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Evidence for existence of insulin-like factor 3 (INSL3) hormone-receptor system in the ovarian corpus luteum and extra-ovarian reproductive organs during pregnancy in goats
Insulin-like factor 3 (INSL3), initially described as a male hormone, is expressed in female reproductive organs during the estrous cycle and...
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Writing Research Protocols in Pharmacological Studies
The effects of drugs or chemicals are studied at every plausible level of complexity involving pure proteins, cells in tissue culture, intact...
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Optical genome map** identifies clinically relevant genomic rearrangements in prostate cancer biopsy sample
BackgroundProstate cancer (PCa) is characterized by complex genomic rearrangements such as the ETS oncogene family fusions, yet the clinical...
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Functional Neuroanatomy of Relaxin-3/RXFP3 Systems in the Brain: Implications for Integrated Neuroendocrine and Behavioural Control
Neuropeptides play key neuromodulatory roles in the mammalian central nervous system. Relaxin-3, a neuropeptide discovered by homology searching of...
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Understanding the genetic complexity of puberty timing across the allele frequency spectrum
Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women,...
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Evolutionary Changes in Pathways and Networks of Genes Expressed in the Brains of Humans and Macaques
As the key organ that separates humans from nonhuman primates, the brain has continuously evolved to adapt to environmental and climatic changes....
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Substances for regenerative wound healing during antler renewal stimulated scar-less restoration of rat cutaneous wounds
Scarification is the outcome of cutaneous wound healing under normal conditions. Although considerable effort has been expended in this field,...
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The Molecular Basis of Sex Determination and Differentiation: Implications for Understanding DSD
DSD are a heterogeneous group of congenital conditions in which development of chromosomal, gonadal or anatomical sex is atypical. They are complex...
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Systems genetics analysis identifies calcium-signaling defects as novel cause of congenital heart disease
BackgroundCongenital heart disease (CHD) occurs in almost 1% of newborn children and is considered a multifactorial disorder. CHD may segregate in...
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Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication...
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Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals
Modern living challenges female reproductive health. We are witnessing a rise in reproductive disorders and drop in birth rates across the world. The...
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Hormone Relaxin as Biomarker for Bone Health and Disease
Bone homeostasis is maintained by fine-tuning of the dynamic balance between bone resorption via osteoclasts and bone formation via osteoblasts. Bone...
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