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How calorie restriction slows aging: an epigenetic perspective
Genomic instability and epigenetic alterations are some of the prominent factors affecting aging. Age-related heterochromatin loss and decreased...
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Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor
Human immunodeficiency virus (HIV) and other lentiviruses adapt to new hosts by evolving to evade host-specific innate immune proteins that differ in...
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HIV-1 restriction by SERINC5
Serine incorporator 5 (SERINC5 or SER5) is a multipass transmembrane protein with ill-defined cellular activities. SER5 was recently described as a...
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Effects of endurance training under calorie restriction on energy substrate metabolism in mouse skeletal muscle and liver
We investigated whether calorie restriction (CR) enhances metabolic adaptations to endurance training (ET). Ten-week-old male Institute of Cancer...
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Impaired influenza A virus replication by the host restriction factor SAMHD1 which inhibited by PA-mediated dephosphorylation of the host transcription factor IRF3
BackgroundInfluenza A virus (IAV) can cause severe and life-threatening illness in humans and animals. Therefore, it is important to search for host...
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Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells
BackgroundSAMHD1 is a deoxynucleotide triphosphohydrolase that restricts replication of HIV-1 in differentiated leucocytes. HIV-1 is not restricted...
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N-Glycan Insertion for Probing Protein–Protein Interactions and Epitope Map**
Introducing an N-linked glycosylation motif into recombinant proteins at specific sites is a useful tool in probing protein–protein interactions and...
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Epigenetics Beyond Fetal Growth Restriction: A Comprehensive Overview
Fetal growth restriction is a pathological condition occurring when the fetus does not reach the genetically determined growth potential. The...
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Caloric restriction and metformin selectively improved LKB1-mutated NSCLC tumor response to chemo- and chemo-immunotherapy
BackgroundAbout 10% of NSCLCs are mutated in KRAS and impaired in STK11/LKB1 , a genetic background associated with poor prognosis, caused by an...
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Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy
Transarterial chemoembolization (TACE) is the first-line treatment for unresectable intermediate-stage hepatocellular carcinoma (HCC). It is of high...
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Indicators of LPO and Antioxidant Protection in Rats During Long-Term Restriction of Motor Activity
This article presents a comprehensive study of the parameters of LPO (concentrations of malondialdehyde, diene conjugates, and intensity of...
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Sex differences in response to obesity and caloric restriction on cognition and hippocampal measures of autophagic-lysosomal transcripts and signaling pathways
BackgroundObesity rates in the U.S. continue to increase, with nearly 50% of the population being either obese or morbidly obese. Obesity, along with...
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Changes in aquaporins expression due to acute water restriction in naturally aging mice
Aquaporins (AQPs) are water channels in the cell membrane that regulate osmosis in response to rapid changes in intracellular and extracellular fluid...
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Efficacy of progressive versus severe energy restriction on body composition and strength in concurrent trained women
PurposeThis study evaluated the concurrent training (CT) effect in combination with either progressive energy restriction (PER) or severe energy...
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Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial
BackgroundDietary sulfur amino acid restriction (SAAR) improves metabolic health in animals. In this study, we investigated the effect of dietary...
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Regulation of sexually dimorphic placental adaptation in LPS exposure-induced intrauterine growth restriction
BackgroundSexual dimorphism in placental physiology affects the functionality of placental adaptation during adverse pregnancy. Defects of placental...
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Dietary sodium restriction prevents vascular endothelial growth factor inhibitor-induced hypertension
BackgroundVascular endothelial growth factor inhibitors (VEGFIs) are effective anticancer agents which often induce hypertension. VEGFI-induced...
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Sleep restriction reduces voluntary isometric quadriceps strength through reduced neuromuscular efficiency, not impaired contractile performance
Acute sleep restriction (SR) reduces strength through an unknown mechanism. Purpose: To determine how SR affects quadriceps contractile function and...
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Effects of Calorie Restriction on Multiple Sclerosis: A Review of the Preclinical and Clinical Studies
It has been indicated that calorie restriction (CR) leads to several neuroprotective effects against physiological aging and different...
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Calorie restriction and breast cancer treatment: a mini-review
Calorie restriction (CR), referred to as a reduction in dietary calorie intake without malnutrition, has been demonstrated to be a safe way to extend...