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Reproducible Abnormalities and Diagnostic Generalizability of White Matter in Alzheimer’s Disease
Alzheimer’s disease (AD) is associated with the impairment of white matter (WM) tracts. The current study aimed to verify the utility of WM as the...
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Sensitive and reproducible MEG resting-state metrics of functional connectivity in Alzheimer’s disease
BackgroundAnalysis of functional brain networks in Alzheimer’s disease (AD) has been hampered by a lack of reproducible, yet valid metrics of...
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Alzheimer’s Disease Methods and Protocols
This volume explores the latest techniques used to study the human brain towards understanding Alzheimer’s Disease and related neurodegenerative...
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Extracellular Vesicles in Coronary Artery Disease
Coronary artery disease (CAD) is the leading cause of death and disability worldwide. Despite recent progress in the diagnosis and treatment of CAD,...
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Functional Brain Networks to Evaluate Treatment Responses in Parkinson’s Disease
Network analysis of functional brain scans acquired with [ 18 F]-fluorodeoxyglucose positron emission tomography (FDG PET, to map cerebral glucose...
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Reproducible and opposing gut microbiome signatures distinguish autoimmune diseases and cancers: a systematic review and meta-analysis
BackgroundThe gut microbiome promotes specific immune responses, and in turn, the immune system has a hand in sha** the microbiome. Cancer and...
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Borna Disease (Borna Disease Virus-1, BoDV-1)
In this chapter, we describe the virologic and diagnostic aspects of Borna disease virus 1 (BoDV-1), the clinical presentation, epidemiology,...
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Borna Disease (Borna Disease Virus-1, BoDV-1)
In this chapter, we describe the virologic and diagnostic aspects of Borna disease virus 1 (BoDV-1), the clinical presentation, epidemiology,...
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Inflammation Biomarkers in Huntington’s Disease
Neurodegenerative diseases share many features, such as inflammation. Accumulating evidence support the role of neuroinflammation in the pathogenesis...
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Smelling the Disease: Diagnostic Potential of Breath Analysis
Breath analysis is a relatively recent field of research with much promise in scientific and clinical studies. Breath contains endogenously produced...
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Metabolic Networks in Parkinson’s Disease
Our understanding of Parkinson’s disease (PD) has progressed from a focal disorder primarily of the basal ganglia to a more widespread “network”...
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Deciphering Congenital Heart Disease Using Human Induced Pluripotent Stem Cells
Congenital heart disease (CHD) is a leading cause of birth defect-related death. Despite significant advances, the mechanisms underlying the...
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Enzymatic Biosensor Platforms for Infectious Disease Diagnosis: Focus on Tuberculosis and Neglected Tropical Diseases
Infectious diseases affect millions worldwide and report high mortality rates with antimicrobial resistance hazards. Effective and affordable...
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Animal Models for the Study of Human Disease
The use of conventional healthy animals (CHAs) has long been a mainstay of nonclinical safety testing as well as evaluation of efficacy of new...
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Reproducible Evaluation of Diffusion MRI Features for Automatic Classification of Patients with Alzheimer’s Disease
Diffusion MRI is the modality of choice to study alterations of white matter. In past years, various works have used diffusion MRI for automatic...
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Metabolomics in Huntington’s Disease
Metabolomics approaches have been used to gain new insights and to identify potential biomarkers in Huntington’s disease (HD) for almost two decades....
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Proteomics in Huntington’s Disease Biomarker Discovery
Mass spectrometry (MS) and proteomics are continuously evolving methods in systems biology that carry enormous potential for accurately profiling the...
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Alzheimer’s Disease
Alzheimer’s disease (AD) represents the most prevalent form of senile dementias. The disease is characterized by the occurrence of extracellular...
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Modified Investigation Tools and Techniques Useful in Alzheimer’s Disease Research
Alzheimer’s disease is a predominant cerebral disease of uncertain etiology with distinctive neuropathological and neurochemical characteristics. It...
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Microbiome and Metabolomic Biomarkers for Huntington’s Disease
Huntington’s disease (HD) is a fatal monogenic neurodegenerative disorder caused by the expansion of the trinucleotide tandem repeat in the...