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L’invecchiamento e il sistema endocrino
Some of the changes occurring during aging have frequently been related to insufficient levels of one or more hormones. It is important to...
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A synthetic toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen
It has been proposed that activation of Toll-like receptors (TLRs) plays crucial roles in the polarization of adaptive immune responses. A synthetic...
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Integration of Genomics and Proteomics in Dissecting p53 Signaling
The discovery of the human genome and subsequent expansion of proteomics research combined with emerging technologies such as sophisticated...
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Modulation of p53 transcriptional activity by PRIMA-1 and Pifithrin-α on staurosporine-induced apoptosis of wild-type and mutated p53 epithelial cells
We recently argued for a major role of p53 in staurosporine(ST)-induced apoptosis of immortalized epithelial cells, depending on their p53 status....
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Chemosensory Inputs and Neural Remodeling in Carotid Body and Brainstem Catecholaminergic Cells
Exposure to hypoxia elicits an immediate increase in ventilation in order to face the tissue oxygen deficit. The acute response to hypoxia develops...
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Participation of Corticosteroids and Effects of Indomethacin on the Acute Inflammatory Response of Rats Fed n-6 or n-3 Polyunsaturated Fatty Acid-Rich Diets
We have previously shown that both n-3 (fish oil) and n-6 (soybean oil) PUFA-rich diets reduce carrageenan-induced paw edema in rats. The present...
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Blood-Brain Barrier and Blood-CSF Barrier in Metal-Induced Neurotoxicities
For a metal to enter the brain, it must pass the brain-barrier systems that safeguard brain chemical stability. These barriers exist both at the...
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On the relationship between the dopamine transporter and the reinforcing effects of local anesthetics in rhesus monkeys: practical and theoretical concerns
Rationale: Drugs that are self-administered appear to vary in their potency and effectiveness as positive reinforcers. Understanding mechanisms that...
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Extracellular glutamate increases in rostral ventrolateral medulla during static muscle contraction
The ventrolateral medulla is an important site involved in increases in arterial pressure and heart rate during static muscle contraction....
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Delivery of Metals to Brain and the Role of the Blood-Brain Barrier
Metals serve critical roles in brain as essential cofactors, catalysts, second messengers, and modulators of gene, enzyme, and receptor activity....
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Prediction of uptake of methyl mercury by rat erythrocytes using a two-compartment model
The uptake of methyl mercury (MeHg) by isolated rat erythrocytes was studied at 37°C using MeHg-cysteine (MeHgCySH), MeHg-glutathione (MeHgGSH),...
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Arterial diameter during central volume depletion in humans
The luminal diameter of the radial artery was followed by high frequency ultrasound during 50° head-up tilt-induced central volume depletion in ten...
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A laser Raman spectroscopic study on the interaction of alkylmercury with thiol and sulfur-containing compounds
The interaction of the methylmercury cation with sulfur compounds in aqueous solution at physiological pH was studied by laser Raman spectroscopy....
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Mercury Toxicity
Methyl, mercuric, and elemental mercury are the major chemical forms of mercury present in the environment and widely recognized as highly toxic...
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Membrane Transporters as Sites of Action and Routes of Entry for Toxic Metals
There is a long history of interest in the interaction of toxic metals with membranes for two reasons. First, it was recognized early on that plasma...
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Hypoxic Birds: Temperature and Respiration
The extreme cold at high altitudes compounds the hypoxic challenge that resident animals must meet. A bird called the alpine chough (Pyrrhocorax...