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Engineering a Remedy to Modulate and Optimize Biopharmaceutical Properties of Rebamipide by Synthesizing New Cocrystal: In Silico and Experimental Studies
PurposeRebamipide (REB) a potent anti-ulcer agent, has not been exploited to its full potential, owing to it extremely poor solubility, leading to...
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Effect of gastric residence time on the oral absorption of rebamipide sustained-release tablets in beagle dogs
PurposeRebamipide (RBM) is known to have a specific absorption window in the upper GI tract. However, there have been no in vivo studies reporting...
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Establishment of a humanized animal model of systemic sclerosis in which T helper-17 cells from patients with systemic sclerosis infiltrate and cause fibrosis in the lungs and skin
Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by inflammation, microangiopathy, and progressive fibrosis in the skin and...
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The effectiveness of rebamipide mouthwash therapy for radiotherapy and chemoradiotherapy-induced oral mucositis in patients with head and neck cancer: a systematic review and meta-analysis
BackgroundOral mucositis is a frequent and severe adverse event in patients undergoing chemoradiotherapy for head and neck cancers, especially grade...
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Lipid Nanoemulsions of Rebamipide: Formulation, Characterization, and In Vivo Evaluation of Pharmacokinetic and Pharmacodynamic Effects
Rebamipide has low oral bioavailability (10%) due to its low solubility and permeability. Lipid nanoemulsions (LNEs) were prepared in order to...
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Rebamipide Mitigates Impairments in Mitochondrial Function and Bioenergetics with α-Synuclein Pathology in 6-OHDA-Induced Hemiparkinson’s Model in Rats
Parkinson’s disease (PD) is one of the widely reported neurodegenerative disorders affecting more than ten million people worldwide. Due to...
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Berberine mitigates diclofenac-induced intestinal mucosal mechanical barrier dysfunction through the restoration of autophagy by inhibiting exosome-mediated lncRNA H19
Small intestine damage caused by diclofenac is called diclofenac enteropathy. Berberine (BBR), a class of isoquinoline alkaloids derived from...
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Drugs Used in Acid Peptic Disorders
With the modernization of lifestyle, dyspepsia becomes one of the common symptoms worldwide. Polypharmacy due to various comorbidities, alcoholism,...
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Clinical features, treatment, and outcome of pembrolizumab induced cholangitis
Pembrolizumab induced hepatitis has received increasing attention, while pembrolizumab induced cholangitis is poorly understood. This study...
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Medication use before and during pregnancy in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
PurposeTo elucidate the status of medication use among pregnant women in Japan, by means of a multigenerational genome and birth cohort study: the...
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Recovery from indomethacin-induced gastrointestinal bleeding by treatment with teprenone
BackgroundGastrointestinal injuries caused by nonsteroidal anti-inflammatory drugs (NSAIDs) is a serious side effect in patients with rheumatoid...
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Intra-articular injection of stigmasterol-loaded nanoparticles reduce pain and inhibit the inflammation and joint destruction in osteoarthritis rat model: A pilot study
Stigmasterol, a plant-derived sterol, sharing structural similarity with cholesterol, has demonstrated anti-osteoarthritis (OA) properties,...
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Ocular Drug Delivery: a Comprehensive Review
The human eye is a sophisticated organ with distinctive anatomy and physiology that hinders the passage of drugs into targeted ophthalmic sites....
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Characterization and Evaluation of the Solubility and Oral Bioavailability of Rutin–Ethanolate Solvate
Rutin has many biological activities, but poor solubility and absorption limit its oral application. This study aimed to investigate the...
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PLD1 is a key player in cancer stemness and chemoresistance: Therapeutic targeting of cross-talk between the PI3K/Akt and Wnt/β-catenin pathways
The development of chemoresistance is a major challenge in the treatment of several types of cancers in clinical settings. Stemness and...
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Using human iPS cell-derived enterocytes as novel in vitro model for the evaluation of human intestinal mucosal damage
Objective and designThe primary component in gut mucus is mucin 2 (MUC2) secreted by goblet cells. Fluctuations in MUC2 expression are considered a...
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Efficacy and safety of rebamipide liquid for chemoradiotherapy-induced oral mucositis in patients with head and neck cancer: a multicenter, randomized, double-blind, placebo-controlled, parallel-group phase II study
BackgroundRecent preclinical and phase I studies have reported that rebamipide decreased the severity of chemoradiotherapy-induced oral mucositis in...
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Oxidative Stress and Idiopathic Male Infertility
Idiopathic male infertility (IMI) refers to the condition where semen quality declines, but exact causatives are not identified. This occurs in...
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The potential curative effect of rebamipide in hepatic ischemia/reperfusion injury
Rebamipide (Reba), a gastroprotective drug, has signified its hepatoprotective activity; however, its possible post-therapeutic intervention in...
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Fabrication, in Vitro, and in Vivo Characterization of Mucoadhesive Berberine-Loaded Blended Wafers for Treatment of Chemotherapy-Induced Oral Mucositis
This study aims to design and characterize berberine-loaded wafers for the treatment of chemotherapy-induced oral mucositis. Wafers were prepared by...
