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RNAi-based drug design: considerations and future directions
More than 25 years after its discovery, the post-transcriptional gene regulation mechanism termed RNAi is now transforming pharmaceutical...
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Oral delivery of RNAi for cancer therapy
Cancer is a major health concern worldwide and is still in a continuous surge of seeking for effective treatments. Since the discovery of RNAi and...
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RNAi: The Mosquito Defense System Against Damage Due to Arbovirus Infection
Although I have been engaged with arboviruses and their mosquito vectors for over 50 years, the fascinating research I describe in this chapter has...
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Targeting SOD1 via RNAi with PEGylated graphene oxide nanoparticles in platinum-resistant ovarian cancer
Acquired platinum resistance poses a significant therapeutic impediment to ovarian cancer patient care, accounting for more than 200,000 deaths...
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RNA Interference (RNAi) in Tomato Crop Research
RNA interference (RNAi) is a posttranscriptional gene silencing phenomenon induced by double-stranded RNA. It has been widely used as a knockdown...
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Toxicity after AAV delivery of RNAi expression constructs into nonhuman primate brain
RNA interference (RNAi) for spinocerebellar ataxia type 1 can prevent and reverse behavioral deficits and neuropathological readouts in mouse models,...
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Development of an RNAi-based microalgal larvicide for the control of Aedes aegypti
BackgroundMosquito-borne diseases affect over half of the human population globally. Multiple studies have shown that chemical insecticides are...
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RNAi-mediated CHS-2 silencing affects the synthesis of chitin and the formation of the peritrophic membrane in the midgut of Aedes albopictus larvae
BackgroundMosquitoes are an important vector of viral transmission, and due to the complexity of the pathogens they transmit, vector control may be...
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Interaction of Mesonivirus and Negevirus with arboviruses and the RNAi response in Culex tarsalis-derived cells
BackgroundMosquito-specific viruses (MSVs) comprise a variety of different virus families, some of which are known to interfere with infections of...
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RNAi gene knockdown in the poultry red mite, Dermanyssus gallinae (De Geer 1778), a tool for functional genomics
BackgroundThe avian haematophagous ectoparasite Dermanyssus gallinae , commonly known as the poultry red mite, causes significant economic losses to...
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Gene editing and RNAi approaches for COVID-19 diagnostics and therapeutics
The novel coronavirus pneumonia (COVID-19) is a highly infectious acute respiratory disease caused by Severe Acute Respiratory Syndrome-Related...
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Development of an AAV9-RNAi-mediated silencing strategy to abrogate TRPM4 expression in the adult heart
The cation channel transient receptor potential melastatin 4 (TRPM4) is a calcium-activated non-selective cation channel and acts in cardiomyocytes...
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RNAi and chemogenetic reporter co-regulation in primate striatal interneurons
Using genetic tools to study the functional roles of molecularly specified neuronal populations in the primate brain is challenging, primarily...
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RNA Interference in Experimental Animal Models: Its Application in Cancer Research and Therapy
Cancer, is a major health problem in the world, that has to be faced with new technologies and methods. Chemotherapy is still being widely used...
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RNA Interference in Experimental Animal Models: Its Application in Cancer Research and Therapy
Cancer, is a major health problem in the world, that has to be faced with new technologies and methods. Chemotherapy is still being widely used...
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P4 protein of an Indian isolate of rice tungro bacilliform virus modulates gene silencing
Plant hosts and their viral pathogens are engaged in a constant cycle of defense and counter-defense as part of a molecular arms race, principal...
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Gene silencing in the aedine cell lines C6/36 and U4.4 using long double-stranded RNA
BackgroundRNA interference (RNAi) is a target-specific gene silencing method that can be used to determine gene functions and investigate...
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Use of RNA Interference Technology for Improving Economically Valuable Traits of Cereal Crops
AbstractRNA interference (RNAi) is a new potential tool for plant breeding by introducing small noncoding RNA sequences with the possibility of...
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Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges
RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles extending beyond its...
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Role of muscle FOXO gene in exercise against the skeletal muscle and cardiac age-related defects and mortality caused by high-salt intake in Drosophila
FOXO has long been associated with aging, exercise, and tissue homeostasis, but it remains unclear what the role is of the muscle FOXO gene in E...
