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Drug Release
Drug release from dosage forms (also termed drug liberation) is a prerequisite for absorption to occur: only free molecules in solution can cross...
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Molecular Mechanisms of Neurotransmitter Release
Neurons communicate with each other by releasing neurotransmitters. This book provides comprehensive coverage of the molecular mechanisms involved in...
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Modified Release Solid Oral Dosage Forms
This chapter presents an extensive overview of the concepts of delayed-release, sustained-release, and pulsatile-release for drug delivery....
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Evaluation of Dose-Response Relationship of Permeation Enhancer Isopropyl Myristate Release on Drug Release: Release Enhancement Efficiency and Molecular Mechanism
The objective of this study is to investigate the dose-response relationship between various concentrations of permeation enhancers (PEs) and their...
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Development of Amorphous Solid Dispersion Sustained-Release Formulations with Polymer Composite Matrix-Regulated Stable Release Plateaus
PurposeThis study was designed to develop ibuprofen (IBU) sustained-release amorphous solid dispersion (ASD) using polymer composites matrix with...
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Calcium Sensors of Neurotransmitter Release
Calcium (Ca2+) plays a critical role in triggering all three primary modes of neurotransmitter release (synchronous, asynchronous, and spontaneous)....
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Transdermal Delivery of Estradiol Simultaneously Possessing Rapid Release and Sustained Release Effect
Dissolving microneedle (DMN) has been researched as a drug delivery technology that improves drug molecule transportation through the skin with...
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Drug Release from Surfactant-Containing Amorphous Solid Dispersions: Mechanism and Role of Surfactant in Release Enhancement
PurposeTo understand how surfactants affect drug release from ternary amorphous solid dispersions (ASDs), and to investigate different mechanisms of...
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Development of Drug Release Model for Suspensions in ESCAR (Emulator of SubCutaneous Absorption and Release)
We recently developed an in vitro testing system, namely, ESCAR (Emulator of SubCutaneous Absorption and Release). The objective of this work was to...
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Regulation of Neurotransmitter Release by K+ Channels
K+ channels play potent roles in the process of neurotransmitter release by influencing the action potential waveform and modulating neuronal...
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Grasp and Release Test for Tetraplegic Hand Assessment: an update of the Grasp and Release Test
The Grasp and Release Test (GRT) was originally developed to measure effectiveness of an implanted neuroprosthesis in people with tetraplegia. Its...
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The Architecture of the Presynaptic Release Site
The architecture of the presynaptic release site is exquisitely designed to facilitate and regulate synaptic vesicle exocytosis. With the...
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Assessment of Temperature-Dependent Drug Release of Solubilizing Nanoformulations Using the SITUA
The evaluation of temperature-dependent drug release for solubilizing nanoformulations uses a modification of the stable isotope ultrafiltration...
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Release of Antibodies and Cytokines from B Cells
Autoreactive B cells play a critical role in rheumatoid arthritis (RA). These cells differentiate into long-living memory B cells and...
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Extracellular release in the quality control of the mammalian mitochondria
Mammalian cells release a wealth of materials to their surroundings. Emerging data suggest these materials can even be mitochondria with perturbed...
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Development, Physicochemical Characteristics and Pharmacokinetics of a New Sustained-Release Bilayer Tablet Formulation of Tramadol with an Immediate-Release Component for Twice-Daily Administration
Background and ObjectiveThere are some potential concerns about the currently marketed solid oral dosage forms of tramadol, including decreased...
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Measuring Presynaptic Release Probability
Measuring the probability of neurotransmitter releaseNeurotransmitter release (Pr) at chemical synaptic connections can provide valuable insights as...
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Sustained release delivery of favipiravir through statistically optimized, chemically cross-linked, pH-sensitive, swellable hydrogel
In the current work, favipiravir (an antiviral drug) loaded pH-responsive polymeric hydrogels were developed by the free redical polymerization...
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Imaging Neuropeptide Release at Drosophila Neuromuscular Junction with a Genetically Engineered Neuropeptide Release Reporter
Despite the important roles of neuropeptides in a variety of physiological processes, there still lacks a method to probe neuropeptide release events...