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Substantial Basis for Glyco-Assembly: Siglec7 and Synthetic Sialylpolymers
Sialic acid is one of the tags that are recognized as “self,” when immune cells survey “non-self” items using the sialic acid-recognizing lectins,...
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Time trends in survival and causes of death in multiple myeloma: a population-based study from Germany
BackgroundSteady evolution of therapies has improved prognosis of patients with multiple myeloma (MM) over the past two decades. Yet, knowledge about...
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Structure–Function Relationship of Channelrhodopsins
Ion-translocating rhodopsins, especially channelrhodopsins (ChRs), have attracted broad attention as a powerful tool to modulate the membrane...
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Engineering PD-1-targeted small protein variants for in vitro diagnostics and in vivo PET imaging
BackgroundProgrammed cell death 1 (PD-1) belongs to immune checkpoint proteins ensuring negative regulation of the immune response. In non-small cell...
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Assessing immunogenicity barriers of the HIV-1 envelope trimer
Understanding the balance between epitope shielding and accessibility on HIV-1 envelope (Env) trimers is essential to guide immunogen selection for...
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Sex-dimorphic neuroprotective effect of CD163 in an α-synuclein mouse model of Parkinson’s disease
Alpha-synuclein (α-syn) aggregation and immune activation represent hallmark pathological events in Parkinson’s disease (PD). The PD-associated...
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Silencing of DsbA-L gene impairs the PPARγ agonist function of improving insulin resistance in a high-glucose cell model
Disulfide-bond A oxidoreductase-like protein (DsbA-L) is a molecular chaperone involved in the multimerization of adiponectin. Recent studies have...
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Hyaluronic acid derivative-modified nano-structured lipid carrier for cancer targeting and therapy
To reduce the problems of poor solubility, high in vivo dosage requirement, and weak targeting ability of paclitaxel (PTX), a hyaluronic...
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Multi-biomarker strategy for prediction of myocardial dysfunction and mortality in sepsis
ObjectiveThe present study was to evaluate the feasibility of using the multi-biomarker strategy for the prediction of sepsis-induced myocardial...
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Horizontal transfer of a retrotransposon between parasitic nematodes and the common shrew
BackgroundAs the genomes of more metazoan species are sequenced, reports of horizontal transposon transfers (HTT) have increased. Our understanding...
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Neuronal brain-region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability
Epigenetic modifications confer stable transcriptional patterns in the brain, and both normal and abnormal brain function involve specialized brain...
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Identification and localization of Tospovirus genus-wide conserved residues in 3D models of the nucleocapsid and the silencing suppressor proteins
BackgroundTospoviruses (genus Tospovirus , family Peribunyaviridae , order Bunyavirales ) cause significant losses to a wide range of agronomic and...
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Characterization of major histocompatibility complex-related molecule 1 sequence variants in non-human primates
The major histocompatibility complex (MHC) class I-related molecule, MR1, presents vitamin B metabolites from bacteria and yeast to...
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Genomic features of bacterial adaptation to plants
Plants intimately associate with diverse bacteria. Plant-associated bacteria have ostensibly evolved genes that enable them to adapt to...
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Mutations in SLC5A6 associated with brain, immune, bone, and intestinal dysfunction in a young child
The human sodium-dependent multivitamin transporter (hSMVT) is a product of the SLC5A6 gene and mediates biotin, pantothenic acid, and lipoate uptake...
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The RNA-binding properties and domain of Rice stripe virus nucleocapsid protein
The nucleocapsid protein (NP) of rice stripe virus (RSV) encapsidates viral genomic RNAs to form virion. The binding of NP with RNA is essential for...
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Impact of clinical awareness and diagnostic tests on the underdiagnosis of Clostridium difficile infection
A multicenter study of Clostridium difficile infection (CDI) performed during 2008 in Spain revealed that two of every three episodes went...
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Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab
IntroductionImmunotherapy targeting amyloid-β peptide is under active clinical investigation for treatment of Alzheimer’s disease (AD). Among the...
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Design, synthesis, molecular docking, and biological evaluation of N-methyl-3-nitro-4-(nitromethyl)-4H-chromen-2-amine derivatives as potential anti-cancer agents
A series of N -methyl-3-nitro-4-(nitromethyl)-4 H -chromen-2-amine derivatives 8 were synthesized from 2-(( E )-2-nitrovinyl)phenol 7 and (( E )- N -methyl)-1-...
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Protein Hypercitrullination in CNS Demyelinating Disease Reversed by PAD Inhibition
Protein deimination (the conversion of peptide-bound arginine residues to citrulline) is a posttranslational modification which has important...