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Novel Proline Transporter Inhibitor (LQFM215) Presents Antipsychotic Effect in Ketamine Model of Schizophrenia
The glutamatergic hypothesis of schizophrenia suggests a correlation between NMDA receptor hypofunction and negative psychotic symptoms. It has been...
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Using Proline Metabolism Genes in Plant Genetic Engineering
AbstractThe literature review considers fundamental and applied aspects of plant genetic engineering related to the use of genes that control the...
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Histone H3 proline 16 hydroxylation regulates mammalian gene expression
Histone post-translational modifications (PTMs) are important for regulating various DNA-templated processes. Here, we report the existence of a...
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Targeting IGF1R signaling enhances the sensitivity of cisplatin by inhibiting proline and arginine metabolism in oesophageal squamous cell carcinoma under hypoxia
BackgroundCisplatin (DDP)-based chemotherapy is commonly adopted as the first-line treatment for patients with oesophageal squamous cell carcinoma...
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Structural and Functional Characteristics of the Proline-Rich Antimicrobial Peptide Minibactenecin from Leukocytes of Domestic Goat Capra hircus
We performed structural and functional studies of minibactenecin mini-ChBac7.5Nα, a natural proline-rich cathelicidin from domestic goat Capra hircus ....
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Mutation of the proline P81 into a serine modifies the tumour suppressor function of the von Hippel–Lindau gene in the ccRCC
BackgroundThe von Hippel–Lindau disease is an autosomal dominant syndrome associated with tumour formation in various tissues, such as retina,...
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Effect of Proline on Cell Death, Cell Cycle, and Oxidative Stress in C6 Glioma Cell Line
Since proline metabolism has been implicated to play an underlying role in apoptotic signaling and cancer, and hyperprolinemic patients present...
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Neuroprotective and Anti-inflammatory Effects of Rubiscolin-6 Analogs with Proline Surrogates in Position 2
Naturally occurring peptides, such as rubiscolins derived from spinach leaves, have been shown to possess some interesting activities. They exerted...
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Exogenous Substrates Prevent the Decline in the Cellular ATP Content of Primary Rat Astrocytes During Glucose Deprivation
Brain astrocytes are well known for their broad metabolic potential. After glucose deprivation, cultured primary astrocytes maintain a high cellular...
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Preliminary Findings on Proline-Rich Protein 14 as a Diagnostic Biomarker for Parkinson’s Disease
The nuclear envelope component proline-rich protein 14 (PRR14) is involved in the nuclear morphological alteration and activation of the mTOR...
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Clinical Evaluation of Proline, Glutamic acid, and Leucine-Rich Protein 1 Expression in Astrocytomas and Correlations with the Proliferation Marker Ki-67
Malignant astrocytomas presenting in humans of any age group are a challenge to diagnose and treat. Hence, there is a quest for new markers to...
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Role of p53 in Medulloblastoma Development
p53 is a guardian of the genome because it provides it with stability (Toufektchan and Toledo 2018). It is known as tumor suppressor gene (Surget et...
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Role of lung ornithine aminotransferase in idiopathic pulmonary fibrosis: regulation of mitochondrial ROS generation and TGF-β1 activity
Idiopathic pulmonary fibrosis (IPF) is characterized by aberrant lung remodeling and the excessive accumulation of extracellular matrix (ECM)...
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Cardioprotective Effects of Metalloproteinase Inhibitor 1-({4-[(4-Chlorobenzoyl)amino]phenyl}sulfonyl-L-Proline in Modeled Acute Myocardial Infarction
Cardioprotective effect of 1-({4 [(4 chlorobenzoyl)amino]phenyl}sulfonyl-L-proline (compound AL-828) was studied in rats with modeled acute...
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Lactobacillus paracasei L9 affects disease progression in experimental autoimmune neuritis by regulating intestinal flora structure and arginine metabolism
BackgroundAutoimmune neuropathies are common peripheral nervous system (PNS) disorders. Environmental influences and dietary components are known to...
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Integrative analysis of transcriptomic and metabolomic profiles reveals enhanced arginine metabolism in androgen-independent prostate cancer cells
BackgroundProstate cancer is a common solid tumor that affects a significant number of men worldwide. Conventional androgen deprivation therapy (ADT)...
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IRAP Analysis of Transgenic Wheat Plants with a Double-Stranded RNA Suppressor of the Proline Dehydrogenase Gene
AbstractThe polymorphism level of DNA regions flanked by inverted LTR retrotransposon repeats has been analyzed by the IRAP method in genetically...
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Virulence evaluation of Israeli Marek’s disease virus isolates from commercial poultry using their meq gene sequence
Fifty-seven Gallid alphaherpesvirus 2 (GaHV-2) isolates, collected during a 30-year period (1990–2019) from commercial poultry flocks affected by...
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Ferrous sulfate reverses cerebral metabolic abnormality induced by minimal hepatic encephalopathy
Orally administered ferrous iron was previously reported to significantly improve the cognition and locomotion of patients with minimal hepatic...
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C-terminal region of Rv1039c (PPE15) protein of Mycobacterium tuberculosis targets host mitochondria to induce macrophage apoptosis
Mycobacterium tuberculosis (Mtb) genome possesses a unique family called Proline-Glutamate/Proline-Proline-Glutamate (PE/PPE) gene family, exclusive...
