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Reference Materials for Improving Reliability of Multiomics Profiling
High-throughput technologies for multiomics or molecular phenomics profiling have been extensively adopted in biomedical research and clinical...
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Development of preimplantation genetic testing for monogenic reference materials using next-generation sequencing
ObjectivePreimplantation genetic testing for monogenic disorders (PGT-M) has been used for over 20 years to detect many serious genetic conditions....
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EU surveys insights: analytical tools, future directions, and the essential requirement for reference materials in wastewater monitoring of SARS-CoV-2, antimicrobial resistance and beyond
BackgroundWastewater surveillance (WWS) acts as a vigilant sentinel system for communities, analysing sewage to protect public health by detecting...
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Referencing: Use of Reference Manager
Referencing in research is a critical aspect of academic writing. It involves citing the sources of information and ideas we have used in the... -
Reference Standards to Support Quality of Synthetic Peptide Therapeutics
PurposePeptides are an important class of therapeutics. Their quality is evaluated using a series of analytical tests, many of which depend on...
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The reference range of lamotrigine in the treatment of epilepsy in children: a systematic review
PurposeThis study intends to assess the reference range of lamotrigine concentration for treating childhood epilepsy.
MethodsPubMed, Ovid-Embase,...
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Reference-free inferring of transcriptomic events in cancer cells on single-cell data
BackgroundCancerous cells’ identity is determined via a mixture of multiple factors such as genomic variations, epigenetics, and the regulatory...
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Reference Gene Validation in the Embryonic and Postnatal Brain in the Rat Hyperhomocysteinemia Model
Maternal hyperhomocysteinemia (HCY) induced by genetic defects in methionine cycle enzymes or vitamin imbalance is known to be a pathologic factor...
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Food Contact Materials
Food contact materials (FCM) are all materials and articles intended to come into direct or indirect contact with food. The definition of food... -
Full-Length Characterization of Novel HLA-DRB1 Alleles for Reference Database Submission
The prerequisite for successful HLA genoty** is the integrity of the large allele reference database IPD-IMGT/HLA. Consequently, it is in the... -
Retrograde amnesia abolishes the self-reference effect in anterograde memory
Is retrograde amnesia associated with an ability to know who we are and imagine what we will be like in the future? To answer this question, we had...
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A Reference Standard for Analytical Testing of Erythropoietin
PurposeErythropoietin (EPO) is a 165 amino acid protein that promotes the proliferation of erythrocytic progenitors. A decrease in endogenous EPO...
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Reference intervals for plasma amyloid-β, total tau, and phosphorylated tau181 in healthy elderly Chinese individuals without cognitive impairment
BackgroundPlasma amyloid-β (Aβ) peptides and tau proteins are promising biomarkers of Alzheimer’s disease (AD), not only for predicting Aβ and tau...
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Reference genome assemblies reveal the origin and evolution of allohexaploid oat
Common oat ( Avena sativa ) is an important cereal crop serving as a valuable source of forage and human food. Although reference genomes of many...
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Calibration of a serum reference standard for Group B streptococcal polysaccharide conjugate vaccine development using surface plasmon resonance
Group B streptococcus (GBS) is a leading cause of neonatal morbidity and mortality worldwide. Development of a maternal vaccine to protect newborns...
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Demonstration of Physicochemical and Functional Similarity of the Biosimilar BAT1806/BIIB800 to Reference Tocilizumab
Background and ObjectiveTocilizumab is an immunoglobulin G1 monoclonal antibody targeting the interleukin-6 receptor (IL-6R). BAT1806/BIIB800...
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Population pharmacokinetic, pharmacodynamic and efficacy modeling of SB12 (proposed eculizumab biosimilar) and reference eculizumab
PurposeTo describe, compare similarity of pharmacokinetic (PK), pharmacodynamic (PD) and efficacy of SB12 and reference eculizumab (ECU) and find...
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Patterns in the Public Square: Reference Models for Regulatory Science
Science and engineering involve discovery, representation, explanation, and exploitation of recurrent patterns, observed as phenomena. Model-based...
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Reference values for estimated VO2max by two submaximal cycle tests: the Åstrand-test and the Ekblom-Bak test
AimsSubmaximal tests estimating VO 2 max have inherent biases; hence, using VO 2 max estimations from the same test is essential for reducing this...
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An algorithm for visceral leishmaniasis diagnosis in Brazil from a 10-year analysis of National Reference Laboratory data
Visceral leishmaniasis (VL) requires diagnostic assays to complement clinical suspicion. However, there is no standardization of a diagnostic flow...