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Drug Distribution
Once in systemic circulation, the drug molecules will extravasate to other tissues, including the targeted organ(s), a process that we will refer to...
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Discrepancy between distribution of alpha-synuclein oligomers and Lewy-related pathology in Parkinson’s disease
The pathological hallmarks of Parkinson’s disease (PD) are α-synuclein (αSYN)-positive inclusions referred to as Lewy bodies and Lewy neurites,...
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The distribution of neuroligin4, an autism-related postsynaptic molecule, in the human brain
NLGN4X was identified as a single causative gene of rare familial nonsyndromic autism for the first time. It encodes the postsynaptic membrane...
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Sex-related differences in safety profiles, pharmacokinetics and tissue distribution of sinomenine hydrochloride in rats
Sinomenine is a bioactive alkaloid isolated from the Chinese medicinal plant Sinomenium acutum (Thunb.) Rehd. et Wils which exhibits significant...
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Distribution of Lewy-related pathology in the brain, spinal cord, and periphery: the population-based Vantaa 85 + study
Evolving evidence has supported the existence of two anatomically distinct Lewy-related pathology (LRP) types. Investigation of spinal cord and...
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Pain-Related Evoked Potentials
Laser-evoked brain potentials (LEPs) are brain responses elicited by the brief activation of heat-sensitive skin nociceptors and their spinothalamic...
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Event-Related Potentials (ERPs) and Event-Related Fields (ERFs)
Evoked responses (ERs) are a set of event-related small changes in voltage or magnetic field measured from the brain that arise in time- and...
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TEP SNORD12B, SNORA63, and SNORD14E as novel biomarkers for hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC)
PurposeThe alterations of RNA profile in tumor-educated platelets (TEPs) have been described as a novel biosource for cancer diagnostics. This study...
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Preliminary analysis of immune-related markers in thymic carcinoid
The immune-related microenvironment of thymic carcinoid has rarely been reported. We analyzed the expression of PD-L1 and VISTA, and the distribution...
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Antioxidants-related nuclear factor erythroid 2-related factor 2 gene variants associated with HBV-related liver disease
BackgroundAccumulating evidence demonstrated that nuclear factor erythroid 2-related factor 2 (NRF2) expression plays a crucial role in the...
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Distribution, Metabolism, and Excretion of Cenobamate in Adult, Fetal, Neonatal, and Lactating Rats
Background and ObjectiveCenobamate is an antiseizure medication (ASM) approved for treatment of focal epilepsy in adults. The objective of this...
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Age-related differences in resting-state, task-related, and structural brain connectivity: graph theoretical analyses and visual search performance
Previous magnetic resonance imaging (MRI) research suggests that aging is associated with a decrease in the functional interconnections within and...
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The role of blood related inflammatory factors on age-related macular degeneration (AMD)
BackgroundAge-related macular degeneration (AMD) is a significant retinal disease that leads to irreversible low vision, particularly in develo**...
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Progesterone receptor distribution in the human hypothalamus and its association with suicide
The human hypothalamus modulates mental health by balancing interactions between hormonal fluctuations and stress responses. Stress-induced...
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Phosphodiesterase 8 (PDE8): Distribution and Cellular Expression and Association with Alzheimer’s Disease
Phosphodiesterase 8 (PDE8), as a member of PDE superfamily, specifically promotes the hydrolysis and degradation of intracellular cyclic adenosine...
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Prevalence, distribution, and severity of cerebral amyloid angiopathy differ between Lewy body diseases and Alzheimer’s disease
Dementia with Lewy bodies (DLB), Parkinson’s disease dementia (PDD), and Parkinson’s disease (PD) collectively known as Lewy body diseases (LBDs) are...
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Distribution: Across Barriers
Distribution of drugs across barriers plays a predominant role in the processes of absorption (A), distribution (D), and excretion (E) and is thus a...
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Cellular Senescence-Related Long Non-coding RNA Signatures Predict Prognosis in Juvenile Osteosarcoma
Osteosarcoma is the most common malignant bone tumor and is frequently diagnosed in juvenile. Cellular senescence is a fundamental hallmark of...
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Measuring quality of facility-based ITN distribution in Ghana
BackgroundContinuous distribution channels are effective methods to deliver malaria interventions such as insecticide treated nets (ITNs) to pregnant...
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Product-Related Impurities in Therapeutic Virus Bioprocessing
Viral vectors are manufactured into drug products for therapeutic uses. Efforts must be undertaken to ensure sufficient understanding of the...