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1. Enhanced Oral Bioavailability of Progesterone in Bilosome Formulation: Fabrication, Statistical Optimization, and Pharmacokinetic Study

   Progesterone, a female sex steroid hormone, is highly lipophilic, leading to poor oral bioavailability. This study aimed to develop a progesterone...

   Ronak Maheshwari, Lokesh Kumar Bhatt, Sarika Wairkar in AAPS PharmSciTech

   Article 01 February 2024
   

2. Progesterone receptor distribution in the human hypothalamus and its association with suicide

   The human hypothalamus modulates mental health by balancing interactions between hormonal fluctuations and stress responses. Stress-induced...

   Lin Zhang, Ronald W.H. Verwer, ... Dick F. Swaab in Acta Neuropathologica Communications

   Article Open access 23 January 2024
   

3. Placental progesterone and its receptor in HIV-infected pre-eclamptic women

   Given the high prevalence of HIV infection and pre-eclampsia (PE) in South Africa, this study evaluated and compared the placental immunostaining of...

   Serisha Sewnarain, Shoohana Singh, Thajasvarie Naicker in Histochemistry and Cell Biology

   Article Open access 17 November 2023
   

4. Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone

   Background

   Progesterone administration has therapeutic effects in tobacco use disorder (TUD), with females benefiting more than males. Conversion of...

   Andrew M. Novick, Korrina A. Duffy, ... C. Neill Epperson in Biology of Sex Differences

   Article Open access 23 October 2022
   

5. Addition of progesterone to feminizing gender-affirming hormone therapy in transgender individuals for breast development: a randomized controlled trial

   Background

   Feminizing gender-affirming hormone therapy (GAHT) for transgender individuals traditionally includes estradiol and androgen deprivation....

   Benthe A.M. Dijkman, Danithsia Helder, ... Koen M.A. Dreijerink in BMC Pharmacology and Toxicology

   Article Open access 20 December 2023
   

6. Modified Estrogen-Progesterone Induction Method of Mammary Gland Hyperplasia in Rats

   In female Wistar rats, mammary gland hyperplasia (MGH) was modeled according to a modified protocol involving estrogen-progesterone induction and...

   A. L. Semenov, M. L. Tyndyk, ... A. V. Panchenko in Bulletin of Experimental Biology and Medicine

   Article 01 May 2023

7. Effect of Human Cytochrome P450 2D6 Polymorphism on Progesterone Hydroxylation

   Background and Objectives

   Herein, hydroxylation activities at the 6β-position and 21-position of progesterone mediated by human cytochrome P450 (CYP)...

   Toshiro Niwa, Shoko Sasaki, ... Mayu Tanaka in European Journal of Drug Metabolism and Pharmacokinetics

   Article 15 July 2022
   

8. Progesterone Phospholipid Gel for Intramuscular Administration Prepared by In Situ-Phase Separation

   Long-term daily injection of progesterone for the treatment of threatened abortion can be a source of considerable pain to patients. To reduce the...

   Ning Dong, Lihua Tang, ... **ng Tang in AAPS PharmSciTech

   Article 03 November 2022
   

9. Progesterone modulates the DSCAM-AS1/miR-130a/ESR1 axis to suppress cell invasion and migration in breast cancer

   Background

   A preoperative-progesterone intervention increases disease-free survival in patients with breast cancer, with an unknown underlying...

   Neelima Yadav, Roma Sunder, ... Amit Dutt in Breast Cancer Research

   Article Open access 28 December 2022
   

10. Effects of Progesterone on Preclinical Animal Models of Traumatic Brain Injury: Systematic Review and Meta-analysis

    Since the publication of two phase III clinical trials not supporting the use of progesterone in patients with traumatic brain injury (TBI), several...

    Raif Gregorio Nasre-Nasser, Maria Manoela Rezende Severo, ... Bruno Dutra Arbo in Molecular Neurobiology

    Article 04 August 2022
    

11. Progesterone from ovulatory menstrual cycles is an important cause of breast cancer

    Many factors, including reproductive hormones, have been linked to a woman’s risk of develo** breast cancer (BC). We reviewed the literature...

    Herjan J. T. Coelingh Bennink, Iman J. Schultz, ... Robert D. Langer in Breast Cancer Research

    Article Open access 30 May 2023
    

12. Hemin protects against cell stress induced by estrogen and progesterone in rat mammary glands via modulation of Nrf2/HO-1 and NF-κB pathways

    Mammary gland hyperplasia is one of the risk factors for breast cancer. Till date, there is no study that has addressed the effect of hemin in this...

    Heba A. Abdel-Hamid, Heba Marey, Manar Fouli Gaber Ibrahim in Cell Stress and Chaperones

    Article 17 March 2023
    

13. Progesterone attenuates Th17-cell pathogenicity in autoimmune uveitis via Id2/Pim1 axis

    Background

    Autoimmune uveitis (AU) is the most common ophthalmic autoimmune disease (AD) and is characterized by a complex etiology, high morbidity,...

    **uxing Liu, Chenyang Gu, ... Wenru Su in Journal of Neuroinflammation

    Article Open access 21 June 2023
    

14. Endogenous oestradiol and progesterone as predictors of oncogenic human papillomavirus (HPV) persistence

    Background

    High-risk human papillomavirus (HR-HPV) is the main aetiological factor for the development of cervical cancer. While nearly 70% of HR-HPV...

    Susanne Fischer, Ulrike Kuebler, ... Ulrike Ehlert in BMC Cancer

    Article Open access 05 February 2022
    

15. Progesterone receptor antagonists reverse stem cell expansion and the paracrine effectors of progesterone action in the mouse mammary gland

    Background

    The ovarian hormones estrogen and progesterone (EP) are implicated in breast cancer causation. A specific consequence of progesterone...

    Manish Ranjan, Oukseub Lee, ... Seema A. Khan in Breast Cancer Research

    Article Open access 03 August 2021
    

16. Association of progesterone receptor status with 21-gene recurrence score and survival among patients with estrogen receptor-positive breast cancer

    Background

    Progesterone receptor (PR)-negative tumors have been shown to have worse prognosis and were underrepresented in recent trials on patients...

    Sung Jun Ma, Jasmin Gill, ... Anurag K. Singh in BMC Cancer

    Article Open access 11 April 2023
    

17. A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort

    Background

    Associations of body shape with breast cancer risk, independent of body size, are unclear because waist and hip circumferences are...

    Sofia Christakoudi, Konstantinos K. Tsilidis, ... Elio Riboli in BMC Cancer

    Article Open access 19 June 2023
    

18. Progesterone Receptor Signaling in the Breast Tumor Microenvironment

    The tumor microenvironment (TME) is a complex infrastructure composed of stromal, epithelial, and immune cells embedded in a vasculature ECM. The...

    Viroj Boonyaratanakornkit, Eileen M. McGowan, ... Richard J. Pietras in Tumor Microenvironment

    Chapter 2021
    

19. Dissolution Improvement of Progesterone and Testosterone via Impregnation on Mesoporous Silica Using Supercritical Carbon Dioxide

    Progesterone (PRG) and testosterone (TST) were impregnated on mesoporous silica (ExP) particles via supercritical carbon dioxide (scCO ₂ ) processing...

    Adejumoke Lara Ajiboye, Amélie Jacopin, ... Vivek Trivedi in AAPS PharmSciTech

    Article Open access 16 November 2022
    

20. Combined effects of progesterone and SOCS3 DNA methylation on T2DM: a case–control study

    Background

    This study aims to investigate the independent and combined effects of progesterone and suppressor of cytokine signaling ( SOCS )-3 DNA...

    Lulu Wang, Zhenxing Mao, ... Wenqian Huo in Clinical Epigenetics

    Article Open access 26 September 2021