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Impact of acute dynamic exercise and arterial shear rate modification on radial artery low-flow mediated constriction in young men
PurposeLeg cycling exercise acutely augments radial artery low-flow mediated constriction (L-FMC). Herein, we sought to determine whether this is...
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Pulmonary Vasoreactivity
Pulmonary circulation is characterized by low intravascular arterial pressure and low vascular resistance. As compared with those of systemic...
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Purinergic regulation of pulmonary vascular tone
Purinergic signaling is a crucial determinant in the regulation of pulmonary vascular physiology and presents a promising avenue for addressing lung...
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Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats
BackgroundExposure to micro- and nanoplastic particles (MNPs) in humans is being identified in both the indoor and outdoor environment. Detection of...
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Farnesyl diphosphate synthase regulated endothelial proliferation and autophagy during rat pulmonary arterial hypertension induced by monocrotaline
BackgroundThe proliferation ability and autophagy level of pulmonary artery endothelial cells (PAECs) play an important role in promoting the...
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Pulmonary Microcirculation during Experimental Pulmonary Thromboembolism under Conditions of Activation and Blockade of Muscarinic Acetylcholine Receptors
Changes in pulmonary microcirculation were studied in isolated perfused rabbit lungs during modelling pulmonary thromboembolism under conditions of...
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Role of β3-Adrenoceptor Activation in Changes of Pulmonary Microhemodynamics after Experimental Pulmonary Thromboembolism
Changes in pulmonary microhemodynamics during modelling of pulmonary thromboembolism against the background of nebivolol and mirabegron pretreatment...
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SIRT 1 Activator Loaded Inhaled Antiangiogenic Liposomal Formulation Development for Pulmonary Hypertension
Pulmonary hypertension (PH) is characterized by the rise in mean pulmonary arterial pressure (≥ 20 mmHg at rest) due to the narrowing of the...
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PHD2 deletion in endothelial or arterial smooth muscle cells reveals vascular cell type-specific responses in pulmonary hypertension and fibrosis
Hypoxia plays an important regulatory role in the vasculature to adjust blood flow to meet metabolic requirements. At the level of gene...
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Contribution of Carotid Bodies on Pulmonary Function During Normoxia and Acute Hypoxia
Carotid bodies (CBs) are main peripheral chemoreceptors involved in breathing regulation. Despite the well-known role played by CBs on breathing...
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Obstructive sleep apnea-increased DEC1 regulates systemic inflammation and oxidative stress that promotes development of pulmonary arterial hypertension
Obstructive sleep apnea (OSA), characterized by chronic intermittent hypoxia (CIH), is a common risk factor for pulmonary arterial hypertension...
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Maternal paracetamol intake and fetal ductus arteriosus constriction/closure: comprehensive signal evaluation using the Austin Bradford Hill criteria
PurposeAcetaminophen (APAP) is available over-the-counter and widely regarded as safe for use in pregnancy. APAP has been used to close a...
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Cytokines, Chemokines, and Inflammation in Pulmonary Arterial Hypertension
According to the World Symposium Pulmonary Hypertension (WSPH) classification, pulmonary hypertension (PH) is classified into five categories based...
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Modeling of Hypervolemia in Pulmonary Circulation in Rats Changes the Structure of NO-Mediated Relaxation of Pulmonary Arteries
We analyzed the contribution of soluble guanylate cyclase-dependent pathway into NO-mediated relaxation of pulmonary arteries under conditions of...
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Medicinal Plants Used in the Treatment of Pulmonary Hypertension
Pulmonary hypertension is caused by a rise in the vascular tone thus affecting the structural composition of the pulmonary arteries. There are...
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Redox Regulation, Oxidative Stress, and Inflammation in Group 3 Pulmonary Hypertension
Group 3 pulmonary hypertension (PH), which occurs secondary to hypoxia lung diseases, is one of the most common causes of PH worldwide and has a high...
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Biomechanics in Small Artery Remodeling
In this chapter, we discuss how biomechanical forces influence vascular design. We will focus on the small arteries and arterioles, i.e., those...
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Targeting Carbonic Anhydrases in Cardiovascular and Pulmonary Disease
Carbonic anhydraseCarbonic anhydrase (CA) is present within many cells of the heartHeart, lungsLung, and the vasculatureVasculature. An understanding...
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Overview on Interactive Role of Inflammation, Reactive Oxygen Species, and Calcium Signaling in Asthma, COPD, and Pulmonary Hypertension
Inflammatory signaling is a major component in the development and progression of many lung diseases, including asthma, chronic obstructive pulmonary...
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The 10th International Conference on cGMP 2022: recent trends in cGMP research and development—meeting report
Increasing cGMP is a unique therapeutic principle, and drugs inhibiting cGMP-degrading enzymes or stimulating cGMP production are approved for the...
