Search
Search Results
-
Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats
Myotonic dystrophy type 1 (DM1) is an RNA-dominant disease whose pathogenesis stems from the functional loss of muscleblind-like RNA-binding proteins...
-
RNA Interference Ex Vivo
RNA interference (RNAi) is a widely used technique to regulate the expression of genes and proteins with a high degree of specificity that is not...
-
Fortilin as a Biomarker in Toxicity
Fortilin, the multifunctional protein, also known as translationally controlled tumor protein (TCTP), presents in most eukaryotic organisms. It is...
-
Behavioural Effects and RNA-seq Analysis of Aβ42-Mediated Toxicity in a Drosophila Alzheimer’s Disease Model
Alzheimer’s disease (AD) is the most common neurological ailment worldwide. Its process comprises the unique aggregation of extracellular senile...
-
Emerging role of RNA modification and long noncoding RNA interaction in cancer
RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the occurrence and progression...
-
The Role of RNA-Binding Proteins in Cancers
RNA-binding proteins (RBPs) play fundamental roles in most aspects of cell regulation, specifically in post-transcriptional modifications, thanks to...
-
Integrated mRNA- and miRNA-sequencing analyses unveil the underlying mechanism of tobacco pollutant-induced developmental toxicity in zebrafish embryos
Tobacco pollutants are prevalent in the environment, leading to inadvertent exposure of pregnant females. Studies of these pollutants' toxic effects...
-
Strategies to reduce the risks of mRNA drug and vaccine toxicity
mRNA formulated with lipid nanoparticles is a transformative technology that has enabled the rapid development and administration of billions of...
-
RNA Nanomedicine: Delivery Strategies and Applications
Delivery of RNA using nanomaterials has emerged as a new modality to expand therapeutic applications in biomedical research. However, the delivery of...
-
Nrf2-mediated ferroptosis of spermatogenic cells involved in male reproductive toxicity induced by polystyrene nanoplastics in mice
Microplastics (MPs) and nanoplastics (NPs) have become hazardous materials due to the massive amount of plastic waste and disposable masks, but their...
-
Frameworks for transformational breakthroughs in RNA-based medicines
RNA has sparked a revolution in modern medicine, with the potential to transform the way we treat diseases. Recent regulatory approvals, hundreds of...
-
RNA-dependent RNA polymerase (RdRp) natural antiviral inhibitors: a review
Viral diseases are the cause of many global epidemics, leading to deaths, affecting the quality of life of populations, and impairing public health....
-
Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity
Identifying genetic modifiers of familial amyotrophic lateral sclerosis (ALS) may reveal targets for therapeutic modulation with potential...
-
Messenger RNA Nanovaccine in Cancer Immunotherapy
During the past 2 years, messenger RNA (mRNA) nanovaccine has shown its remarkable antiviral efficacy, rapid manufacture, and good safety profile for...
-
Toxicology and Toxicity Studies of Nano-Biomaterials
The subject of nanotechnology has significant changes in the last 10 years as new applications of nanoparticles (NPs) and other nano-biomaterials...
-
Amyloid Beta–Mediated Neurovascular Toxicity in Alzheimer’s Disease
The brain vascular system receives one-fifth of the total oxygen from the cardiac output, and this transport system is highly dependent on...
-
Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity
Anti-tuberculosis (AT) medications, including isoniazid (INH), can cause drug-induced liver injury (DILI), but the underlying mechanism remains...
-
Amplifying gene expression with RNA-targeted therapeutics
Many diseases are caused by insufficient expression of mutated genes and would benefit from increased expression of the corresponding protein....
-
Ceria nanoparticles: biomedical applications and toxicity
Ceria nanoparticles (CeO 2 NPs) have become popular materials in biomedical and industrial fields due to their potential applications in...
-
Toxicity evaluation of silica nanoparticles for delivery applications
Silica nanoparticles (SiNPs) are being explored as nanocarriers for therapeutics delivery, which can address a number of intrinsic drawbacks of...
