Search
Search Results
-
Risk assessment of aflatoxin B1 in herbal medicines and plant food supplements marketed in Malaysia using margin of exposure and RISK21 approaches
Aflatoxin B 1 (AFB 1 ) is a mycotoxin produced by several species of Aspergillus fungi which can cause liver cancer in animals and humans. This study...
-
Waist circumference and risk of Parkinson’s disease
Although many studies support the association of obesity with neurodegenerative diseases, such as Parkinson’s disease (PD), there are limited data...
-
Opinion: regulatory genotoxicity: past, present and future
I will reflect on the role of genotoxicity in the regulation of chemical safety, summarizing the past and current situation, and giving personal...
-
Among classic myeloproliferative neoplasms, essential thrombocythemia is associated with the greatest risk of venous thromboembolism during COVID-19
In a multicenter European retrospective study including 162 patients with COVID-19 occurring in essential thrombocythemia (ET, n = 48), polycythemia...
-
Stress and cancer: mechanisms, significance and future directions
The notion that stress and cancer are interlinked has dominated lay discourse for decades. More recent animal studies indicate that stress can...
-
Analysis of a cohort of 279 patients with hairy-cell leukemia (HCL): 10 years of follow-up
In total, 279 patients with hairy-cell leukemia (HCL) were analyzed, with a median follow-up of 10 years. Data were collected up to June 2018. We...
-
A framework for chemical safety assessment incorporating new approach methodologies within REACH
The long-term investment in new approach methodologies (NAMs) within the EU and other parts of the world is beginning to result in an emerging...
-
Genomics in neurodevelopmental disorders: an avenue to personalized medicine
Despite the remarkable number of scientific breakthroughs of the last 100 years, the treatment of neurodevelopmental disorders (e.g., autism spectrum...
-
Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes
Heterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct...
-
Toxicity testing in the 21st century: progress in the past decade and future perspectives
Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing based on expanded application of high-throughput in...
-
The road to precision psychiatry: translating genetics into disease mechanisms
Hundreds of genetic loci increasing risk for neuropsychiatric disorders have recently been identified. This success, perhaps paradoxically, has posed...
-
Evolution of multi-parametric MRI quantitative parameters following transrectal ultrasound-guided biopsy of the prostate
Background:To determine the evolution of prostatic multi-parametric magnetic resonance imaging (mp-MRI) signal following transrectal ultrasound...
-
Regulatory science - JEMS symposium in 2014
The Public Symposium of the Japanese Environmental Mutagen Society (JEMS), entitled “Regulatory Science”, was held at the Shiba-Kyoritsu campus of...
-
A subset of genetic susceptibility variants for colorectal cancer also has prognostic value
We investigated the possible influence of 86 single-nucleotide polymorphisms (SNPs), known to associate with the risk of colorectal cancer (CRC), on...
-
Primary-care providers’ perceived barriers to integration of genetics services: a systematic review of the literature
Purpose:We aimed to systematically review the literature to identify primary-care providers’ perceived barriers against provision of genetics...
-
Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk
To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692...
-
Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion
Insulin secretion has a crucial role in glucose homeostasis, and failure to secrete sufficient insulin is a hallmark of type 2 diabetes. Genome-wide...
-
From expression QTLs to personalized transcriptomics
Approaches that combine expression quantitative trait loci (eQTLs) and genome-wide association (GWA) studies are offering new functional information...
-
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
Metformin is the most commonly used pharmacological therapy for type 2 diabetes. We report a genome-wide association study for glycemic response to...
