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The impact of breast density notification on rescreening rates within a population-based mammographic screening program
BackgroundHigh participation in mammographic screening is essential for its effectiveness to detect breast cancers early and thereby, improve breast...
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A retrospective analysis of MS/MS screening for IEM in high-risk areas
Inborn errors of metabolism (IEM) can lead to severe motor and neurological developmental disorders and even disability and death in children due to...
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Executive summary of the 14th HHT international scientific conference
Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant vascular disorder characterized by small, dilated clustered vessels...
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Anti-tumor Necrosis Factor-α Antagonists and Tuberculosis
Tumor necrosis factor-α inhibitors (TNFi)TNFiTumor necrosis factor-α inhibitors represent anTumor necrosis factor-α inhibitorsTNFi important advance...
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Screening mammography frequency following dense breast notification among a predominantly Hispanic/Latina screening cohort
PurposeNationally legislated dense breast notification (DBN) informs women of their breast density (BD) and the impact of BD on breast cancer risk...
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Bis(benzonitrile) dichloroplatinum (II) interrupts PD-1/PD-L1 interaction by binding to PD-1
Checkpoint inhibitors such as PD-1/PD-L1 antibody therapeutics are a promising option for the treatment of multiple cancers. Due to the inherent...
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Universal screening for hepatitis C — in for a penny, in for a pound
Infection with hepatitis C virus (HCV) is a major public health problem. In fact, chronic HCV is a leading cause of cirrhosis, hepatocellular...
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Health literacy of people with spinal cord injury: a systematic review
Study designSystematic review.
ObjectiveTo systematically review the evidence on health literacy (HL) of people diagnosed with spinal cord injury...
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HPV testing in Polish population-based cervical cancer screening programme (HIPPO project)—study protocol of a randomised healthcare policy trial
BackgroundAn Organised Cervical Cancer Screening Programme (OCCSP) was started in Poland in 2006/2007. Each woman aged 25 to 59 is eligible for a...
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Determinants of cervical cancer screening utilization among women attending health facilities of Dessie town, Northeast Ethiopia
IntroductionDespite the higher burden of cervical cases, screening programs in highly affected develo** countries remained low. This made the...
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ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells
BackgroundPancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer and the chemotherapies such as gemcitabine/nab-paclitaxel...
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Novel DNA methylation biomarkers in stool and blood for early detection of colorectal cancer and precancerous lesions
BackgroundEarly detection and prevention of precancerous lesions can significantly reduce the morbidity and mortality of colorectal cancer (CRC)....
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Prevalence and genotype distribution of HPV infections among women in Chengdu,China
BackgroundHuman papilloma virus (HPV) infection among female is the cause of cervical cancer and genital warts. In China, the HPV vaccination rate...
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Admission screening and cohort care decrease carbapenem resistant enterobacteriaceae in Vietnamese pediatric ICU’s
ObjectivesTo assess if admission screening for Carbapenem Resistant Enterobacteriaceae (CRE) and cohort care can reduce CRE acquisition (CRE...
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Metagenome-assembled genome reveals species and functional composition of Jianghan chicken gut microbiota and isolation of Pediococcus acidilactic with probiotic properties
BackgroundChickens are one of the most widely farmed animals worldwide and play a crucial role in meat and egg production. Gut microbiota is...
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Anti-osteosarcoma effect of antiserum against cross antigen TPD52 between osteosarcoma and Trichinella spiralis
BackgroundTrichinella spiralis ( T. spiralis ) is a parasite occurring worldwide that has been proven to have antitumour ability. However, studies on...
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Potent antibody-mediated neutralization limits bacteriophage treatment of a pulmonary Mycobacterium abscessus infection
An 81-year-old immunocompetent patient with bronchiectasis and refractory Mycobacterium abscessus lung disease was treated for 6 months with a...
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Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells
Prime editing (PE) enables precise and versatile genome editing without requiring double-stranded DNA breaks. Here we describe the systematic...
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Visual inspection with acetic acid (VIA) positivity among female sex workers: a cross-sectional study highlighting one-year experiences in early detection of pre-cancerous and cancerous cervical lesions in Kampala, Uganda
BackgroundAlthough cervical cancer is preventable, most women in sub-Saharan Africa (SSA) do not receive routine screening and few treatment options...
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Immunogenicity Risk Assessment for Multi-specific Therapeutics
The objective of this manuscript is to provide the reader with a hypothetical case study to present an immunogenicity risk assessment for a...
