Search
Search Results
-
RAD51 and Infertility: A Review and Case-Control Study
RAD51 is a highly conserved recombinase involved in the strand invasion/exchange of double-stranded DNA by homologous single-stranded DNA during...
-
Bleomycin induces senescence and repression of DNA repair via downregulation of Rad51
BackgroundBleomycin, a potent antitumor agent, is limited in clinical use due to the potential for fatal pulmonary toxicity. The accelerated DNA...
-
RAD51 is a poor prognostic marker and a potential therapeutic target for oral squamous cell carcinoma
ObjectivesRAD51 overexpression has been reported to serve as a marker of poor prognosis in several cancer types. This study aimed to survey the role...
-
In Silico design and characterization of RAD51 protein inhibitors targeting homologous recombination repair for cancer therapy
Cancer occurs when a portion of the body's cells begin to divide uncontrollably and spread into surrounding tissues. Most common reason for growth is...
-
CircCDYL2 bolsters radiotherapy resistance in nasopharyngeal carcinoma by promoting RAD51 translation initiation for enhanced homologous recombination repair
BackgroundRadiation therapy stands to be one of the primary approaches in the clinical treatment of malignant tumors. Nasopharyngeal Carcinoma, a...
-
Racial differences in RAD51 expression are regulated by miRNA-214-5P and its inhibition synergizes with olaparib in triple-negative breast cancer
BackgroundTriple-negative breast cancer (TNBC) affects young women and is the most aggressive subtype of breast cancer (BC). TNBCs disproportionally...
-
2-Hydroxy-3-methylanthraquinone inhibits homologous recombination repair in osteosarcoma through the MYC-CHK1-RAD51 axis
BackgroundOsteosarcoma is a malignant bone tumor that usually affects adolescents aged 15–19 y. The DNA damage response (DDR) is significantly...
-
Basal expression of RAD51 foci predicts olaparib response in patient-derived ovarian cancer xenografts
BackgroundThe search for biomarkers to evaluate ovarian cancer (OC) homologous recombination (HR) function and predict the response to therapy is an...
-
Elp1 facilitates RAD51-mediated homologous recombination repair via translational regulation
BackgroundRAD51-dependent homologous recombination (HR) is one of the most important pathways for repairing DNA double-strand breaks (DSBs), and its...
-
Predictive value of RAD51 on the survival and drug responsiveness of ovarian cancer
BackgroundOvarian cancer has greatly endangered and deteriorated female health conditions worldwide. Refinement of predictive biomarkers could enable...
-
Terpenoids-enriched fraction of Celastrus orbiculatus sensitizes gemcitabine by disrupting Chk1/RAD51-mediated DNA damage response in pancreatic cancer
The stem of Celastrus orbiculatus , a traditional Chinese herbal medicine exhibits prominent anti-inflammatory and anti-tumor activities. In the...
-
Pattern of RAD51-G135C Polymorphism among Eastern Mediterranean Turkish Population and Association with Breast Cancer
AbstractThe RAD51 gene encodes proteins that are important for the repair of double-strand DNA breaks by recombination. Thus, genetic variability in...
-
DNA Strand Exchange to Monitor Human RAD51-Mediated Strand Invasion and Pairing
The homologous recombination (HR) pathway maintains genomic integrity by repairing DNA double-strand breaks (DSBs), single-strand DNA gaps, and...
-
HDAC inhibitor ITF2357 reduces resistance of mutant-KRAS non-small cell lung cancer to pemetrexed through a HDAC2/miR-130a-3p-dependent mechanism
BackgroundHistone deacetylases (HDAC) contribute to oncogenic program, pointing to their inhibitors as a potential strategy against cancers. We,...
-
Mechanisms of Oncogenesis
Carcinogenesis can be due to replication errors, faulty repair of damaged DNA, and exposure to DNA-damaging agents. The two major carcinogenesis...
-
RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer
BackgroundThe DNA damage and repair pathway is considered a promising target for develo** strategies against cancer. RAD51, also known as RECA, is...
-
Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress
BackgroundMutations in genes associated with homologous recombination (HR) increase an individual’s risk of develo** triple-negative breast cancer...
-
Increased double-strand breaks in aged mouse male germ cells may result from changed expression of the genes essential for homologous recombination or nonhomologous end joining repair
DNA double-strand breaks (DSBs) are commonly appearing deleterious DNA damages, which progressively increase in male germ cells during biological...
