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Epigenetics of prenatal stress in humans: the current research landscape
Fetal exposure to prenatal stress can have significant consequences on short- and long-term health. Epigenetic mechanisms, especially DNA methylation...
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The Effect of Prenatal Stress on the Levels of Nitric Oxide Metabolites in the CNS
Abstract —Nitric oxide has several important functions in the CNS. This neurotransmitter regulates apoptotic processes, differentiation and...
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Age and Sex Characteristics of the Blood Cytokine Profile in Rats Subjected to Prenatal Stress
Parameters of blood cytokine profile in male and female rats subjected to prenatal stress on the model of swimming in cold water (10°C, 5 min, days...
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Prenatal Stress Induces Long-Term Behavioral Sex-Dependent Changes in Rats Offspring: the Role of the HPA Axis and Epigenetics
Preclinical genetic studies have related stress early exposures with changes in gene regulatory mechanisms, including epigenetic alterations, such as...
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Exploring relationship of poor slee** habits with prenatal stress among pregnant women in Pakistan: a cross-sectional study
ObjectivePregnancy is a complex phenomenon accompanied by biological, physiological and psychosocial changes for a mother. It is also regarded as a...
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Gestational age acceleration is associated with epigenetic biomarkers of prenatal physiologic stress exposure
BackgroundPhysiological maternal stress response, such as imbalance in the glucocorticoid pathway and immune system seems to be mediated by DNA...
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Prenatal Hypoxia-Induced Adverse Reaction to Mild Stress is Associated with Depressive-Like Changes in the Glucocorticoid System of Rats
The effects of prenatal hypoxia on neurodevelopment are predominantly associated with impaired maternal glucocorticoid stimulation of the fetus,...
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Dissecting the networks underlying diverse brain disorders after prenatal glucocorticoid overexposure
New human life begins in the uterus in a period of both extreme plasticity and sensitivity to environmental disturbances. The fetal stage is also a...
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Prenatal Programming of Monocyte Chemotactic Protein-1 Signaling in Autism Susceptibility
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that involves functional and structural defects in selective central nervous...
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Prenatal Inflammatory Exposure Predisposes Offspring to Chronic Kidney Diseases Via the Activation of the eIF2α-ATF4 Pathway
It has recently become more recognized that renal diseases in adults can originate from adverse intrauterine (maternal) environmental exposures....
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Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders
The intricate relationship between immune dysregulation and neurodevelopmental disorders (NDDs) has been observed across the stages of both prenatal...
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The Effect of Prenatal Stress on Glutathione-Associated Antioxidant Enzyme Activity in Subcellular Fractions of Neocortical Neurons and Neuroglia of Rats during the Period of Intensive Myelination
Abstract —We studied the effect of prenatal stress on the activity of glutathione-associated enzymes in subcellular fractions of neurons and neuroglia...
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Effects of Prenatal Stress on Reproductive Function in Male Rats
Glucocorticoid hormones suppress testosterone production by Leydig cells, by interacting with glucocorticoid receptors located in these...
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Sex-specific differences in the mechanisms for enhanced thromboxane A2-mediated vasoconstriction in adult offspring exposed to prenatal hypoxia
BackgroundPrenatal hypoxia, a common pregnancy complication, leads to impaired cardiovascular outcomes in the adult offspring. It results in impaired...
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Maternal supplementation of alpha-lipoic acid ameliorates prenatal cytarabine-induced mutilation in reproductive development and function in F1 male adult rats
AimsCytarabine (CYT), a prevalent anticancer drug for blood cancers, detrimentally affects male reproductive development and function. Alpha-lipoic...
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Ethics of artificial intelligence in prenatal and pediatric genomic medicine
This paper examines the ethics of introducing emerging forms of artificial intelligence (AI) into prenatal and pediatric genomic medicine....
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Levels of Protein Carbonylation and Activity of Proteases in the Brain of Newborn Rats with Prenatal Hyperhomocysteinemia
Abstract — Homocysteine is a sulfur-containing amino acid formed from methionine and considered as a risk factor for a number of pathologies. An...
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Neurobiological Consequences of Early Life Stress
The foundation for the development of a broad spectrum of stress-related disorders is laid early in development. Early-life stress, including...
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The association between prenatal famine, DNA methylation and mental disorders: a systematic review and meta-analysis
BackgroundUndernutrition in pregnant women is an unfavorable environmental condition that can affect the intrauterine development via epigenetic...
