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Evaluating the comprehensive diagnosis efficiency of lung cancer, including measurement of SHOX2 and RASSF1A gene methylation
Methylation of the promoters of SHOX2 and RASSF1A (LungMe®) exhibits promise as a potential molecular biomarker for diagnosing lung cancer. This...
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Association of the SHOX2 and RASSF1A methylation levels with the pathological evolution of early-stage lung adenocarcinoma
Background The methylation of SHOX2 and RASSF1A shows promise as a potential biomarker for the early screening of lung cancer, offering a solution to...
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Identification of RASSF1A promoter hypermethylation as a biomarker for hepatocellular carcinoma
BackgroundRAS association domain family protein 1A ( RASSF1A ) promoter hypermethylation is suggested to be linked to hepatocellular carcinoma (HCC),...
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Investigation of the relationship between CTLA4 and the tumor suppressor RASSF1A and the possible mediating role of STAT4 in a cohort of Egyptian patients infected with hepatitis C virus with and without hepatocellular carcinoma
The Ras association domain family 1 isoform A ( RASSF1A ), cytotoxic T lymphocyte antigen 4 ( CTLA-4 ), and signal transducer and activator of...
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Aberrant hydroxymethylation in promoter CpG regions of genes related to the cell cycle and apoptosis characterizes advanced chronic myeloid leukemia disease, poor imatinib respondents and poor survival
BackgroundThere is strong evidence that disease progression, drug response and overall clinical outcomes of CML disease are not only decided by...
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Hypermethylation of Gene Promoters in Blood Leukocytes of Irradiated Individuals—Final Research Results
AbstractHypermethylation of CpG islands in the promoter regions of four genes ( p53 , ATM , SOD3 , ESR1 ) was studied in blood leukocytes of irradiated...
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Early diagnosis of ovarian cancer based on methylation profiles in peripheral blood cell-free DNA: a systematic review
Patients diagnosed with epithelial ovarian cancer (OC) have a 5-year survival rate of 49%. For early-stage disease, the 5-year survival rate is above...
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High-risk HPV infection-associated hypermethylated genes in oropharyngeal squamous cell carcinomas
BackgroundHPV-positive oropharyngeal squamous cell carcinomas (OPSCCs) are sensitive to chemo-radiation therapy and have favorable survival outcomes...
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NDR2 kinase contributes to cell invasion and cytokinesis defects induced by the inactivation of RASSF1A tumor-suppressor gene in lung cancer cells
BackgroundRASSF1A, a tumor suppressor gene, is frequently inactivated in lung cancer leading to a YAP-dependent epithelial-mesenchymal transition...
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Role of MST1 in the regulation of autophagy and mitophagy: implications for aging-related diseases
As a key mechanism to maintain cellular homeostasis under stress conditions, autophagy/mitophagy is related to the occurrence of metabolic disorders,...
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The CpG island methylator phenotype increases the risk of high-grade squamous intraepithelial lesions and cervical cancer
BackgroundHigh-risk human papillomavirus (HR-HPV) infection is the main cause of cervical cancer, but additional alterations are necessary for its...
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Gene Methylation in Circulating Cell-Free DNA from the Blood Plasma as Prognostic and Predictive Factor in Breast Cancer
AbstractDespite considerable progress in the early-stage diagnostics and treatment of breast cancer (BC), there is a high chance of recurrence. The...
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Immunohistochemical Profile of Tumor Suppressor Proteins RASSF1A and LATS1/2 in Relation to p73 and YAP Expression, of Human Inflammatory Bowel Disease and Normal Intestine
The intestinal neoplastic transformation is a possible risk of chronic inflammatory bowel disease (IBD). Previous evidence in mice IBD provides a...
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Urine DNA biomarkers for hepatocellular carcinoma screening
BackgroundHepatocellular carcinoma (HCC) occurs in a well-defined high-risk patient population, but better screening tests are needed to improve...
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Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis
BackgroundUpregulation of the mitogen-activated protein kinase (MAPK) cascade is common in hepatocellular carcinoma (HCC). Neuroblastoma RAS viral...
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Nierenzellkarzinome
Dieses Kapitel stellt die molekularen Mechanismen in einigen der vielen verschiedenen Tumorarten heraus, die in der erwachsenen Niere entstehen....
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Diagnosing and monitoring pancreatic cancer through cell-free DNA methylation: progress and prospects
Pancreatic cancer is one of the most challenging cancers due to its high mortality rates. Considering the late diagnosis and the limited survival...
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Liquid biopsies based on DNA methylation as biomarkers for the detection and prognosis of lung cancer
Lung cancer (LC) is the main cause of cancer-related mortality. Most LC patients are diagnosed in an advanced stage when the symptoms are obvious,...
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Liquid Biopsy in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the most deadly neoplasms with a poor prognosis. Due to the significant tumor heterogeneity of HCC,...
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Molecular Pathogenesis of Lung Cancer: Evolving Landscapes Based on Past Experience
Lung cancers are characterized by abundant genetic diversity with relatively few recurrent mutations occurring at high frequency. However, genetic...