Search
Search Results
-
-
Distinct concentration-dependent oxidative stress profiles by cadmium in a rat kidney proximal tubule cell line
Levels and chemical species of reactive oxygen/nitrogen species (ROS/RNS) determine oxidative eustress and distress. Abundance of uptake pathways and...
-
Is there a molecular basis for solvent drag in the renal proximal tubule?
The concept of solvent drag, i.e., water and solutes sharing the same pore and their transport being frictionally coupled, was first proposed in the...
-
Metabolic impact of genetic and chemical ADP/ATP carrier inhibition in renal proximal tubule epithelial cells
Mitochondrial dysfunction is pivotal in drug-induced acute kidney injury (AKI), but the underlying mechanisms remain largely unknown. Transport...
-
KCNE1 does not shift TMEM16A from a Ca2+ dependent to a voltage dependent Cl- channel and is not expressed in renal proximal tubule
The TMEM16A (ANO1) Cl - channel is activated by Ca 2+ in a voltage-dependent manner. It is broadly expressed and was shown to be also present in renal...
-
The (pro)renin receptor (ATP6ap2) facilitates receptor-mediated endocytosis and lysosomal function in the renal proximal tubule
The ATP6ap2 (Pro)renin receptor protein associates with H + -ATPases which regulate organellar, cellular, and systemic acid–base homeostasis. In the...
-
-
Nephrotoxic antisense oligonucleotide SPC5001 induces kidney injury biomarkers in a proximal tubule-on-a-chip
Antisense oligonucleotides (ASOs) are a promising therapeutic modality. However, failure to predict acute kidney injury induced by SPC5001 ASO...
-
-
Metabolic mechanisms of acute proximal tubular injury
Damage to the proximal tubule (PT) is the most frequent cause of acute kidney injury (AKI) in humans. Diagnostic and treatment options for AKI are...
-
High CD133 expression in proximal tubular cells in diabetic kidney disease: good or bad?
BackgroundProximal tubular cells (PTCs) play a critical role in the progression of diabetic kidney disease (DKD). As one of important progenitor...
-
Unveiling the hidden AP-1: revealing the crucial role of AP-1 in ccRCC at single-cell resolution
Clear cell renal cell carcinoma (ccRCC), as the most common histological subtype of kidney cancer, has been reported to originate primarily from...
-
The renal antioxidative effect of losartan involves heat shock protein 70 in proximal tubule cells
Angiotensin II exerts a cardinal role in the pathogenesis of hypertension and renal injury via action of angiotensin II type 1 (AT 1 ) receptors. Local...
-
HK-2 cell response to TGF-β highly depends on cell culture medium formulations
The immortalized human renal proximal tubular epithelial cell line HK-2 is most commonly used to study renal cell physiology and human kidney...
-
Functional Characterization of a Novel SLC4A4 Variant and Uniparental Isodisomy in Proximal Renal Tubular Acidosis Patient
SLC4A4 variants are the etiologies of inherited proximal renal tubular acidosis (pRTA), which results in metabolic acidosis, hypokalemia, glaucoma,...
-
Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids
Isolation of tissue-specific fetal stem cells and derivation of primary organoids is limited to samples obtained from termination of pregnancies,...
-
Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions
BackgroundDespite therapeutic advances, once a cancer has metastasized to the bone, it represents a highly morbid and lethal disease. One third of...
-
Microbiota and metabolites alterations in proximal and distal gastric cancer patients
BackgroundGlobally, gastric cancer is the third most common cancer and the third leading cause of cancer death. Proximal and distal gastric cancers...
-
Transport of NaCl, Organic Solutes, and Water in the Renal Tubule
The magnitude of renal function in humans is exemplified in Table 4.1. Solutes like sodium, chloride, and bicarbonate are reabsorbed above 99%. With...