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Establishment and characterization of a novel multidrug-resistant pancreatic ductal adenocarcinoma cell line, PDAC-X1
Drug resistance remains a significant challenge in the treatment of pancreatic cancer. The development of drug-resistant cell lines is crucial to...
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Fisetin and/or capecitabine causes changes in apoptosis pathways in capecitabine-resistant colorectal cancer cell lines
Capecitabine is recommended as one of the first-line chemotherapy treatments for advanced or metastatic colorectal cancer. Researches have been...
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Characterization of a novel glucocorticoid-resistant human B-cell acute lymphoblastic leukemia cell line, with AMPK, mTOR and fatty acid synthesis pathway inhibition
BackgroundAcquired glucocorticoid (GC) resistance remains the main obstacle in acute lymphoblastic leukemia (ALL) therapy. The aim of the present...
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Preparation of Infectious Wolbachia from a Mosquito Cell Line
Eventual genetic engineering of Wolbachia will require maximizing recovery of infectious bacteria, maintaining Wolbachia in a viable state for...
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Upregulation of p300 in paclitaxel-resistant TNBC: implications for cell proliferation via the PCK1/AMPK axis
ObjectiveTo explore the role of p300 in the context of paclitaxel (PTX) resistance in triple-negative breast cancer (TNBC) cells, focusing on its...
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CADM1 impairs the effect of miR-1246 on promoting cell cycle progression in chemo-resistant leukemia cells
The interruption of normal cell cycle execution acts as an important part to the development of leukemia. It was reported that microRNAs (miRNAs)...
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Engineering immunosuppressive drug-resistant armored (IDRA) SARS-CoV-2 T cells for cell therapy
Solid organ transplant (SOT) recipients receive immunosuppressive drugs (ISDs) and are susceptible to develo** severe COVID-19. Here, we analyze...
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Development of a stable Sf9 insect cell line to produce VSV-G pseudotyped baculoviruses
Baculoviruses have shown great potential as gene delivery vectors in mammals, although their effectiveness in transferring genes varies across...
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Establishment and characterization of a new intrahepatic cholangiocarcinoma cell line derived from a Chinese patient
Patients with intrahepatic cholangiocarcinoma (ICC) require chemotherapy due to late detection, rapid disease progression, and low surgical resection...
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First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial
Preclinical evidence has suggested an interplay between the androgen receptor, which largely drives the growth of prostate cancer cells, and...
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Histone modifications in drug-resistant cancers: From a cancer stem cell and immune evasion perspective
The development and immune evasion of cancer stem cells (CSCs) limit the efficacy of currently available anticancer therapies. Recent studies have...
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Proteomics analysis of histone deacetylase inhibitor-resistant solid tumors reveals resistant signatures and potential drug combinations
Histone deacetylase inhibitors (HDACis) are important drugs for cancer therapy, but the indistinct resistant mechanisms of solid tumor therapy...
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Inhaled Adjunct Therapy with Second-Line Drug Candidates for Dose Reduction in Chemotherapeutic Regimens for Multi-drug-Resistant Tuberculosis
Chemotherapy of multi-drug-resistant tuberculosis (TB) requires prolonged administration of multiple drugs. We investigated whether pulmonary...
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Emerging Therapeutic Approaches in Drug-Resistant Breast Cancer
Breast cancer, a heterogeneous and complex disease, remains a significant healthcare challenge around the world, with drug resistance being a major...
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Colorectal cancer organoid models uncover oxaliplatin-resistant mechanisms at single cell resolution
PurposeOxaliplatin-based chemotherapy is a standard treatment for advanced colorectal cancer (CRC) patients. However, chemoresistance-induced...
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PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: a phase 1 trial
Despite recent therapeutic advances, metastatic castration-resistant prostate cancer (mCRPC) remains lethal. Chimeric antigen receptor (CAR) T cell...
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Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer
BackgroundThe impact of non-small cell lung cancer (NSCLC) metabolism on the immune microenvironment is not well understood within platinum...
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Treatment of Castration-Resistant Prostate Cancer
Castration-resistant prostate cancer (CRPC) is a major therapeutic problem. Resistance to androgen deprivation therapy occurs in many patients after...
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High-content analysis identified synergistic drug interactions between INK128, an mTOR inhibitor, and HDAC inhibitors in a non-small cell lung cancer cell line
BackgroundThe development of drug resistance is a major cause of cancer therapy failures. To inhibit drug resistance, multiple drugs are often...
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Does insulin make breast cancer cells resistant to doxorubicin toxicity?
The effects of insulin on the doxorubicin (Dox) sensitivity of breast cancer cell line MCF-7 and its Dox-resistant counterpart MCF-7/Dox were studied...
