respiratory acidosis breathing spontaneously is contraindicated because it increases...
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Sodium Leak Channel in Glutamatergic Neurons of the Lateral Parabrachial Nucleus Helps to Maintain Respiratory Frequency Under Sevoflurane Anesthesia
The lateral parabrachial nucleus (PBL) is implicated in the regulation of respiratory activity. Sodium leak channel (NALCN) mutations disrupt the...
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Severe Acute Respiratory Syndrome Coronaviruses-2 (SARS-CoV-2)
The emergence of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was initially described in late 2019 in Wuhan City, China, and was... -
Severe Acute Respiratory Syndrome Coronaviruses-2 (SARS-CoV-2)
The emergence of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was initially described in late 2019 in Wuhan City, China, and was... -
Anxiety and Depression During the COVID-19 Pandemic and Their Impact on Sleep
The effects of COVID-19 on mental health are severe. It is widely acknowledged that there is a link between anxiety, depression, and sleep disorders.... -
Therapeutic potential and possible mechanisms of ginseng for depression associated with COVID-19
Recently, a global outbreak of COVID-19 has rapidly spread to various national regions. As the number of COVID-19 patients has increased, some of...
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Early-life respiratory infections and developmental immunity determine lifelong lung health
Respiratory infections are common in infants and young children. However, the immune system develops and matures as the child grows, thus the effects...
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An implantable soft robotic ventilator augments inspiration in a pig model of respiratory insufficiency
Severe diaphragm dysfunction can lead to respiratory failure and to the need for permanent mechanical ventilation. Yet permanent tethering to a...
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Respiratory Disorders: Contemporary Issues in 2020
Respiratory system bears the major brunt of environmental insults. Respiratory infections such as pneumonias continue to threaten human health. The... -
Effects of aconitine on the respiratory activity of brainstem-spinal cord preparations isolated from newborn rats
Aconitine is a sodium channel opener, but its effects on the respiratory center are not well understood. We investigated the dose-dependent effects...
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Peritoneal sepsis caused by Escherichia coli triggers brainstem inflammation and alters the function of sympatho-respiratory control circuits
BackgroundSepsis has a high mortality rate due to multiple organ failure. However, the influence of peripheral inflammation on brainstem autonomic...
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Effects of Exercise Interventions on Anxiety and Depression in Patients with Lung Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trails
ObjectiveThe purpose of this meta-analysis was to estimate the effect of exercise interventions on anxiety and depression in patients with lung...
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Epidemiology and clinical severity of the serotypes of human parainfluenza virus in children with acute respiratory infection
BackgroundAcute respiratory infections (ARI) are a threat to human health and survival, resulting in many paediatric hospitalisations. However, the...