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A Potential Role for Neuroinflammation in ADHD
Attention deficit hyperactivity disorder (ADHD) is a neurobehavioural disorder in children and adolescents. Although increases in oxidative stress...
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Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach
The recent progress in the development of in vivo biomarkers is rapidly changing how neurodegenerative diseases are conceptualized and diagnosed and...
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Characterizing neuroinflammation and identifying prenatal diagnostic markers for neural tube defects through integrated multi-omics analysis
BackgroundNeural Tube Defects (NTDs) are congenital malformations of the central nervous system resulting from the incomplete closure of the neural...
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Neuroinflammation increases oxygen extraction in a mouse model of Alzheimer’s disease
BackgroundNeuroinflammation, impaired metabolism, and hypoperfusion are fundamental pathological hallmarks of early Alzheimer’s disease (AD)....
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Post-traumatic Stress Disorder: Focus on Neuroinflammation
Post-traumatic stress disorder (PTSD), gaining increasing attention, is a multifaceted psychiatric disorder that occurs following a stressful or...
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Emerging role of non-coding RNAs in neuroinflammation mediated by microglia and astrocytes
Neuroinflammation has been implicated in the initiation and progression of several central nervous system (CNS) disorders, including Alzheimer’s...
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Microbiota-derived acetate attenuates neuroinflammation in rostral ventrolateral medulla of spontaneously hypertensive rats
BackgroundIncreased neuroinflammation in brain regions regulating sympathetic nerves is associated with hypertension. Emerging evidence from both...
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Using Small Molecules for Targeting Heavy Metals in Neurotoxicity and Neuroinflammation
Pharmaceutical drugs, natural toxins, industrial chemicals, and various environmental toxins negatively impact the nervous system. A significant...
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mTOR and neuroinflammation in epilepsy: implications for disease progression and treatment
Epilepsy remains a major health concern as anti-seizure medications frequently fail, and there is currently no treatment to stop or prevent...
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Gypenoside Pretreatment Alleviates the Cerebral Ischemia Injury via Inhibiting the Microglia-Mediated Neuroinflammation
Neuroinflammation is closely related to prognosis in ischemic stroke. Microglia are the main immune cells in the nervous system. Under physiological...
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Increased cysteinyl-tRNA synthetase drives neuroinflammation in Alzheimer’s disease
BackgroundMicroglia-mediated neuroinflammation in Alzheimer’s disease (AD) is not only a response to pathophysiological events, but also plays a...
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Mer activation ameliorates nerve injury-induced neuropathic pain by regulating microglial polarization and neuroinflammation via SOCS3 in male rats
Accumulating evidence has demonstrated that M1 microglial polarization and neuroinflammation worsen the development of neuropathic pain. However, the...
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Lipoxins A4 and B4 inhibit glial cell activation via CXCR3 signaling in acute retinal neuroinflammation
Lipoxins are small lipids that are potent endogenous mediators of systemic inflammation resolution in a variety of diseases. We previously reported...
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Doxycycline-Loaded Calcium Phosphate Nanoparticles with a Pectin Coat Can Ameliorate Lipopolysaccharide-Induced Neuroinflammation Via Enhancing AMPK
Neuroinflammation occurs in response to different injurious triggers to limit their hazardous effects. However, failure to stop this process can end...
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Chronic neuroinflammation during aging leads to cholinergic neurodegeneration in the mouse medial septum
BackgroundLow-grade, chronic inflammation in the central nervous system characterized by glial reactivity is one of the major hallmarks for...
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MiRNA-338-3p Inhibits Neuroinflammation in the Corpus Callosum of LCV-LPS Rats Via STAT1 Signal Pathway
Neuroinflammation is a common characteristic of intracranial infection (ICI), which is associated with the activation of astrocytes and microglia....
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The contribution of the meningeal immune interface to neuroinflammation in traumatic brain injury
Traumatic brain injury (TBI) is a major cause of disability and mortality worldwide, particularly among the elderly, yet our mechanistic...
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The Key Drivers of Brain Injury by Systemic Inflammatory Responses after Sepsis: Microglia and Neuroinflammation
Sepsis is a leading cause of intensive care unit admission and death worldwide. Most surviving patients show acute or chronic mental disorders, which...
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Role of Stem Cells and Derived Exosomes as Novel Therapeutic Agents against Neuroinflammation and Stroke
Stroke is a disorder resulting predominantly from the rupture or blockage of blood vessels and is the third primary cause of mortality and disability...
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A Promising Drug Candidate as Potent Therapeutic Approach for Neuroinflammation and Its In Silico Justification of Chalcone Congeners: a Comprehensive Review
Multiple genetic, environmental, and immunological variables cause neuropsychiatric disorders (NPDs). The induced inflammatory immune response is...
