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Not recommended fixed-dose antibiotic combinations in low- and middle-income countries – the example of Tanzania
BackgroundFixed-dose combinations (FDC) are medicine formulations that combine two or more ingredients in fixed ratios in a single dose form....
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Implicit signatures of voluntary action reduce with repeated motor practice
The sense of controlling one’s actions and their consequences is a critical aspect of successful motor activity. While motor performance typically...
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Striatal dopamine signals reflect perceived cue–action–outcome associations in mice
Striatal dopamine drives associative learning by acting as a teaching signal. Much work has focused on simple learning paradigms, including Pavlovian...
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Cognitive Impairment and Nootropic Drugs: Mechanism of Action and Spectrum of Effects
Abstract —This review provides information about the features of cognitive dysfunctions that occur in various diseases and conditions, and data on the...
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Recommended tool compounds and drugs for blocking P2X and P2Y receptors
This review article presents a collection of tool compounds that selectively block and are recommended for studying P2Y and P2X receptor subtypes,...
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Key informant perspectives on implementing genomic newborn screening: a qualitative study guided by the Action, Actor, Context, Target, Time framework
Newborn screening (NBS) programmes are highly successful, trusted, public health interventions. Genomic sequencing offers the opportunity to increase...
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A review of national action plans on antimicrobial resistance: strengths and weaknesses
BackgroundThe World Health Organization developed the Global Action Plan on Antimicrobial resistance (AMR) as a priority because of the increasing...
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Identifying opportunities for collective action around community nutrition programming through participatory systems science
PurposeTo apply principles of group model building (GMB), a participatory systems science approach, to identify barriers and opportunities for...
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Left anterior supramarginal gyrus activity during tool use action observation after extensive tool use training
The advanced use of complex tools is considered a primary characteristic of human evolution and technological advancement. However, questions remain...
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Essential tremor impairs the ability to suppress involuntary action impulses
Essential tremor (ET) is a movement disorder characterized primarily by action tremor which affects the regulation of movements. Disruptions in...
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The electrical restitution of the non-propagated cardiac ventricular action potential
Sudden changes in pacing cycle length are frequently associated with repolarization abnormalities initiating cardiac arrhythmias, and physiologists...
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Health system barriers to the implementation of the national action plan to combat antimicrobial resistance in Vietnam: a sco** review
BackgroundVietnam is among 11 countries in the Western Pacific region that has developed a National Action Plan for Antimicrobial Resistance (NAPCA).
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Neural correlates of embodied action language processing: a systematic review and meta-analytic study
The neural correlates of action language processing are still debated within embodied cognition research and little is known about the flexible...
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Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBi**g, a Chinese herb-based intravenous formulation
Sepsis, a life-threatening health issue, lacks effective medicine targeting the septic response. In China, treatment combining the intravenous herbal...
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Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study
Metformin, a biguanide drug, is the most commonly used first-line medication for type 2 diabetes mellites due to its outstanding glucose-lowering...
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How drug onset rate and duration of action affect drug forgiveness
Medication nonadherence is one of the largest problems in healthcare today, particularly for patients undergoing long-term pharmacotherapy. To combat...
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Cancer Therapeutics: Mechanism of Action, Radiation Toxicity, and Drug Formulation
Cancer is a well-known disease that involves complex changes in the genome due to variation in host and environment, and it is also a prime cause of...
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A Comparison Study of Medicinal Plants Used Against SARS-CoV-2 and Those Recommended Against Malaria in Africa
Coronavirus disease 2019 (COVID-19) and malaria are two different diseases but both lead to serious crisis in public health in Africa. These two...
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Motor and non-motor symptoms, drugs, and their mode of action in Parkinson’s disease (PD): a review
Parkinson’s disease is second most common neurodegenerative disorder neurological illness that primarily affects patients in their later years of...
