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Formulation of Saxagliptin Oral Films: Optimization, Physicochemical Characterization, In-Vivo Assessment, and In-Vitro Real-Time Release Monitoring via a Novel Polyaniline Nanoparticles-Based Solid-Contact Screen Printed Ion-Selective Electrode
Oral dispersible films have received broad interest due to fast drug absorption and no first-path metabolism, leading to high bioavailability and...
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Real-Time Particle Emission Monitoring for the Non-Invasive Prediction of Lung Deposition via a Dry Powder Inhaler
Although inhalation therapy represents a promising drug delivery route for the treatment of respiratory diseases, the real-time evaluation of lung...
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An Integrated Real-time Monitoring and Statistical Process Control Approach for Coating Process and Product Quality via In-line Optical Coherence Tomography
PurposeThe thickness and other quality aspects of pharmaceutical coatings can be significantly impacted by coating process conditions. Under certain...
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Development of Inline Near-Infrared Spectroscopy Method for Real-Time Monitoring of Blend Uniformity of Direct Compression and Granulation-Based Products at Commercial Scales
Blending is a critical intermediate unit operation for all solid oral formulations. For blend uniformity testing, API content in the blend must be...
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Diagnostic performance of mpox virus (MPXV) real-time PCR assays: multicenter assessment and extended sensitivity analysis
PurposeTo comprehensively investigate the diagnostic performance of routinely used assays in MPXV testing, the National Center of Clinical...
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CAR T-cell behavior and function revealed by real-time imaging
Adoptive transfer of T-cells expressing chimeric antigen receptors (CAR) has shown remarkable clinical efficacy against advanced B-cell malignancies....
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Drug Release from Surfactant-Containing Amorphous Solid Dispersions: Mechanism and Role of Surfactant in Release Enhancement
PurposeTo understand how surfactants affect drug release from ternary amorphous solid dispersions (ASDs), and to investigate different mechanisms of...
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Identification of Differentially Expressed Genes in Human Colorectal Cancer Using RNASeq Data Validated on the Molecular Level with Real-Time PCR
Colorectal cancer (CRC) is a prevalent cancer with high morbidity and mortality rates worldwide. Late diagnosis is a significant contributor to low...
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Detection of rat lungworm (Angiostrongylus cantonensis) infection by real-time PCR from the peripheral blood of animals: a preliminary study
Rat lungworm disease or neuroangiostrongyliasis is a cerebral parasitic infection that affects humans and animals alike. Its clinical signs and...
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Testing of Medical Devices
Medical device testing plays a vital role in ensuring the safety, efficacy, and quality of medical devices before they are introduced to the market....
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Development of In Vitro Dissolution Testing Methods to Simulate Fed Conditions for Immediate Release Solid Oral Dosage Forms
In vitro dissolution testing is widely used to mimic and predict in vivo performance of oral drug products in the gastrointestinal (GI) tract. This...
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Magnetic-bead-based DNA-capture-assisted real-time polymerase chain reaction and recombinase polymerase amplification for the detection of African swine fever virus
African swine fever (ASF) is a deadly disease in swine caused by African swine fever virus (ASFV). The global spread of ASFV has resulted in...
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Meeting report: Advancing accelerated regulatory review with Real-Time Oncology Review (RTOR), Project Orbis, and the Product Quality Assessment Aid
The American Association of Pharmaceutical Scientists (AAPS) Chemistry, Manufacturing, and Controls (CMC) Community hosted two virtual panel...
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Older adults are impaired in the release of grip force during a force tracking task
Age-related changes in force generation have been implicated in declines in older adult manual dexterity. While force generation is a critical aspect...
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Independent control of COVID-19 vaccines by EU Official Control Authority Batch Release: challenges, strengths and successes
Vaccines have been a key tool in stemming the tide of the COVID-19 pandemic. The rapid development of effective vaccines against COVID-19, together...
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Field testing a new ICD coding system: methods and early experiences with ICD-11 Beta Version 2018
ObjectiveA beta version (2018) of International Classification of Diseases, 11th Revision for MMS (ICD-11), needed testing. Field-testing involves...
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QBD Approach for Design and Characterization of Pramlintide Microspheres for Controlled Drug Release
PurposeThe research was centered on the optimization of the microsphere formulation through a systematic quality-by-design (QBD) methodology, as well...
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Development, Physicochemical Characteristics and Pharmacokinetics of a New Sustained-Release Bilayer Tablet Formulation of Tramadol with an Immediate-Release Component for Twice-Daily Administration
Background and ObjectiveThere are some potential concerns about the currently marketed solid oral dosage forms of tramadol, including decreased...
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Conventional vs Mechanistic IVIVC: A Comparative Study in Establishing Dissolution Safe Space for Extended Release Formulations
The use of in vitro - in vivo correlation (IVIVC) for extended release oral dosage forms is an important technique that can avoid potential clinical...
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Circulating tumor nucleic acids: biology, release mechanisms, and clinical relevance
BackgroundDespite advances in early detection and therapies, cancer is still one of the most common causes of death worldwide. Since each tumor is...
