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Regulatory T-Cells Methods and Protocols
This volume provides methods and models for investigating the immunosuppressive subset of CD4+ T-cells, regulatory T-cells (Treg). Chapters guide...
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Brain regulatory T cells
The brain, long thought to be isolated from the peripheral immune system, is increasingly recognized to be integrated into a systemic immunological...
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Regulatory T Cells for Control of Autoimmunity
Regulatory T (Treg) cells, which specifically express the master transcription factor FoxP3, are indispensable for the maintenance of immunological...
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Intravital Imaging of Regulatory T Cells in Inflamed Skin
Regulatory T cells play key roles in skin homeostasis and inflammation and in regulating antitumor responses. Understanding of the biology of this...
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Redirecting Human Conventional and Regulatory T Cells Using Chimeric Antigen Receptors
The adaptive immune system exhibits exquisite specificity and memory and is involved in virtually every process in the human body. Redirecting...
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Regulatory T cells limit age-associated retinal inflammation and neurodegeneration
BackgroundAgeing is the principal risk factor for retinal degenerative diseases, which are the commonest cause of blindness in the developed...
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The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases
The discovery of FOXP3 + regulatory T (T reg ) cells as a distinct cell lineage with a central role in regulating immune responses provided a deeper...
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Role of Regulatory T Cells in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a common cerebrovascular disease that can lead to severe neurological dysfunction in surviving patients, resulting...
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Regulatory T cells in the face of the intestinal microbiota
Regulatory T cells (T reg cells) are key players in ensuring a peaceful coexistence with microorganisms and food antigens at intestinal borders....
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A T follicular helper cell origin for T regulatory type 1 cells
Chronic antigenic stimulation can trigger the differentiation of antigen-experienced CD4 + T cells into T regulatory type 1 (TR1) cells, a subset of...
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Evaluation of the Suppressive Capacity of Regulatory T Cells in Food Allergy Research
Regulatory T cells (Treg) exert a crucial role in the suppression of exacerbated T helper (Th) cell responses, including those of type 2 Th (Th2)...
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In Vitro Analysis of CTLA-4-Mediated Transendocytosis by Regulatory T Cells
Regulatory T Cells (Tregs)Regulatory T cells (Tregs) constitutively express the inhibitory receptor CTLA-4, which is fundamental to their role in...
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Aged hematopoietic stem cells entrap regulatory T cells to create a prosurvival microenvironment
Although DNA mutation drives stem cell aging, how mutation-accumulated stem cells obtain clonal advantage during aging remains poorly understood....
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IFNγ-induction of TH1-like regulatory T cells controls antiviral responses
Regulatory T (T reg ) cells are an immunosuppressive population that are required to maintain peripheral tolerance and prevent tissue damage from...
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Induced regulatory T cells remain suppressive capability on effector T cells and synovial fibroblasts in collagen-induced arthritis
Rheumatoid arthritis (RA) is a common autoimmune disorder initiated by inflammatory synovitis. Hyperproliferation of destructive synovial fibroblasts...
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Regulatory T-Cell Phenoty** Using CyTOF
Regulatory T cellsRegulatory T cells (Tregs) are an important component of the immune system that plays a key role in maintaining homeostasis....
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IL-2 immunotherapy for targeting regulatory T cells in autoimmunity
FOXP3 + regulatory T cells (T reg ) are indispensable for immune homoeostasis and for the prevention of autoimmune diseases. Interleukin-2 (IL-2)...
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Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity
Regulatory T cells (T reg cells) are instrumental in establishing immunological tolerance. However, the precise effector mechanisms by which T reg ...
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Lipid metabolism in tumor-infiltrating regulatory T cells: perspective to precision immunotherapy
Regulatory T cells (Tregs) are essential to the negative regulation of the immune system, as they avoid excessive inflammation and mediate tumor...
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Semaphorin 3 a restores the ability of type 1 regulatory T cells to suppress food allergy
Food allergy (FA) is a common immune disorder that involves dysfunctional immune regulation. More remedies for restoring immune regulation are...
