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An Assessment of the Serum Activity of ADH and ALDH in Patients with Primary Biliary Cholangitis
Primary biliary cholangitis (PBC; previously known as primary biliary cirrhosis) is a chronic inflammation-induced cholestatic process in the liver....
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Microorganisms in the Pathogenesis and Management of Primary Biliary Cholangitis (with Focus on SARS-CoV-2 & Gut Microbiota)
Primary biliary cholangitis is a chronic cholestatic liver disease characterized by a selective and progressive destruction of interlobular bile...
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Multi-omics approaches for drug-response characterization in primary biliary cholangitis and autoimmune hepatitis variant syndrome
BackgroundPrimary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) variant syndrome (VS) exhibit a complex overlap of AIH features with PBC,...
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Influence of cirrhosis on outcomes of patients with advanced intrahepatic cholangiocarcinoma receiving chemotherapy
BackgroundCirrhosis is a risk factor for intrahepatic cholangiocarcinoma (iCC). However, its exact prevalence is uncertain and its impact on the...
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Microorganisms in Pathogenesis and Management of Primary Biliary Cholangitis (with Focus on Molecular Mimicry)
Primary biliary cholangitis (PBC) has been considered an enigmatic autoimmune liver disease. The immunopathogenesis of PBC has been considered a...
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A female of progressive familial intrahepatic cholestasis type 3 caused by heterozygous mutations of ABCB4 gene and her cirrhosis improved after treatment of ursodeoxycholic acid: a case report
BackgroundProgressive familial intrahepatic cholestasis (PFIC) is a group of rapidly progressive autosomal recessive disorders characterized by...
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Relationship between elevated bilirubin levels and enhanced warfarin effects during biliary obstruction
ObjectivesA marked prolongation of the prothrombin time-international normalized ratio (PT-INR) is frequently observed during biliary obstruction in...
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Primary Biliary Cholangitis
Primary biliary cholangitis (PBC), formally named primary biliary cirrhosis until 2016, is a chronic cholestatic liver disease that can potentially...
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Biomarkers of Malnutrition in Cirrhosis
Malnutrition is highly prevalent in patients with cirrhosis and is associated with increased morbidity and mortality. As a modifiable risk factor,...
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Biomarkers of Malnutrition in Cirrhosis
Malnutrition is highly prevalent in patients with cirrhosis and is associated with increased morbidity and mortality. As a modifiable risk factor,...
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The interaction between liver cirrhosis, infection by Streptococcus bovis, and colon cancer
Whether cirrhotic patients with Streptococcus bovis bacteremia have an increased risk of colorectal neoplasm is uncertain. A multicentric...
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Mesenchymal stromal cells in hepatic fibrosis/cirrhosis: from pathogenesis to treatment
Hepatic fibrosis/cirrhosis is a significant health burden worldwide, resulting in liver failure or hepatocellular carcinoma (HCC) and accounting for...
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Fenofibrate Downregulates NF-κB Signaling to Inhibit Pro-inflammatory Cytokine Secretion in Human THP-1 Macrophages and During Primary Biliary Cholangitis
Chronic liver diseases, e.g., cholestasis, are negatively impacted by inflammation, which further aggravates liver injury. Pharmacotherapy targeting...
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Spatiotemporal analysis of tumour-infiltrating immune cells in biliary carcinogenesis
BackgroundIntraductal papillary neoplasms (IPN) and biliary epithelial neoplasia (BilIN) are well‐defined precursor lesions of biliary tract...
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The Experience of Using Multipotent Mesenchymal Stromal Cells in the Treatment of Severe Recurrent Cholangitis in Children with Biliary Atresia after Kasai Surgery
This article describes the experience of application of multipotent mesenchymal stromal cells in the complex therapy of severe recurrent cholangitis...
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The intestinal and biliary microbiome in autoimmune liver disease—current evidence and concepts
Autoimmune liver diseases are a group of immune-mediated liver diseases with three distinct entities, including autoimmune hepatitis, primary biliary...
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Interleukin-33 deficiency prevents biliary injuries and repairments caused by Clonorchis sinensis via restraining type 2 cytokines
BackgroundClonorchiasis caused by Clonorchis sinensis is a zoonotic parasitic disease characterized by cholangitis, biliary proliferation, biliary...
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Loss of FOCAD, operating via the SKI messenger RNA surveillance pathway, causes a pediatric syndrome with liver cirrhosis
Cirrhosis is usually a late-onset and life-threatening disease characterized by fibrotic scarring and inflammation that disrupts liver architecture...
