Search
Search Results
-
Distinct profiles of LRRK2 activation and Rab GTPase phosphorylation in clinical samples from different PD cohorts
Despite several advances in the field, pharmacodynamic outcome measures reflective of LRRK2 kinase activity in clinical biofluids remain urgently...
-
Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson’s disease and pharmacodynamic biomarkers
Expression or phosphorylation levels of leucine-rich repeat kinase 2 (LRRK2) and its Rab substrates have strong potential as disease or...
-
RAB7A GTPase Is Involved in Mitophagosome Formation and Autophagosome–Lysosome Fusion in N2a Cells Treated with the Prion Protein Fragment 106–126
Failed communication between mitochondria and lysosomes causes dysfunctional mitochondria, which may induce mitochondria-related neurodegenerative...
-
Differences in endosomal Rab gene expression between positive and negative COVID-19 patients
ObjectiveSARS CoV-2, the etiologic agent of coronavirus disease-2019 (COVID-19) is well-known to use ACE2 to begin internalization. Some viruses...
-
Homozygous variant in MADD, encoding a Rab guanine nucleotide exchange factor, results in pleiotropic effects and a multisystemic disorder
Rab proteins coordinate inter-organellar vesicle-mediated transport, facilitating intracellular communication, protein recycling, and signaling...
-
The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology
In Parkinson’s disease (PD) misfolded alpha-synuclein (aSyn) accumulates in the substantia nigra, where dopaminergic neurons are progressively lost....
-
Antiparasitic dibenzalacetone inhibits the GTPase activity of Rab6 protein of Leishmania donovani (LdRab6), a potential target for its antileishmanial effect
Visceral leishmaniasis (VL, also known as kala-azar) is a vector borne disease caused by obligate intracellular protozoan parasite Leishmania donovani ...
-
The Regulatory Mechanism of Rab21 in Human Diseases
Rab proteins are important components of small GTPases and play crucial roles in regulating intracellular transportation and cargo delivery....
-
Localization, traffic and function of Rab34 in adipocyte lipid and endocrine functions
BackgroundExcessive lipid accumulation in the adipose tissue in obesity alters the endocrine and energy storage functions of adipocytes. Adipocyte...
-
Trafficking in blood vessel development
Blood vessels demonstrate a multitude of complex signaling programs that work in concert to produce functional vasculature networks during...
-
Shc and the Control of Small GTPase Dynamics in Cellular Anchorage
Specialized metazoan cells have diverse functions which require them to interact differently with the body’s matrix scaffolds. Resident tissue cells,...
-
Regulation of Small GTPase Prenylation in the Nervous System
Mevalonate pathway inhibitors have been extensively studied for their roles in cholesterol depletion and for inhibiting the prenylation and...
-
Loss of TBC1D2B causes a progressive neurological disorder with gingival overgrowth
Biallelic loss-of-function variants in TBC1D2B have been reported in five subjects with cognitive impairment and seizures with or without gingival...
-
Rab37 mediates trafficking and membrane presentation of PD-1 to sustain T cell exhaustion in lung cancer
BackgroundProgrammed cell death protein 1 (PD-1) is an immune checkpoint receptor expressed on the surface of T cells. High expression of PD-1 leads...
-
The Fusion Between Autophagic Vesicles and Lysosomes
The autophagosome delivers engulfed substrates to the lysosome for degradation via membrane fusion between the autophagosome and the lysosome. The...
-
Recent advances in conventional and unconventional vesicular secretion pathways in the tumor microenvironment
All cells in the changing tumor microenvironment (TME) need a class of checkpoints to regulate the balance among exocytosis, endocytosis, recycling...
-
Systematic rare variant analyses identify RAB32 as a susceptibility gene for familial Parkinson’s disease
Despite substantial progress, causal variants are identified only for a minority of familial Parkinson’s disease (PD) cases, leaving high-risk...
-
Transcriptomic and metabolomic analyses reveal the essential nature of Rab1B in Toxoplasma gondii
BackgroundThe protozoan parasite Toxoplasma gondii encodes a dozen Rab proteins, which are parts of the small GTPase superfamily and regulate...
-
SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression
BackgroundPancreatic ductal adenocarcinoma (PDAC) is expected to soon surpass colorectal cancer as a leading cause of cancer mortality in both males...
-
Enterovirus-A71 exploits RAB11 to recruit chaperones for virus morphogenesis
BackgroundEnterovirus 71 (EV-A71) causes Hand, Foot and Mouth Disease (HFMD) in children and has been associated with neurological complications. The...
