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CircSKA3 is Associated With the Risk of Extracranial Artery Stenosis and Plaque Instability Among Ischemic Stroke Patients
Circular RNA circSKA3 (spindle and kinetochore-related complex subunit 3) has been identified as a prognostic factor in ischemic stroke. The...
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Characterization of genomic instability-related genes predicts survival and therapeutic response in lung adenocarcinoma
BackgroundLung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer (NSCLC) and is the leading cause of cancer death...
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Genome instability-related long non-coding RNA in clear renal cell carcinoma determined using computational biology
BackgroundThere is evidence that long non-coding RNA (lncRNA) is related to genetic stability. However, the complex biological functions of these...
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Genetic and Chromosomal Instability
All tumours have genetic or chromosomal abnormalities or both, and most cancers are diseases of ageing, suggesting the progressive accumulation of...
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cGAS-STING pathway expression correlates with genomic instability and immune cell infiltration in breast cancer
Genomic instability, as caused by oncogene-induced replication stress, can lead to the activation of inflammatory signaling, involving the cGAS-STING...
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Production and Testing of RNA Origami Anticoagulants
Nucleic acid nanotechnology provides the ability to create unprecedented nanostructures with diverse architectures and functions that can be utilized...
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The Role of RNA-Binding Proteins in Cancers
RNA-binding proteins (RBPs) play fundamental roles in most aspects of cell regulation, specifically in post-transcriptional modifications, thanks to...
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Gene Expression in Synovium of Rotator Cuff Tear Patients Determined by RNA Sequencing
Rotator cuff tear (RCT) is a common shoulder disorder related to pain and dysfunction. However, the pathological mechanism of RCT remains unclear....
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Investigation of ENO2 as a promising novel marker for the progression of colorectal cancer with microsatellite instability-high
BackgroundMicrosatellite instability-high (MSI-H) has emerged as a significant biological characteristic of colorectal cancer (CRC). Studies reported...
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Systematic discovery of gene fusions in pediatric cancer by integrating RNA-seq and WGS
BackgroundGene fusions are important cancer drivers in pediatric cancer and their accurate detection is essential for diagnosis and treatment....
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Sustained inactivation of the Polycomb PRC1 complex induces DNA repair defects and genomic instability in epigenetic tumors
Cancer initiation and progression are typically associated with the accumulation of driver mutations and genomic instability. However, recent studies...
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Genetic Instability and Cancer
Cancer cells have a high degree of genomic plasticity, a characteristic that endows them with the dangerous ability to adapt to new environmental...
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RNA modifications in cancer
Currently, more than 170 modifications have been identified on RNA. Among these RNA modifications, various methylations account for two-thirds of...
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Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges
RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles extending beyond its...
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Potentials as biomarker and therapeutic target of upregulated long non-coding RNA HLA-F antisense RNA 1 in hepatitis B virus-associated hepatocellular carcinoma
The tissue-specific characteristics have encouraged researchers to identify organ-specific lncRNAs as disease biomarkers. This study aimed to...
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Downregulation of RNA binding protein 47 predicts low survival in patients and promotes the development of renal cell malignancies through RNA stability modification
RNA binding proteins (RBPs) are crucial for cell function, tissue growth, and disease development in disease or normal physiological processes. RNA...
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Biological roles of the RNA m6A modification and its implications in cancer
The N 6 -Methyladenosine (m 6 A) modification of RNA transcripts is the most prevalent and abundant internal modification in eukaryotic messenger RNAs...
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The new world of RNA diagnostics and therapeutics
The 5th Workshop IRE on Translational Oncology was held in Rome (Italy) on 27–28 March at the IRCCS Regina Elena National Cancer Institute. This...
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The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability
BackgroundTP53, the most frequently mutated gene in human cancers, orchestrates a complex transcriptional program crucial for cancer prevention....
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In silico identification, characterization, and expression analysis of RNA recognition motif (RRM) containing RNA-binding proteins in Aedes aegypti
RNA-binding proteins (RBPs) are the proteins that bind RNAs and regulate their functioning. RBPs in mosquitoes are gaining attention due to their...
