Search
Search Results
-
RNA processing modification mediated subtypes illustrate the distinctive features of tumor microenvironment in hepatocellular carcinoma
Multiple transcript isoforms of genes can be formed by processing and modifying the 5′ and 3′ ends of RNA. Herein, the aim of this study is to...
-
Regulatory roles of N6-methyladenosine (m6A) methylation in RNA processing and non-communicable diseases
Post-transcriptional RNA modification is an emerging epigenetic control mechanism in cells that is important in many different cellular and...
-
Knockdown of ribosome RNA processing protein 15 suppresses migration of hepatocellular carcinoma through inhibiting PATZ1-associated LAMC2/FAK pathway
BackgroundRibosomal RNA processing protein 15 (RRP15) has been found to regulate the progression of hepatocellular carcinoma (HCC). Nevertheless, the...
-
Decoding protein–RNA interactions using CLIP-based methodologies
Protein–RNA interactions are central to all RNA processing events, with pivotal roles in the regulation of gene expression and cellular functions....
-
RNA modifications in cancer
Currently, more than 170 modifications have been identified on RNA. Among these RNA modifications, various methylations account for two-thirds of...
-
Emerging role of RNA modification and long noncoding RNA interaction in cancer
RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the occurrence and progression...
-
Epi-Drugs Targeting RNA Dynamics in Cancer
From the early discovery of ribonucleic acid in 1868, the RNA world has seen constant evolution. To date, more than ten types of RNA species are...
-
Investigating Mitochondrial Transcriptomes and RNA Processing Using Circular RNA Sequencing
Transcriptomic technologies have revolutionized the study of gene expression and RNA biology. Different RNA sequencing methods enable the analyses of...
-
RNA-binding proteins and exoribonucleases modulating miRNA in cancer: the enemy within
Recent progress in the investigation of microRNA (miRNA) biogenesis and the miRNA processing machinery has revealed previously unknown roles of...
-
RNA Metabolism Governs Immune Function and Response
Inflammation is a complex process that protects our body from various insults such as infection, injury, and stress. Proper inflammation is...
-
The Role of RNA-Binding Proteins in Cancers
RNA-binding proteins (RBPs) play fundamental roles in most aspects of cell regulation, specifically in post-transcriptional modifications, thanks to...
-
Detection of Hepatitis A RNA, Hepatitis E RNA, Human Adenovirus F DNA, and Norovirus RNA in Fresh and Frozen Berry Products at Point of Retail in Ireland
Soft fruits are at particular risk of contamination with enteric viruses such as Hepatitis A virus (HAV), Hepatitis E Virus (HEV), Norovirus (NoV),...
-
RNA-Binding Proteins: A Role in Neurotoxicity?
Despite sustained efforts to treat neurodegenerative diseases, little is known at the molecular level to understand and generate novel therapeutic...
-
The nexus between RNA-binding proteins and their effectors
RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA molecule, from its production to its destruction. Whereas much...
-
Infection of Fetal Membranes with Mycobacterium tuberculosis and Tissue Processing to Isolate RNA for Expression Analysis
This chapter outlines the methodology employed to infect the chorionic and amniotic membranes with Mycobacterium tuberculosis during pregnancy....
-
Exosomal RNA Sequencing from Body Fluid Samples
Exosomes are microcapsules released by different types of cells. It contains DNA, RNA, proteins, and other substances. Exosomes spread in body...
-
RNA Editing with CRISPR/Cas13
CRISPR/Cas system has emerged as a powerful tool for precise genome editing with numerous applications such as knockout, knock-in, base editing,...
-
Big data and deep learning for RNA biology
The exponential growth of big data in RNA biology (RB) has led to the development of deep learning (DL) models that have driven crucial discoveries....
-
RNA modifications in physiology and disease: towards clinical applications
The ability of chemical modifications of single nucleotides to alter the electrostatic charge, hydrophobic surface and base pairing of RNA molecules...
-
RNA modification: mechanisms and therapeutic targets
RNA modifications are dynamic and reversible chemical modifications on substrate RNA that are regulated by specific modifying enzymes. They play...
