Search
Search Results
-
A patient with multiple primary malignant neoplasms with high variant allele frequencies of RB1, TP53, and TERT
Multiple primary malignant neoplasms are a rare disease with tumors of different histology or morphology arising in various sites. Next-generation...
-
Targeting the untargetable: RB1-deficient tumours are vulnerable to Skp2 ubiquitin ligase inhibition
Proteins that regulate the cell cycle are accumulated and degraded in a coordinated manner during the transition from one cell cycle phase to the...
-
RB1 screening of retinoblastoma patients in Sri Lanka using targeted next generation sequencing (NGS) and gene ratio analysis copy enumeration PCR (GRACE-PCR)
BackgroundRetinoblastoma (RB) a tumour affecting those under 5 years, has a prevalence of 1 in 20,000, with around twenty new diagnoses per year in...
-
Involvement of Autophagy in the Protective Effects of Ginsenoside Rb1 in a Rat Model of Traumatic Brain Injury
Background and ObjectivesNo treatment modalities have been identified to prevent neuron damage induced by traumatic brain injury (TBI). The objective...
-
Inhibition of high level E2F in a RB1 proficient MYCN overexpressing chicken retinoblastoma model normalizes neoplastic behaviour
PurposeRetinoblastoma, a childhood cancer, is most frequently caused by bi-allelic inactivation of RB1 gene. However, other oncogenic mutations such...
-
Retinoblastoma patient-derived stem cells—an in vivo model to study the role of RB1 in adipogenesis
Retinoblastoma (RB1) protein is a multifunctional protein that plays an important role in cell cycle regulation and cell differentiation, including...
-
Ginsenoside Rb1 alleviates diabetic kidney podocyte injury by inhibiting aldose reductase activity
Panax notoginseng , a traditional Chinese medicine, exerts beneficial effect on diabetic kidney disease (DKD), but its mechanism is not well...
-
Co-expression and prognosis analyses of GLUT1–4 and RB1 in breast cancer
BackgroundCurrent treatment methods for patients with triple-negative breast cancer (TNBC) are very limited, and the prognosis of TNBC is relatively...
-
RNF2 mediates pulmonary fibroblasts activation and proliferation by regulating mTOR and p16-CDK4-Rb1 signaling pathway
BackgroundPulmonary fibrosis (PF) is a chronic, progressive interstitial lung disease with unknown etiology, associated with increasing morbidity and...
-
A Japanese case of castration-resistant prostate cancer with BRCA2 and RB1 co-loss and TP53 mutation: a case report
BackgroundAbnormalities in homologous recombination contribute to the aggressive nature of castration-resistant prostate cancer. Retinoblastoma...
-
Analysis of the Frequency of 10 Polymorphic Markers of CDKN2A and RB1 Genes in Russian Populations
The study of population frequencies of rare clinically significant alleles is a prerequisite of the development of personalized medicine. We...
-
RB1 and TP53 co-mutations correlate strongly with genomic biomarkers of response to immunity checkpoint inhibitors in urothelial bladder cancer
BackgroundMuscle invasive urothelial bladder carcinoma (MIBC) present RB1 and TP53 somatic alterations in a variable percentage of tumors throughout...
-
IDH-wild type glioblastomas featuring at least 30% giant cells are characterized by frequent RB1 and NF1 alterations and hypermutation
Giant cell glioblastoma (GC-GBM) is a rare variant of IDH -wt GBM histologically characterized by the presence of numerous multinucleated giant cells...
-
Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma
Retinoblastoma is a childhood cancer of the retina involving germline or somatic alterations of the RB Transcriptional Corepressor 1 gene, RB1 . Rare...
-
Tumorsuppressorgene
Tumorsuppressorgene sind die zweite wichtige Klasse von Krebsgenen. Im Gegensatz zu Onkogenen müssen Tumorsuppressorgene in ihrer Funktion...
-
A first case of ductal adenocarcinoma of the prostate having characteristics of neuroendocrine phenotype with PTEN, RB1 and TP53 alterations
BackgroundDuctal adenocarcinoma and neuroendocrine cancer are rare subtypes of prostate cancer with poor prognosis and limited therapeutic options....
-
Differential impact of tumor suppressor gene (TP53, PTEN, RB1) alterations and treatment outcomes in metastatic, hormone-sensitive prostate cancer
BackgroundAltered tumor suppressor genes (TSG-alt) in prostate cancer are associated with worse outcomes. The prognostic value of TSG-alt in...
-
Ginsenoside Rb1 induces a pro-neurogenic microglial phenotype via PPARγ activation in male mice exposed to chronic mild stress
BackgroundAnti-inflammatory approaches are emerging as a new strategy for the treatment of depressive disorders. Ginsenoside Rb1 (GRb1), a major...
-
Tumor Suppressor Genes
Tumor suppressors are the second major type of cancer genes. In contrast to oncogenes, tumor suppressor genes have to undergo loss of function to...