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Unraveling the Intricacies of OPG/RANKL/RANK Biology and Its Implications in Neurological Disorders—A Comprehensive Literature Review
The OPG/RANKL/RANK framework, along with its specific receptors, plays a crucial role in bone remodeling and the functioning of the central nervous...
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Ensemble methods of rank-based trees for single sample classification with gene expression profiles
Building Single Sample Predictors (SSPs) from gene expression profiles presents challenges, notably due to the lack of calibration across diverse...
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Cross-platform comparison of immune signatures in immunotherapy-treated patients with advanced melanoma using a rank-based scoring approach
BackgroundGene expression profiling is increasingly being utilised as a diagnostic, prognostic and predictive tool for managing cancer patients....
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Hormone and receptor activator of NF-κB (RANK) pathway gene expression in plasma and mammographic breast density in postmenopausal women
BackgroundHormones impact breast tissue proliferation. Studies investigating the associations of circulating hormone levels with mammographic breast...
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In Vitro Testing of Sunscreens for Dermal Absorption: Method Comparison and Rank Order Correlation with In Vivo Absorption
Evaluating the dermal absorption of sunscreen UV filters requires the development of a bio-predictable in vitro permeation test (IVPT). This work...
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Rank-invariant estimation of inbreeding coefficients
The two alleles an individual carries at a locus are identical by descent (ibd) if they have descended from a single ancestral allele in a reference...
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Joint low-rank prior and difference of Gaussian filter for magnetic resonance image denoising
The low-rank matrix approximation (LRMA) is an efficient image denoising method to reduce additive Gaussian noise. However, the existing low-rank...
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Rank-preserving biclustering algorithm: a case study on miRNA breast cancer
Effective biomarkers aid in the early diagnosis and monitoring of breast cancer and thus play an important role in the treatment of patients...
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Dynamic brain effective connectivity analysis based on low-rank canonical polyadic decomposition: application to epilepsy
In this paper, a new method to track brain effective connectivity networks in the context of epilepsy is proposed. It relies on the combination of...
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RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer
BackgroundAround 15–20% of primary breast cancers are characterized by HER2 protein overexpression and/or HER2 gene amplification. Despite the...
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Association Between Serum Selenium Concentration and OPG/RANKL/RANK Axis in Patients with Arterial Hypertension
The aim of the study was to determine the relationship between the serum selenium concentration (Se–S) and the blood concentrations of...
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Lipopolysaccharide- TLR-4 Axis regulates Osteoclastogenesis independent of RANKL/RANK signaling
BackgroundLipopolysaccharide (LPS) is an endotoxin and a vital component of gram-negative bacteria’s outer membrane. During gram-negative bacterial...
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Sharp decrease in the Laplacian matrix rank of phase-space graphs: a potential biomarker in epilepsy
In this paper, phase space reconstruction from stereo-electroencephalography data of ten patients with focal epilepsy forms a series of graphs....
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A novel index of functional connectivity: phase lag based on Wilcoxon signed rank test
Phase synchronization has been an effective measurement of functional connectivity, detecting similar dynamics over time among distinct brain...
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Motion correction and noise removing in lung diffusion-weighted MRI using low-rank decomposition
Lung diffusion-weighted magnetic resonance imaging (DWI) has shown a promising value in lung lesion detection, diagnosis, differentiation, and...
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IL-15 deficiency alleviates steroid-induced osteonecrosis of the femoral head by impact osteoclasts via RANKL-RANK-OPG system
BackgroundWhether IL-15 is involved in the development of steroid-induced osteonecrosis of the femoral head (ONFH) is investigated.
Methods ...
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Polymorphisms within the RANK and RANKL Encoding Genes in Patients with Rheumatoid Arthritis: Association with Disease Progression and Effectiveness of the Biological Treatment
Inconsistency of the results regarding the genetic variability within genes coding for receptor activator of nuclear factor κB (RANK) and its ligand...
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The Non-Bone-Related Role of RANK/RANKL Signaling in Cancer
RANK ligand (RANKL) is a member of the tumor necrosis factor alpha superfamily of cytokines. It is the only known ligand binding to a membrane...
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Combining RANK/RANKL and ERBB-2 targeting as a novel strategy in ERBB-2-positive breast carcinomas
BackgroundERBB-2 is overexpressed in about 20% of breast cancers (BCs), indicating poor prognosis. The receptor activator of nuclear factor-κB (RANK)...
