Search
Search Results
-
Thioredoxin is a metabolic rheostat controlling regulatory B cells
Metabolic programming is important for B cell fate, but the bioenergetic requirement for regulatory B (B reg ) cell differentiation and function is...
-
Regulatory B Cells Methods and Protocols
This second edition provides new and updated chapters useful for the study of Regulatory B cells. Organized in four sections,...
-
Investigating the impact of regulatory B cells and regulatory B cell-related genes on bladder cancer progression and immunotherapeutic sensitivity
BackgroundRegulatory B cells (Bregs), a specialized subset of B cells that modulate immune responses and maintain immune tolerance in malignant...
-
Isolation and Single-Cell Transcriptomic Analysis of Murine Regulatory B Cells
Regulatory B (Breg) cells have been demonstrated to play an important role in the inhibition of a wide range of immunological responses, and they are...
-
Immuno-regulatory malignant B cells contribute to Chronic Lymphocytic Leukemia progression
Chronic Lymphocytic Leukemia (CLL) is a heterogeneous B cell neoplasm ranging from indolent to rapidly progressive disease. Leukemic cell subsets...
-
B-Cell-Activating Factor Contributes to Elevation of the Content of Regulatory B Cells in Neonatal Sepsis
We studied the role of B cell-activating factor (BAFF) in PI3K/AKT/mTOR signaling pathway in promoting proliferation and maintaining survival of...
-
Glutaminolysis is required in maintaining immune regulatory functions in B cells
IL-10-expressing regulatory B cells (B10 cells) are dysfunctional in patients with many immune disorders. The underlying mechanism remains to be...
-
B-cells and regulatory T-cells in the microenvironment of HER2+ breast cancer are associated with decreased survival: a real-world analysis of women with HER2+ metastatic breast cancer
BackgroundDespite major improvements in treatment of HER2-positive metastatic breast cancer (MBC), only few patients achieve complete remission and...
-
B Cells and Antibody Production in Cancer
B cells and their products play a key role in the development and progression of cancers, with pro- and antitumoral functions in the tumor...
-
Release of Antibodies and Cytokines from B Cells
Autoreactive B cells play a critical role in rheumatoid arthritis (RA). These cells differentiate into long-living memory B cells and...
-
Regulatory B Cells in Type 1 Diabetes
Type 1 diabetes is an organ-specific autoimmune disease characterized by immune-mediated beta cell destruction in pancreatic islets, which results in...
-
Methods to Study the Transcriptome of Regulatory B Cells
Regulatory B cells do not constitute a distinct cell lineage because no unique marker or set of markers can exclusively identify neither murine nor...
-
Regulatory and IgE+ B Cells in Allergic Asthma
Allergic asthma is triggered by inhalation of environmental allergens resulting in bronchial constriction and inflammation, which leads to clinical...
-
PI3K Isoforms in B Cells
Phosphatidylinositol-3-kinases (PI3K) control many aspects of cellular activation and differentiation and play an important role in B cells biology....
-
PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells
The differentiation of naive and memory B cells into antibody-secreting cells (ASCs) is a key feature of adaptive immunity. The requirement for...
-
Non-canonical transcriptional regulation of the poor prognostic factor UGT2B17 in chronic lymphocytic leukemic and normal B cells
BackgroundHigh expression of the glycosyltransferase UGT2B17 represents an independent adverse prognostic marker in chronic lymphocytic leukemia...
-
Oxidative stress-initiated one-carbon metabolism drives the generation of interleukin-10-producing B cells to resolve pneumonia
The metabolic reprogramming underlying the generation of regulatory B cells during infectious diseases remains unknown. Using a Pseudomonas aeruginosa ...
-
A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in B-lineage cells
SATB1 (Special A-T rich Binding protein 1) is a cell type-specific factor that regulates the genetic network in develo** T cells and neurons. In T...
-
Canine diffuse large B-cell lymphoma downregulates the activity of CD8 + T-cells through tumor-derived extracellular vesicles
BackgroundTumor-derived extracellular vesicles (EVs) have been proposed as the essential mediator between host immunity and cancer development. These...
-
Analysis of Regulatory B Cells in Experimental Autoimmune Uveitis
Regulatory B cells (Bregs) that produce IL-35 and IL-10 (i35-Bregs) regulate central nervous system (CNS) autoimmune diseases including uveitis. In...