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Novel high-yield potato protease inhibitor panels block a wide array of proteases involved in viral infection and crucial tissue damage
AbstractViruses critically rely on various proteases to ensure host cell entry and replication. In response to viral infection, the host will induce...
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Engineering New Protease Inhibitors Using α2-Macroglobulin
Protease inhibitors of the alpha-macroglobulin family (αM) have a unique mechanism that allows them to trap proteases that is dependent not on the...
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Serpin A12 (Vaspin) as a Serine Protease Inhibitor
Wide-ranging studies have recently been performed on adipokines and their association with metabolic processes. Vaspin, a serpin-derived adipokine,...
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Exploring the viral protease inhibitor space driven by consensus scoring-based virtual screening
Dengue fever presents a major health concern, and the lack of an effective vaccine or definite therapeutic regimen has led the research community to...
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Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma
Glioblastoma (GBM) tumors consist of multiple cell populations, including self-renewing glioblastoma stem cells (GSCs) and immunosuppressive...
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Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor
The COVID-19 pandemic spurred a broad interest in antiviral drug discovery. The SARS-CoV-2 main protease (M pro ) and papain-like protease (PL pro ) are...
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Cysteine protease inhibitor S promotes lymph node metastasis of esophageal cancer cells via VEGF-MAPK/ERK-MMP9/2 pathway
Cysteine protease inhibitor S (CST4) plays a pivotal role in the regulation of growth, invasion, and metastasis of a variety of malignancies....
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Serpin A12 (Vaspin) as a Serine Protease Inhibitor
Wide-ranging studies have recently been performed on adipokines and their association with metabolic processes. Vaspin, a serpin-derived adipokine,...
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A Computational Approach for Exploring Indinavir as a Potent Protease Inhibitor and Development of Its Microsphere for Anticancer Activity
PurposeThe objective of the present investigation was to establish a molecular association of different proteases as cancer targets with the...
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Interrogating the Impact of Protease Activity on Tumor Progression Using 3D Spheroid Models
Cancers have a complex relationship with the surrounding environment that regulates everything from progression to response to treatment. Cell–cell...
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A novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae regulates inflammasome activation through the TLR4–ROS–NLRP3 pathway
BackgroundGiant pandas ( Ailuropoda melanoleuca ) are the obligate host of the parasitic roundworm Baylisascaris schroederi . The infection of giant...
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Design, synthesis and docking study of Vortioxetine derivatives as a SARS-CoV-2 main protease inhibitor
PurposeVortioxetine an anti-depressant FDA-drug recently reported showing better in vitro efficacy against SARS-CoV-2.
MethodsIn this study, we have...
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The history, mechanism, and perspectives of nirmatrelvir (PF-07321332): an orally bioavailable main protease inhibitor used in combination with ritonavir to reduce COVID-19-related hospitalizations
The rapid development of effective vaccines to combat the SARS-CoV-2 virus has been an effective counter measure to decrease hospitalization and the...
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MALT1 Protease Regulates T-Cell Immunity via the mTOR Pathway in Oral Lichen Planus
Oral lichen planus (OLP) is a T cell–mediated immune mucosal disease of unknown pathogenesis. Whether mucosa-associated lymphoid tissue lymphoma...
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Natural Protease Inhibitors and Their Therapeutic Potentials Against SARS-CoV-2
Proteases play a key role in the pathogenesis of RNA viruses. They modify viral polypeptides by proteolytic cleavage post translation. Proteases are...
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Regulatory effects of a novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae on mice immune cells
BackgroundThe giant panda ( Ailuropoda melanoleuca ) is a well-known, rare and endangered species. Baylisascaris schroederi is a pathogenic ascarid....
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miR-126a-5p inhibits H1N1-induced inflammation and matrix protease secretion in lung fibroblasts by targeting ADAMTS-4
Upregulation of ADAMTS-4 has been reported to have an important role in lung injury, and ADAMTS-4 expression is regulated by miR-126a-5p in abdominal...
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Renal effects of the serine protease inhibitor aprotinin in healthy conscious mice
Treatment with aprotinin, a broad-spectrum serine protease inhibitor with a molecular weight of 6512 Da, was associated with acute kidney injury,...
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Crystal structures of main protease (Mpro) mutants of SARS-CoV-2 variants bound to PF-07304814
There is an urgent need to develop effective antiviral drugs to prevent the viral infection caused by constantly circulating SARS-CoV-2 as well as...
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Protease-Activated Receptors (PARs): Biology and Therapeutic Potential in Perioperative Stroke
Perioperative stroke is a devastating complication that occurs during surgery or within 30 days following the surgical procedure. Its prevalence...
