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Proteases and Protein Kinases as Potential Drug Target
Recently, the successful pharmacological targeting of protein and phosphoinositide kinases has been applied to a wide range of diseases, most notably...
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Protein kinases: drug targets for immunological disorders
Protein kinases play a major role in cellular activation processes, including signal transduction by diverse immunoreceptors. Given their roles in...
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Paired protein kinases PRKCI-RIPK2 promote pancreatic cancer growth and metastasis via enhancing NF-κB/JNK/ERK phosphorylation
BackgroundProtein kinases play a pivotal role in the malignant evolution of pancreatic cancer (PC) through mediating phosphorylation. Many kinase...
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The disruptor of telomeric silencing 1-like (DOT1L) promotes peritoneal fibrosis through the upregulation and activation of protein tyrosine kinases
The disruptor of telomeric silencing 1-like (DOT1L), a specific histone methyltransferase that catalyzed methylation of histone H3 on lysine 79, was...
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Aging and Protein Kinases
Recently, aging has been tried to be explained with large numbers of theories, but none of them can elucidate the changes occurring in the aging...
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Bacterial Protein Kinases
Bacteria are able to inhabit and survive vastly diverse environments. This enormous adaptive capacity depend on their ability to perceive cues from...
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The Role of Protein Kinases in the Cause and Progression of Attention-Deficit Hyperactivity Disorder
Protein phosphorylation is reported to participate in numerous cellular processes like cell division, metabolism, viability, and cell death. It is...
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Insights into the structural and functional activities of forgotten Kinases: PCTAIREs CDKs
In cells, signal transduction heavily relies on the intricate regulation of protein kinases, which provide the fundamental framework for modulating...
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Protein Kinases in Hematological Disorders
Cell signaling is an important part of the complex system of molecular communication that governs basic cellular activities and coordinates cell...
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Deregulated Protein Kinases: Friend and Foe in Ischemic Stroke
Ischemic stroke is the third leading cause of mortality worldwide, but its medical management is still limited to the use of thrombolytics as a...
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Inhibition of protein kinases by proton pump inhibitors: computational screening and in vitro evaluation
Protein kinases are implicated in numerous disease conditions, and therefore, they are important therapeutic targets. In this study, Proton pump...
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Alzheimer’s Disease and Protein Kinases
Alzheimer’s disease (AD) is the most common neurodegenerative disorder and accounts for more than 60–80% of all cases of dementia. Loss of pyramidal...
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Investigating druggable kinases for targeted therapy in retinoblastoma
Retinoblastoma (RB) is a childhood retinal neoplasm and commonly treated with cytotoxic chemotherapeutic agents. However, these therapeutic...
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Beyond PI3Ks: targeting phosphoinositide kinases in disease
Lipid phosphoinositides are master regulators of almost all aspects of a cell’s life and death and are generated by the tightly regulated activity of...
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Targeting Pim kinases in hematological cancers: molecular and clinical review
Decades of research has recognized a solid role for Pim kinases in lymphoproliferative disorders. Often up-regulated following JAK/STAT and tyrosine...
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Bile Acid Toxicity and Protein Kinases
If the bile acids reach to pathological concentrations due to cholestasis, accumulation of hydrophobic bile acids within the hepatocyte may result in...
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Signal Transduction in Immune Cells and Protein Kinases
Immune response relies upon several intracellular signaling events. Among the protein kinases involved in these pathways, members of the protein...
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Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency
BackgroundThe generation of over 69 spliced HIV-1 mRNAs from one primary transcript by alternative RNA splicing emphasizes the central role that RNA...
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2-Desaza-annomontine (C81) impedes angiogenesis through reduced VEGFR2 expression derived from inhibition of CDC2-like kinases
Angiogenesis is a crucial process in the progression of various pathologies, like solid tumors, wet age-related macular degeneration, and chronic...
