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Novel neutralizing SARS-CoV-2-specific mAbs offer detection of RBD linear epitopes
BackgroundTo stop the spread of the COVID-19 disease, it is crucial to create molecular tools to investigate and diagnose COVID-19. Current efforts...
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Delivery of Experimental mRNA Vaccine Encoding the RBD of SARS-CoV-2 by Jet Injection
We studied a needle-free jet injection delivery of an experimental mRNA vaccine encoding the receptor-binding domain of the SARS-CoV-2 S protein...
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Antibody Fc-binding profiles and ACE2 affinity to SARS-CoV-2 RBD variants
Emerging SARS-CoV-2 variants, notably Omicron, continue to remain a formidable challenge to worldwide public health. The SARS-CoV-2 receptor-binding...
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Enhanced protective efficacy of a thermostable RBD-S2 vaccine formulation against SARS-CoV-2 and its variants
With the rapid emergence of variants of concern (VOC), the efficacy of currently licensed vaccines has reduced drastically. VOC mutations largely...
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Immunogenicity phase II study evaluating booster capacity of nonadjuvanted AKS-452 SARS-Cov-2 RBD Fc vaccine
AKS-452, a subunit vaccine comprising an Fc fusion of the ancestral wild-type (WT) SARS-CoV-2 virus spike protein receptor binding domain (SP/RBD),...
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Enhancement of NETosis by ACE2-cross-reactive anti-SARS-CoV-2 RBD antibodies in patients with COVID-19
BackgroundHigh levels of neutrophil extracellular trap (NET) formation or NETosis and autoantibodies are related to poor prognosis and disease...
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Computational analysis of affinity dynamics between the variants of SARS-CoV-2 spike protein (RBD) and human ACE-2 receptor
The novel coronavirus SARS-CoV-2 resulted in a significant worldwide health emergency known as the COVID-19 pandemic. This crisis has been marked by...
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α-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation
Rapid eye movement (REM) sleep behavior disorder (RBD) is a powerful early sign of Parkinson’s disease (PD), but the pathogenetic mechanism involved...
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Activation and induction of antigen-specific T follicular helper cells play a critical role in recombinant SARS-CoV-2 RBD vaccine-induced humoral responses
The role of follicular T helper (Tfh) cells in humoral response has been considered essential in recent years. Understanding how Tfh cells control...
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Modulating the immune response to SARS-CoV-2 by different nanocarriers delivering an mRNA expressing trimeric RBD of the spike protein: COVARNA Consortium
Vaccines based on mRNA technology have revolutionized the field. In fact, lipid nanoparticles (LNP) formulated with mRNA are the preferential vaccine...
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Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice
Development of SARS-CoV-2 vaccines that protect vulnerable populations is a public health priority. Here, we took a systematic and iterative approach...
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RBD and hyposmia in Moroccan patients with a synucleinopathy: prevalence and the timing of occurrence in a large cohort
IntroductionRapid Eye Movement Sleep Behavior Disorder (RBD) and hyposmia are common in synucleinopathies and they tend to occur in connection to the...
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A triple-RBD-based mucosal vaccine provides broad protection against SARS-CoV-2 variants of concern
The rapid mutation and spread of SARS-CoV-2 variants urge the development of effective mucosal vaccines to provide broad-spectrum protection against...
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A comparative blind study between skin biopsy and seed amplification assay to disclose pathological α-synuclein in RBD
To compare the diagnostic accuracy of the immunofluorescence (IF) technique and aSyn-seed amplification assay (aSyn-SAA) of skin and cerebrospinal...
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Safety and immunogenicity of a recombinant protein RBD fusion heterodimer vaccine against SARS-CoV-2
In response to COVID-19 pandemic, we have launched a vaccine development program against SARS-CoV-2. Here we report the safety, tolerability, and...
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Brain atrophy pattern in de novo Parkinson’s disease with probable RBD associated with cognitive impairment
Rapid eye movement sleep behavior disorder (RBD) is associated with high likelihood of prodromal Parkinson’s disease (PD) and is common in de novo...
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Discrimination of SARS-CoV-2 omicron variant and its lineages by rapid detection of immune-escape mutations in spike protein RBD using asymmetric PCR-based melting curve analysis
BackgroundThe SARS-CoV-2 Omicron strain has multiple immune-escape mutations in the spike protein receptor-binding domain (RBD). Rapid detection of...
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Scientific rationale for develo** potent RBD-based vaccines targeting COVID-19
Vaccination of the global population against COVID-19 is a great scientific, logistical, and moral challenge. Despite the rapid development and...
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Sequential immunization with SARS-CoV-2 RBD vaccine induces potent and broad neutralization against variants in mice
The current COVID-19 pandemic caused by constantly emerging SARS-CoV-2 variants still poses a threat to public health worldwide. Effective...
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Comprehensive map** of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants
BackgroundThe receptor-binding domain (RBD) variants of SARS-CoV-2 could impair antibody-mediated neutralization of the virus by host immunity; thus,...
