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Immunodetection of Pyruvate Carboxylase Expression in Human Astrocytomas, Glioblastomas, Oligodendrogliomas, and Meningiomas
Pyruvate carboxylase (PC) is an enzyme catalyzing the carboxylation of pyruvate to oxaloacetate. The enzymatic generation of oxaloacetate, an...
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Anemoside B4, a new pyruvate carboxylase inhibitor, alleviates colitis by reprogramming macrophage function
ObjectivesColitis is a global disease usually accompanied by intestinal epithelial damage and intestinal inflammation, and an increasing number of...
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Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression
BackgroundMetabolic plasticity mediates breast cancer survival, growth, and immune evasion during metastasis. However, how tumor cell metabolism is...
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Assessing Pyruvate Carboxylase Flux as a Mechanistic Biological Marker in Fasting
Pyruvate carboxylase (PC) is an enzyme that catalyzes pyruvate carboxylation for the formation of a tricarboxylic acid (TCA) cycle intermediate,...
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Assessing Pyruvate Carboxylase Flux as a Mechanistic Biological Marker in Fasting
Pyruvate carboxylase (PC) is an enzyme that catalyzes pyruvate carboxylation for the formation of a tricarboxylic acid (TCA) cycle intermediate,...
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Long noncoding RNA RP11-241J12.3 targeting pyruvate carboxylase promotes hepatocellular carcinoma aggressiveness by disrupting pyruvate metabolism and the DNA mismatch repair system
Accumulating evidence indicates that hepatitis B virus X protein (HBx) plays a key role in HBV-related hepatocellular carcinoma (HCC) aggressiveness;...
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The Long Noncoding RNA Gall Bladder Cancer-Associated Suppressor of Pyruvate Carboxylase Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer Cells and Induces Their Apoptosis
This study aimed to determine the role of the long noncoding RNA (lncRNA) gall bladder cancer-associated suppressor of pyruvate carboxylase (SOD2-1)...
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Pyruvate carboxylase and cancer progression
Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to...
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Modulation of Pyruvate Export and Extracellular Pyruvate Concentration in Primary Astrocyte Cultures
Astrocyte-derived pyruvate is considered to have neuroprotective functions. In order to investigate the processes that are involved in astrocytic...
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Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis
BackgroundPyruvate carboxylase (PC) is an important anaplerotic enzyme in the tricarboxylic acid cycle (TCA) in cancer cells. Although PC...
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Consumption and Metabolism of Extracellular Pyruvate by Cultured Rat Brain Astrocytes
Brain astrocytes are considered as glycolytic cell type, but these cells also produce ATP via mitochondrial oxidative phosphorylation. Exposure of...
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Ferrous sulfate reverses cerebral metabolic abnormality induced by minimal hepatic encephalopathy
Orally administered ferrous iron was previously reported to significantly improve the cognition and locomotion of patients with minimal hepatic...
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Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells
BackgroundAerobic glycolysis, discovered by Otto Warburg, is a hallmark of cancer metabolism even though not yet fully understood. The low activity...
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Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells
BackgroundPancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with limited treatment options. Pyruvate kinase, especially the M2 isoform...
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Crucial Metabolic Networks: Cancer Progression
The study of metabolic networks in cancer cells is essential for understanding the fundamental properties of living systems and how metabolic...
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Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer
BackgroundGlutamine serves as an important nutrient with many cancer types displaying glutamine dependence. Following cellular uptake glutamine is...
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Crucial Metabolic Networks: Cancer Progression
The study of metabolic networks in cancer cells is essential for understanding the fundamental properties of living systems and how metabolic...
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Two Metabolic Fuels, Glucose and Lactate, Differentially Modulate Exocytotic Glutamate Release from Cultured Astrocytes
Astrocytes have a prominent role in metabolic homeostasis of the brain and can signal to adjacent neurons by releasing glutamate via a...
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Generation of Human Pyruvate Carboxylase Knockout Cell Lines Using Retrovirus Expressing Short Hairpin RNA and CRISPR-Cas9 as Models to Study Its Metabolic Role in Cancer Research
We report two protocols to generate human pyruvate carboxylase knockdown and knockout cell lines using short hairpin RNA (shRNA) and CRISPR-Cas9...
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Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer
BackgroundOvercoming systemic dormancy and initiating secondary tumor grow under unique microenvironmental conditions is a major rate-limiting step...
