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Revisiting reactive oxygen species production in hypoxia
Cellular responses to hypoxia are crucial in various physiological and pathophysiological contexts and have thus been extensively studied. This has...
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Role of Hypoxia and Reactive Oxygen Species in Cancer Biology
Cancer is a critical community health problem. In the future, it is foreseen that there will be more aged people with more diseases, especially...
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Correlation Between Reactive Oxygen Species and Synbiotics for Effective Treatment of Cancer
Reactive oxygen species (ROS) are groups or categories of reactive molecules evolving through significant signaling pathways. Since all normal cells...
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Reactive Oxygen Species in Male Reproductive Cancers
Reactive Oxygen Species (ROS) play a major role in reprogramming cells to cancerous phenotype. Cells have antioxidant protection mechanisms to cope...
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Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils
Inhibitory immune receptors set thresholds for immune cell activation, and their deficiency predisposes a person to autoimmune responses. However,...
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Pathological Role of Reactive Oxygen Species on Female Reproduction
Oxidative stress (OS), a clinical predicament characterized by a shift in homeostatic imbalance among prooxidant molecules embracing reactive oxygen...
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Free Radicals, Reactive Oxygen Species, and Their Biomarkers
Free radicals (FRs) and/or reactive oxygen species (ROS) are bioactive substances generated inevitably during the metabolic process of organisms. To...
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Targeting Reactive Oxygen Species (ROS) for Cancer Therapy
Reactive oxygen species (ROS) are the highly reactive molecules that play vital roles in cancer progression as well as in the regulation of important...
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Targeting Reactive Oxygen Species (ROS) for Cancer Therapy
Reactive oxygen species (ROS) are the highly reactive molecules that play vital roles in cancer progression as well as in the regulation of important...
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Reactive Oxygen Species: Central Regulators of the Tumor Microenvironment
Reactive oxygen species (ROS), a group of molecules generated by partial reduction of oxygen, have been postulated as central regulators of essential...
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Oxidative Stress: Reactive Chemical Intermediates
Oxidative stress is characterized by an imbalance between the production of reactive chemical intermediates and the ability of organisms to...
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Mitophagy and reactive oxygen species interplay in Parkinson’s disease
Mitophagy impairment and oxidative stress are cardinal pathological hallmarks in Parkinson’s disease (PD), a common age-related neurodegenerative...
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Reactive Oxygen Species in Stem Cell Proliferation and Cancer
Reactive oxygen species (ROS) are chemically reactive species derived from oxygen molecule and can easily react with a variety of other molecules...
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Reactive Oxygen Species–Mediated Cancer Progression and Metastasis
Reactive oxygen species (ROS) are involved in all stages of cancer and therefore their levels have a profound effect on the outcome of this disease....
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Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species (collectively known as ROS/RNS) is termed oxidative eustress...
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Pathological Roles of Reactive Oxygen Species in Male Reproduction
Reactive oxygen species (ROS) are free radicals that have at least one unpaired electron and play specific roles in the human body. An imbalance of...
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Promoting reactive oxygen species accumulation to overcome tyrosine kinase inhibitor resistance in cancer
BackgroundIn tumor treatment, protein tyrosine kinase inhibitors (TKIs) have been extensively utilized. However, the efficacy of TKI is significantly...
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Roles of neutrophil reactive oxygen species (ROS) generation in organ function impairment in sepsis
Sepsis is a condition of severe organ failure caused by the maladaptive response of the host to an infection. It is a severe complication affecting...
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Loss of the large conductance calcium-activated potassium channel causes an increase in mitochondrial reactive oxygen species in glioblastoma cells
Mitochondrial potassium (mitoK) channels play an important role in cellular physiology. These channels are expressed in healthy tissues and cancer...
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Reactive Oxygen Species–Induced Cancer Cell Death: A Therapeutic Approach
Reactive oxygen species (ROS) are molecules that contain oxygen, generated by metabolically active cells. Endogenous and exogenous factors play a...