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ctDNA and residual cancer burden are prognostic in triple-negative breast cancer patients with residual disease
Triple-negative breast cancer (TNBC) patients with residual disease (RD) after neoadjuvant systemic therapy (NAST) are at high risk for recurrence....
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Association of antibiotic exposure with residual cancer burden in HER2-negative early stage breast cancer
Antibiotic exposure during immunotherapy (IO) has been shown to negatively affect clinical outcomes in various cancer types. The aim of this study...
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The residual cancer burden index as a valid prognostic indicator in breast cancer after neoadjuvant chemotherapy
PurposeThe residual cancer burden index (RCB) was proposed as a response evaluation criterion in breast cancer patients treated with Neoadjuvant...
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Racial disparity in tumor microenvironment and distant recurrence in residual breast cancer after neoadjuvant chemotherapy
Black, compared to white, women with residual estrogen receptor-positive (ER+) breast cancer after neoadjuvant chemotherapy (NAC) have worse distant...
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Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease
Survival from ovarian cancer depends on the resection status after primary surgery. We performed genome-wide association analyses for resection...
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Adjuvant trastuzumab emtansine in HER2-positive breast cancer patients with HER2-negative residual invasive disease in KATHERINE
Following chemotherapy and human epidermal growth factor 2 (HER2)-targeted neoadjuvant therapy for HER2-positive early breast cancer, residual...
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Prediction of residual disease using circulating DNA detection after potentiated radiotherapy for locally advanced head and neck cancer (NeckTAR): a study protocol for a prospective, multicentre trial
BackgroundSensitive and reproducible detection of residual disease after treatment is a major challenge for patients with locally advanced head and...
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Noninvasive oral cancer screening based on local residual adaptation network using optical coherence tomography
AbstractOral cancer is known as one of the relatively common malignancy types worldwide. Despite the easy access of the oral cavity to examination,...
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HER2-low-positive breast cancer: evolution from primary tumor to residual disease after neoadjuvant treatment
Approximately a half of breast tumors classified as HER2-negative exhibit HER2-low-positive expression. We recently described a high instability of...
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Therapy-Induced Dormancy and Residual Disease
In many common epithelial cancers, such as breast and prostate cancer, the majority of deaths are caused by the survival and eventual recurrence of...
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Personalised circulating tumour DNA assay with large-scale mutation coverage for sensitive minimal residual disease detection in colorectal cancer
BackgroundPostoperative minimal residual disease (MRD) detection using circulating-tumour DNA (ctDNA) requires a highly sensitive analysis platform....
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ctDNA and Lung Cancer
The discovery of cell-free DNA (cfDNA) in biofluids such as blood, saliva, urine, and pleural fluid has broadened our understanding of extracellular...
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The utility of ctDNA in detecting minimal residual disease following curative surgery in colorectal cancer: a systematic review and meta-analysis
IntroductionColorectal cancer is the fourth most common cancer in the UK. There remains a need for improved risk stratification following curative...
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Immunotherapy in Breast Cancer
Breast cancer affects 12% of women worldwide. Although advances in systemic, surgical, and radiation therapy approaches will cure a large proportion...
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Molecular residual disease and efficacy of adjuvant chemotherapy in patients with colorectal cancer
Despite standard-of-care treatment, more than 30% of patients with resectable colorectal cancer (CRC) relapse. Circulating tumor DNA (ctDNA) analysis...
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Immunobiology of Cancer
One of the results of three decades of very fast research into the mechanisms of cancer pathogenesis has been the advent of mechanism-based targeted...
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Macrolides for Cancer
Macrolides exert their antitumor effects through various mechanisms. Clarithromycin markedly reduced the incidence of mucosa-associated lymphoid...
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Minimal residual disease profiling predicts pathological complete response in esophageal squamous cell carcinoma
Accurate presurgical prediction of pathological complete response (pCR) can guide treatment decisions, potentially avoiding unnecessary surgeries and...
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Inflammation and Cancer
Virchow (1864) observed that tumor stroma is frequently invaded by inflammatory cells and proposed a relationship between inflammation and cancer for...
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In vivo metabolic imaging identifies lipid vulnerability in a preclinical model of Her2+/Neu breast cancer residual disease and recurrence
Recurrent cancer cells that evade therapy is a leading cause of death in breast cancer patients. This risk is high for women showing an...
