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A robust walking detection algorithm using a single foot-worn inertial sensor: validation in real-life settings
Walking activity and gait parameters are considered among the most relevant mobility-related parameters. Currently, gait assessments have been mainly...
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Comparison of the 2022 and 2017 European LeukemiaNet risk classifications in a real-life cohort of the PETHEMA group
Next-Generation Sequencing is needed for the accurate genetic risk stratification of acute myeloid leukemia according to European LeukemiaNet (ELN)...
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Clinical outcome predictors for metastatic renal cell carcinoma: a retrospective multicenter real-life case series
Over the last decades, the therapeutic armamentarium of metastatic renal cell carcinoma (mRCC) has been revolutionized by the advent of...
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Exposure–Response Analyses of Olaparib in Real-Life Patients with Ovarian Cancer
BackgroundOlaparib is given in a fixed dose of twice-daily 300 mg in patients who are diagnosed with ovarian cancer, breast cancer, prostate cancer...
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Insights for clinical management from the real-life data of the centralized West of Scotland biliary cancer clinic
BackgroundWith the increasing of novel therapeutics for the treatment of Biliary Tract Cancers (BTC), and the need to assess their socio-economic...
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Real life data on nintedanib safety: idiopathic pulmonary fibrosis versus systemic sclerosis-interstitial lung disease and strategies adopted to manage adverse effects
ObjectiveNintedanib (NIN) is an antifibrotic drug approved to slow the progression of idiopathic pulmonary fibrosis (IPF) and systemic...
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How does the human brain process noisy speech in real life? Insights from the second-person neuroscience perspective
Comprehending speech with the existence of background noise is of great importance for human life. In the past decades, a large number of...
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Cardiovascular adverse events-related to GnRH agonists and GnRH antagonists: analysis of real-life data from Eudra-Vigilance and Food and Drug Administration databases entries
Introduction and objectivesGnRH agonists and GnRH antagonists are two of the mainstays of hormonal therapy (HT) for prostate cancer (PCa). These...
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Acute skin toxicity of conventional fractionated versus hypofractionated radiotherapy in breast cancer patients receiving regional node irradiation: the real-life prospective multicenter HYPOBREAST cohort
BackgroundLarge-scale trials have shown that hypofractionated adjuvant breast radiotherapy was as effective in terms of survival and local control as...
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Evaluation of quality of life in lung cancer patients receiving radiation and Viscum album L.: a real-world data study
BackgroundLung cancer (LC) is associated with high mortality and poor quality of life (QoL). The disease as well as oncological treatments such as...
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The impact of locoregional treatments for metastatic castration resistant prostate cancer on disease progression: real life experience from a multicenter cohort
BackgroundAvailable data on medical treatment of metastatic castration resistant prostate cancer (mCRPC) support the use of more than one therapy...
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Real-life experiences with CAR T-cell therapy with idecabtagene vicleucel (ide-cel) for triple-class exposed relapsed/refractory multiple myeloma patients
BackgroundChimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment landscape of relapsed/refractory multiple myeloma (RRMM),...
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Exposure–Response Analysis of Osimertinib in EGFR Mutation Positive Non-Small Cell Lung Cancer Patients in a Real-Life Setting
BackgroundOsimertinib, an irreversible inhibitor of the epidermal growth factor receptor (EGFR) is an important drug in the treatment of...
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Favorable safety profile of moderate hypofractionated over normofractionated radiotherapy in breast cancer patients: a multicentric prospective real-life data farming analysis
BackgroundModerately hypofractionated whole-breast radiotherapy (HFRT) has proven to be as safe and efficient as normofractionated radiotherapy...
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Monitoring of Adverse Events and Safety in Autoinflammatory Diseases: Real-Life Data from the Eurofever Registry
ObjectivesThe study is aimed to evaluate the impact of safety events in the Eurofever registry for Autoinflammatory diseases.
Methods ...
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Combination of mutations in genes controlling DNA repair and high mutational load plays a prognostic role in pancreatic ductal adenocarcinoma (PDAC): a retrospective real-life study in Sardinian population
BackgroundPatients with pancreatic ductal adenocarcinoma (PDCA) carrying impaired mismatch repair mechanisms seem to have an outcome advantage under...
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Intake of l-serine before bedtime prevents the delay of the circadian phase in real life
BackgroundIt has been shown in laboratory experiments using human subjects that ingestion of the non-essential amino acid l -serine before bedtime...
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Current perspectives in obesity management: unraveling the impact of different therapy approach in real life obesity care
BackgroundThe challenge of addressing obesity persists in healthcare, necessitating nuanced approaches and personalized strategies. This study aims...
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Evaluation of power wheelchair driving performance in simulator compared to driving in real-life situations: the SIMADAPT (simulator ADAPT) project—a pilot study
ObjectiveThe objective of this study was to evaluate users’ driving performances with a Power Wheelchair (PWC) driving simulator in comparison to the...
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Low- vs high-dose ARNI effects on clinical status, exercise performance and cardiac function in real-life HFrEF patients
PurposeOnly a few studies are available on dose-related effects of sacubitril/valsartan (angiotensin receptor neprilysin inhibition (ARNI)) in...
