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Washed microbiota transplantation improves renal function in patients with renal dysfunction: a retrospective cohort study
BackgroundChanges in the gut microbiota composition is a hallmark of chronic kidney disease (CKD), and interventions targeting the gut microbiota...
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DNA methylation in peripheral blood is associated with renal aging and renal function decline: a national community study
BackgroundOlder patients are at risk for acute kidney injury and chronic kidney disease. Age-related increases in DNA methylation at CpG islands have...
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Association between decreased ipsilateral renal function and aggressive behavior in renal cell carcinoma
BackgroundTo assess prognostic value of pre-operative ipsilateral split renal function (SRF) on disease-free survival (DFS) and its association with...
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Transcutaneous measurement of renal function in two rodent models of obstructive nephropathy
ObjectiveGlomerular filtration rate (GFR) is a key indicator of renal function. In both clinical practice and pre-clinical research, serum levels of...
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Associations of Blood and Cerebrospinal Fluid Aβ and tau Levels with Renal Function
Amyloid β (Aβ) and tau play pivotal roles in the pathogenesis of Alzheimer’s disease (AD). Previous studies have shown that brain-derived Aβ and tau...
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Association of neurofilament light chain with renal function: mechanisms and clinical implications
BackgroundBlood-based neurofilament light chain (NfL) is a promising biomarker of neurodegeneration across multiple neurodegenerative diseases....
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Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients
BackgroundTregs trafficking is controlled by CXCR4. In Renal Cell Carcinoma (RCC), the effect of the new CXCR4 antagonist, R54, was explored in...
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Study on the mechanism of hirudin multi target delaying renal function decline in chronic kidney disease based on the “gut-kidney axis” theory
The disorder of the “gut-kidney axis” exacerbates renal function decline in chronic kidney disease (CKD), and current CKD therapy is insufficient to...
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Renal Physiology and Hydrosaline Metabolism
This volume discusses renal function and the mechanisms by which the kidney regulates the composition and volume of the extracellular fluid. It also...
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Real-World Effects of Biologics on Renal Function in Psoriatic Patients: A Retrospective Study
BackgroundPatients with severe psoriasis are prone to deterioration of renal function. Whether biologics with potent anti-inflammatory action can...
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Prospective affirmative therapeutics of cannabidiol oil mitigates doxorubicin-induced abnormalities in kidney function, inflammation, and renal tissue changes
Nephropathy is the decline in kidney function. A promising treatment for numerous types of illness is using natural materials as natural chemical...
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DsbA-L ameliorates renal aging and renal fibrosis by maintaining mitochondrial homeostasis
Renal fibrosis is the final pathological change in renal disease, and aging is closely related to renal fibrosis. Mitochondrial dysfunction has been...
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Hyperthermia inhibits cellular function and induces immunogenic cell death in renal cell carcinoma
BackgroundIn recent years, hyperthermia has been widely applied as a novel strategy for cancer treatment due to its multiple antitumour effects. In...
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Novel pathogenic variants in CUBN uncouple proteinuria from renal function
BackgroundProteinuria is an unfavorable clinical condition highly associated with a risk of renal and cardiovascular disease in chronic kidney...
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Extracellular Vesicle Biomarkers for Renal Diseases
Extracellular vesicles (EVs) are emerging as a new mechanism of intercellular communication in renal disease. EVs originating from the renal system...
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Levamisole Impairs Vascular Function by Blocking α-Adrenergic Receptors and Reducing NO Bioavailability in Rabbit Renal Artery
Levamisole is an anthelmintic drug restricted to veterinary use but is currently detected as the most widely used cocaine cutting agent in European...
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Renal function and lipid metabolism in Japanese HIV-1-positive individuals 288 weeks after switching from tenofovir disoproxil fumarate to tenofovir alafenamide fumarate: a single-center, retrospective cohort study
BackgroundContinued use of tenofovir disoproxil fumarate (TDF), an antiretroviral drug, causes renal function decline and tubular damage in...
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Association between tenofovir plasma trough concentrations in the early stage of administration and discontinuation of up to five years tenofovir disoproxil fumarate due to renal function-related adverse events in Japanese HIV-1 infected patients
BackgroundThe relationship between plasma tenofovir (TFV) concentration at the beginning of tenofovir disoproxil fumarate (TDF) administration and...
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Prognosis and biological function of SGOL1 in clear cell renal cell carcinoma: a multiomics analysis
BackgroundShugoshin-1 (SGOL1) is a mammalian ortholog of Shugoshin in yeast and is essential for precise chromosome segregation during mitosis and...
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Renal Cell Carcinomas
This chapter highlights the molecular mechanisms in some of the many different tumor types that originate in the adult kidney. Renal cell carcinomas...