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Targeted eicosanoids profiling reveals a prostaglandin reprogramming in breast Cancer by microRNA-155
Abstract BackgroundProstaglandin is one of the key metabolites for inflammation-related carcinogenesis. Despite the microRNA-155 is implicated in...
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Profound DNA methylomic differences between single- and multi-fraction alpha irradiations of lung fibroblasts
BackgroundAlpha (α)-radiation is a ubiquitous environmental agent with epigenotoxic effects. Human exposure to α-radiation at potentially harmful...
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Role of Omics in Migraine Research and Management: A Narrative Review
Migraine is a neurological disorder defined by episodic attacks of chronic pain associated with nausea, photophobia, and phonophobia. It is known to...
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Single-nucleus RNA-seq identifies Huntington disease astrocyte states
Huntington Disease (HD) is an inherited movement disorder caused by expanded CAG repeats in the Huntingtin gene. We have used single nucleus RNASeq...
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Heterozygous Meg2 Ablation Causes Intraocular Pressure Elevation and Progressive Glaucomatous Neurodegeneration
Glaucomatous neurodegeneration represents one of the major causes of irreversible blindness worldwide. Yet, the detailed molecular mechanisms that...
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Transcriptomopathies of pre- and post-symptomatic frontotemporal dementia-like mice with TDP-43 depletion in forebrain neurons
TAR DNA-binding protein ( TDP-43) is a ubiquitously expressed nuclear protein, which participates in a number of cellular processes and has been...
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Microarray and Co-expression Network Analysis of Genes Associated with Acute Doxorubicin Cardiomyopathy in Mice
Clinical use of doxorubicin (DOX) in cancer therapy is limited by its dose-dependent cardiotoxicity. But molecular mechanisms underlying this...
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Regulatory Mutations in Human Hereditary Deafness
Moderate to profound deafness is a common sensory deficit that is estimated by the World Health Organization to affect more than 275 million people...
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Pharmacogenomics in Thrombosis
Inherited or acquired genetic abnormalities play a major role in thromboembolic complications. The goal of pharmacogenomics is to tailor medications...
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Expressed sequence tag analysis of adult human optic nerve for NEIBank: Identification of cell type and tissue markers
BackgroundThe optic nerve is a pure white matter central nervous system (CNS) tract with an isolated blood supply, and is widely used in...
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Episode-Specific Differential Gene Expression of Peripheral Blood Mononuclear Cells in Rapid Cycling Supports Novel Treatment Approaches
Molecular mechanisms underlying bipolar affective disorders are unknown. Difficulties arise from genetic and phenotypic heterogeneity of patients and...
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Gene Expression in Temporal Lobe Epilepsy is Consistent with Increased Release of Glutamate by Astrocytes
Patients with temporal lobe epilepsy (TLE) often have a shrunken hippocampus that is known to be the location in which seizures originate. The role...
