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Harnessing large language models (LLMs) for candidate gene prioritization and selection
BackgroundFeature selection is a critical step for translating advances afforded by systems-scale molecular profiling into actionable clinical...
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Defining operational research priorities to improve malaria control and elimination in sub-Saharan Africa: results from a country-driven research prioritization setting process
BackgroundIn order to reignite gains and accelerate progress toward improved malaria control and elimination, policy, strategy, and operational...
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Prioritization of therapeutic targets for cancers using integrative multi-omics analysis
BackgroundThe integration of transcriptomic, proteomic, druggable genetic and metabolomic association studies facilitated a comprehensive...
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Prioritization of neurologic rehabilitation interventions by ELECTRE-III analysis in subacute stroke patients
BackgroundElimination and Choice Translating Reality (ELECTRE) III is a commonly used multicriteria decision-making (MCDM) method when alternatives...
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Protein–protein interaction network-based integration of GWAS and functional data for blood pressure regulation analysis
BackgroundIt is valuable to analyze the genome-wide association studies (GWAS) data for a complex disease phenotype in the context of the...
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Laundering CNV data for candidate process prioritization in brain disorders
BackgroundPrioritization of genomic data has become a useful tool for uncovering the phenotypic effect of genetic variations (e.g. copy number...
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Prioritization in visual working memory enhances memory retention and speeds up processing in a comparison task
Visual working memory retains visual information for controlling behavior. We studied how information in visual working memory is prioritized for...
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Associative gene networks reveal novel candidates important for ADHD and dyslexia comorbidity
BackgroundAttention deficit hyperactivity disorder (ADHD) is commonly associated with developmental dyslexia (DD), which are both prevalent and...
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PEDIA: prioritization of exome data by image analysis
PurposePhenotype information is crucial for the interpretation of genomic variants. So far it has only been accessible for bioinformatics workflows...
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Adverse Outcome Pathways as Versatile Tools in Liver Toxicity Testing
Adverse outcome pathways (AOPs) are tools to capture and visualize mechanisms driving toxicological effects. They share a common structure consisting...
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Artificial Intelligence for Precision Oncology
Precision oncology is an innovative approach to cancer care in which diagnosis, prognosis, and treatment are informed by the individual patient’s...
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Prioritization of genes involved in endothelial cell apoptosis by their implication in lymphedema using an analysis of associative gene networks with ANDSystem
BackgroundCurrently, more than 150 million people worldwide suffer from lymphedema. It is a chronic progressive disease characterized by high-protein...
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An AI-based approach driven by genotypes and phenotypes to uplift the diagnostic yield of genetic diseases
Identifying disease-causing variants in Rare Disease patients’ genome is a challenging problem. To accomplish this task, we describe a machine...
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Evaluation of Prioritization Methods of Extrinsic Apoptotic Signaling Pathway Genes for Retrieval of the New Candidates Associated with Major Depressive Disorder
AbstractMajor depressive disorder (MDD) is an important problem in psychophysical health and well-being of society in Russia and worldwide. In the...
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Impact of the COVID-19 pandemic on delays in diagnosis and treatment of tick-borne diseases endemic to southeastern USA
BackgroundThe Coronavirus disease 2019 (COVID-19) pandemic was marked by an increase in diagnosis and treatment delays for a range of medical...
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Computer-Assisted Interpretation of Cancer-Predisposing Variants
The increasing scope of genomic profiling in cancer care has led to a specific issue related to the interpretation of genetic variants as benign or...
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Recommendations for application of the functional evidence PS3/BS3 criterion using the ACMG/AMP sequence variant interpretation framework
BackgroundThe American College of Medical Genetics and Genomics (ACMG)/Association for Molecular Pathology (AMP) clinical variant interpretation...
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Searching for the inner self: evidence against a direct dependence of the self-prioritization effect on the ventro-medial prefrontal cortex
The processing of self-referential material is supposed to be located in the medial prefrontal cortex (MPFC) and in particular in the ventro-medial...
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Unrealized targets in the discovery of antibiotics for Gram-negative bacterial infections
Advances in areas that include genomics, systems biology, protein structure determination and artificial intelligence provide new opportunities for...
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A joint international consensus statement for measuring quality of survival for patients with childhood cancer
The aim of treating childhood cancer remains to cure all. As survival rates improve, long-term health outcomes increasingly define quality of care....
