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Biomarkers of Alzheimer’s Disease Associated with Programmed Cell Death Reveal Four Repurposed Drugs
Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common cause of dementia. Programmed cell death (PCD) is mainly characterized...
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A matter of new life and cell death: programmed cell death in the mammalian ovary
BackgroundThe mammalian ovary is a unique organ that displays a distinctive feature of cyclic changes throughout the entire reproductive period. The...
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Assessing the role of programmed cell death signatures and related gene TOP2A in progression and prognostic prediction of clear cell renal cell carcinoma
Kidney Clear Cell Carcinoma (KIRC), the predominant form of kidney cancer, exhibits a diverse therapeutic response to Immune Checkpoint Inhibitors...
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A novel TCGA-validated programmed cell-death-related signature of ovarian cancer
BackgroundOvarian cancer (OC) is a gynecological malignancy tumor with high recurrence and mortality rates. Programmed cell death (PCD) is an...
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PANoptosis: a potential new target for programmed cell death in breast cancer treatment and prognosis
Breast cancer is a prevalent and severe form of cancer that affects women all over the world. The incidence and mortality of breast cancer continue...
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The landscape of programmed cell death-related lncRNAs in Alzheimer’s disease and Parkinson’s disease
This study delivers a thorough analysis of long non-coding RNAs (lncRNAs) in regulating programmed cell death (PCD), vital for neurodegenerative...
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A Machine Learning Computational Framework Develops a Multiple Programmed Cell Death Index for Improving Clinical Outcomes in Bladder Cancer
Comprehensive action patterns of programmed cell death (PCD) in bladder cancer (BLCA) have not yet been thoroughly investigated. Here, we collected...
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Exploring a specialized programmed-cell death patterns to predict the prognosis and sensitivity of immunotherapy in cutaneous melanoma via machine learning
The mortality and therapeutic failure in cutaneous melanoma (CM) are mainly caused by wide metastasis and chemotherapy resistance. Meanwhile,...
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Mitochondria-associated programmed cell death as a therapeutic target for age-related disease
Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production, support cellular activities, harbor metabolic pathways, and,...
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Ferroptosis in tumors and its relationship to other programmed cell death: role of non-coding RNAs
Programmed cell death (PCD) plays an important role in many aspects of individual development, maintenance of body homeostasis and pathological...
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The biology of YAP in programmed cell death
In the last few decades, YAP has been shown to be critical in regulating tumor progression. YAP activity can be regulated by many kinase cascade...
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Role of Pyroptosis, a Pro-inflammatory Programmed Cell Death, in Epilepsy
Epilepsy is one of the most common serious brain diseases worldwide. Programmed cell death (PCD), a cellular self-destruction phenomenon, has been...
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Nicotinic and Muscarinic Acetylcholine Receptor Agonists Counteract Cognitive Impairment in a Rat Model of Doxorubicin-Induced Chemobrain via Attenuation of Multiple Programmed Cell Death Pathways
Chemotherapy causes undesirable long-term neurological sequelae, chemotherapy-induced cognitive impairment (CICI), or chemobrain in cancer survivors....
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BMP4, SGSH, and SLC11A2 are Predicted to Be Biomarkers of Aging Associated with Programmed Cell Death
Most neurodegenerative diseases are exacerbated by aging, with symptoms often worsening over time. Programmed cell death (PCD) is a controlled cell...
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Insights into N6-methyladenosine and programmed cell death in cancer
N6-methyladenosine (m6A) methylation, the most common form of internal RNA modification in eukaryotes, has gained increasing attention and become a...
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Cell death shapes cancer immunity: spotlighting PANoptosis
PANoptosis represents a novel type of programmed cell death (PCD) with distinctive features that incorporate elements of pyroptosis, apoptosis, and...
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Association Between Diverse Cell Death Patterns Related Gene Signature and Prognosis, Drug Sensitivity, and Immune Microenvironment in Glioblastoma
Glioblastoma (GBM) is the most invasive type of glioma and is difficult to treat. Diverse programmed cell death (PCD) patterns have a significant...
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Crosstalk Between Cell Death and Spinal Cord Injury: Neurology and Therapy
Spinal cord injury (SCI) often leads to neurological dysfunction, and neuronal cell death is one of the main causes of neurological dysfunction....
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GSDMD-mediated pyroptosis dominantly promotes left ventricular remodeling and dysfunction in post-myocardial infarction: a comparison across modes of programmed cell death and mitochondrial involvement
BackgroundMyocardial infarction (MI) has recently accounted for more than one-third of global mortality. Multiple molecular pathological pathways,...
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Cell Death-NO-Today: Effect of NO and RNS on Non-apoptotic Regulated Cell Death
Nitric oxide (NO), generated either enzymatically or non-enzymatically plays a significant role in cellular physiology. At low concentration, NO acts...