Search
Search Results
-
In the new era of psychedelic assisted therapy: A systematic review of study methodology in randomized controlled trials
Recent years have seen a resurgence in randomized, placebo controlled trials (RCTs) utilizing non-classical psychedelics (e.g. 3,4-methyl enedioxy...
-
Assessing the steroid-sparing effect of biological agents in randomized controlled trials for lupus: a sco** review
Prompt disease control of flares in patients with systemic lupus erythematosus (SLE) is a priority in treatment strategy planning. However, the...
-
Efficacy and safety of high-frequency repetitive transcranial magnetic stimulation (rTMS) for migraine: a meta-analysis of randomized controlled trials
ObjectiveTo assess the efficacy and safety of high-frequency repetitive transcranial magnetic stimulation in the prevention or treatment of migraine...
-
Efficacy and safety of mesenchymal stem cells therapy in COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials
BackgroundThe coronavirus disease 2019 (COVID-19) has become a serious public health issue. In COVID-19 patients, the elevated levels of inflammatory...
-
Effect of different non-pharmacologic placebo treatments on migraine prevention: a network meta-analysis of randomized controlled trials
BackgroundPlacebo control plays an important role in evaluating the effectiveness of interventions. Specifying differential effects of various...
-
Systematic review of fatigue severity in ME/CFS patients: insights from randomized controlled trials
BackgroundMyalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating illness medically unexplained, affecting approximately 1% of...
-
Efficacy and Safety of Repetitive Transcranial Magnetic Stimulation in Spinocerebellar Ataxia Type 3: a Systematic Review and Meta‑analysis of Randomized Controlled Trials
Therapeutic alternatives for spinocerebellar ataxia type 3 (SCA3) are limited. Repetitive transcranial magnetic stimulation (rTMS) as a potential...
-
Acute Kidney Injury from Intravitreal Anti-vascular Endothelial Growth Factor Drugs: A Systematic Review and Meta-analysis of Randomized Controlled Trials
BackgroundSeveral observational studies have reported acute kidney injury from intravitreal anti-vascular endothelial growth factor (anti-VEGF) drugs...
-
Remimazolam versus propofol for sedation in gastrointestinal endoscopy and colonoscopy within elderly patients: a meta-analysis of randomized controlled trials
PurposePropofol has become the sedative of choice for endoscopy and colonoscopy. However, it has shown associations with various adverse effects,...
-
Non-invasive brain stimulation treatments for migraine prophylaxis: a network meta-analysis of randomized controlled trials
Background and objectivesMigraine is a major public health problem owing to its long disease duration and disease relapse. Non-invasive brain...
-
Fructose-induced FGF21 secretion does not activate brown adipose tissue in Japanese young men: randomized cross-over and randomized controlled trials
BackgroundHuman brown adipose tissue (BAT) activity is associated with lower body fatness and favorable glucose metabolism. Previous studies reported...
-
The effect of vitamin C on the risk of mortality in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials
Background and AimsVitamin C appears to be a viable treatment option for patients with COVID-19.
MethodsWe conducted a systematic review and...
-
Randomized Controlled Trials 1: Design
Today’s clinical practice relies on the application of well-designed clinical research, the gold standard test of an intervention being the...
-
Efficacy of cognitive behavioral therapy for insomnia in the perinatal period: a meta-analysis of randomized controlled trials
The meta-analysis aims to explore the effect of cognitive behavioral therapy for insomnia (CBT-I) in the perinatal period. Randomized controlled...
-
Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials
Prurigo nodularis (PN) is a chronic inflammatory skin disease with intensely pruritic nodules. The LIBERTY-PN PRIME and PRIME2 phase 3 trials...
-
Impact of combined propranolol and oxytocin on the process and outcomes of labor: a meta-analysis of randomized controlled trials
PurposeTo systematically review the impact of propranolol combined with oxytocin on the process and outcomes of labor.
MethodsA comprehensive...
-
Efficacy and safety of bempedoic acid lipid-lowering therapy: a systematic review and meta-analysis of randomized controlled trials
AimThis systematic review and meta-analysis was conducted to synthesize the efficacy and safety of bempedoic acid in patients requiring...
-
Effect of aspirin on incidence, recurrence, and mortality in prostate cancer patients: integrating evidence from randomized controlled trials and real-world studies
PurposeAspirin has been suggested to reduce the risk of cancer. However, previous studies have been inconsistent regarding the relationship between...
-
Effects of Pharmacological Intervention on Recovery After Sevoflurane Anesthesia in Children: a Network Meta-analysis of Randomized Controlled Trials
Sevoflurane, commonly administered to children as anesthesia, often leads to emergence delirium (ED). Currently, a consensus is lacking among...
-
Mindfulness interventions for craving reduction in substance use disorders and behavioral addictions: systematic review and meta-analysis of randomized controlled trials
BackgroundHigh-quality evidence is still required to affirm the efficacy of mindfulness-based interventions (MBIs) in craving reduction. MBIs may be...
