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Identification of Regulatory Elements in Primary Sensory Neurons Involved in Trauma-Induced Neuropathic Pain
Chronic pain is a significant public health issue that is often refractory to existing therapies. Here we use a multiomic approach to identify...
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Excitatory Crossmodal Input to a Widespread Population of Primary Sensory Cortical Neurons
Crossmodal information processing in sensory cortices has been reported in sparsely distributed neurons under normal conditions and can undergo...
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C/EBPβ Participates in Nerve Trauma-Induced TLR7 Upregulation in Primary Sensory Neurons
Nerve trauma-induced toll-like receptor 7 (TLR7) expression level increases in primary sensory neurons in injured dorsal root ganglion (DRG) avails...
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Complex alterations in inflammatory pain and analgesic sensitivity in young and ageing female rats: involvement of ASIC3 and Nav1.8 in primary sensory neurons
Objective and designOur aim was to determine an age-dependent role of Nav1.8 and ASIC3 in dorsal root ganglion (DRG) neurons in a rat pre-clinical...
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A biophysically comprehensive model of urothelial afferent neurons: implications for sensory signalling in urinary bladder
The urothelium is the innermost layer of the bladder wall; it plays a pivotal role in bladder sensory transduction by responding to chemical and...
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Tissue-resident M2 macrophages directly contact primary sensory neurons in the sensory ganglia after nerve injury
BackgroundMacrophages in the peripheral nervous system are key players in the repair of nerve tissue and the development of neuropathic pain due to...
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Inhibitions and Down-Regulation of Motor Protein Eg5 Expression in Primary Sensory Neurons Reveal a Novel Therapeutic Target for Pathological Pain
The motor protein Eg5, known as kif11 or kinesin-5, interacts with adjacent microtubules in the mitotic spindle and plays essential roles in cell...
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Behaviorally relevant decision coding in primary somatosensory cortex neurons
Primary sensory cortex is thought to process incoming sensory information, while decision variables important for driving behavior are assumed to...
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Nescient helix-loop-helix 1 (Nhlh1) is a novel activating transcription factor 5 (ATF5) target gene in olfactory and vomeronasal sensory neurons in mice
Activating transcription factor 5 (ATF5) is a transcription factor that belongs to the cAMP-response element-binding protein/ATF family and is...
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Single-Unit Electrophysiological Recordings of Primary Muscle Sensory Neurons Using a Novel Ex Vivo Preparation
For decades, multiple electrophysiological techniques have been used to characterize the responses of primary afferents to a variety of stimuli under...
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The pain target NaV1.7 is expressed late during human iPS cell differentiation into sensory neurons as determined in high-resolution imaging
Human-induced pluripotent stem cells (iPS cells) are efficiently differentiated into sensory neurons. These cells express the voltage-gated sodium...
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Ascending neurons convey behavioral state to integrative sensory and action selection brain regions
Knowing one’s own behavioral state has long been theorized as critical for contextualizing dynamic sensory cues and identifying appropriate future...
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Chromatin Immunoprecipitation from Formaldehyde Cross-Linked Olfactory Sensory Neurons
Chromatin immunoprecipitation (ChIP) allows a researcher to determine the genomic occupancy of nuclear proteins, providing insight into the roles of...
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Possible Antinociceptive Mechanisms Triggered by Nanomolar Ouabain Concentrations in Primary Sensory Neurons
The responses of primary sensory neurons to subnanomolar and nanomolar ouabain concentrations, corresponding to the endogenous ouabain (EO)...
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Cancer aggravation due to persistent pain signals with the increased expression of pain-related mediators in sensory neurons of tumor-bearing mice
A growing body of evidence suggests that intractable pain reduces both the quality of life and survival in cancer patients. In the present study, we...
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A Fundamental Inequality Governing the Rate Coding Response of Sensory Neurons
A fundamental inequality governing the spike activity of peripheral neurons is derived and tested against auditory data. This inequality states that...
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Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons
BackgroundVenezuelan Equine Encephalitis virus ( VEEV) may enter the central nervous system (CNS) within olfactory sensory neurons (OSN) that...
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Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression
Sensory neurons have recently emerged as components of the tumor microenvironment. Nevertheless, whether sensory neuronal activity is important for...
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Activity-Dependent Labeling of Olfactory Sensory Neurons Using RNA Fluorescence In Situ Hybridization Followed by Phospho-S6 Immunofluorescence
This microscope-based method allows demonstrating that an odorant receptor responded to an odorant in vivo. In sections of olfactory epithelium from...
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Functional subgroups of rat and human sensory neurons: a systematic review of electrophysiological properties
Sensory neurons are responsible for the generation and transmission of nociceptive signals from the periphery to the central nervous system. They...
